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Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring

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Book cover Health Impacts of Developmental Exposure to Environmental Chemicals

Abstract

Perfluoroalkyl substances (PFASs) are highly stable and ubiquitous compounds which have been used for more than 60 years in various products; however, their potential health effects have been assessed recently. This chapter summarizes the epidemiological studies regarding the associations of developmental exposure to PFASs with maternal and childhood health outcomes. We have focused on four main health outcomes as follows: fetal and postnatal growth, immunotoxicity, neurodevelopment, and endocrine system outcomes. Although there is a growing literature body in this field, there is still a limited number of prospective cohort studies mainly examining few PFAS types with short follow-up periods. Most studies found an association between PFASs and poor birth outcomes; however, the effects of PFASs on postnatal weight gain and obesity are not well addressed. Several studies reported immunotoxic effects of PFASs in children such as reduced vaccine response, and higher susceptibility to infectious diseases. However, the association with allergic diseases is not clear. Also, effects of PFASs on neurodevelopment are rather inconclusive. On the other hand, PFASs seem to dysregulate the endocrine system such as thyroid and steroid hormones. For the establishment of a causal relationship, further prospective cohort studies with repeated multiple compound exposure assessments are warranted.

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Acknowledgements

This research was supported in part by Grants-in-Aid for Scientific Research from the Japan Ministry of Health, Labour, and Welfare; and the Japan Agency for Medical Research and Development (AMED) under Grant Number JP18gk0110032.

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Authors and Affiliations

  1. Hokkaido University Center for Environmental and Health Sciences, Sapporo, Hokkaido, Japan

    Houman Goudarzi & Keiko Yamazaki

  2. Center for Medical Education and International Relations, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Houman Goudarzi

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  1. Houman Goudarzi
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  2. Keiko Yamazaki
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Correspondence to Houman Goudarzi .

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  1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

    Reiko Kishi

  2. Department of Environmental Health Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Philippe Grandjean

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Goudarzi, H., Yamazaki, K. (2020). Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring. In: Kishi, R., Grandjean, P. (eds) Health Impacts of Developmental Exposure to Environmental Chemicals. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-0520-1_13

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