Abstract
The family Reoviridae contains 15 genera with the genus Orbivirus being the largest of the currently classified ones. It contains Bluetongue virus (the Orbivirus type species), 27 virus species with bluetongue virus as type species and (at least) 8 currently unclassified ‘orbiviruses’. With a few exceptions, the orbiviruses infect, replicate in and are transmitted by ticks, mosquitoes, Culicoides or other blood-sucking insect vectors like phlebotomine flies. Collectively, they infect a varied vertebrate host species, including humans, domesticated and wild ruminants, felines, canines, equines, marsupials, sloths, bats and birds. Bluetongue virus (BTV), epizootic haemorrhagic disease virus (EHDV) and African horse sickness virus (AHSV) are the most economically important orbiviruses, based on their global impact on ruminant-based livestock industries (BTV and EHDV), and on horses primarily in Africa (AHSV). Complete genome sequences are currently accessible for 27 formally recognised species of Orbivirus, a complete reference database and comprehensive phylogenetic analysis for the entire genus Orbivirus, to further appreciate the taxonomic relationships, epidemiology, replication mechanisms and evolutionary process of these viruses. The phylogenetic trees show branching patterns of orbiviruses as per their vector grouping, supporting the assumption that they have evolved with their vectors through ‘co-speciation’. These analyses helped identification of novel Orbivirus species and grouped the previously unclassified viruses into existing species. The bioinformatic analyses suggest that the evolution of orbiviruses has occurred at a slower rate than other RNA arboviruses and non-vector-borne reoviruses.
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References
Abdy MJ, Howerth EE, Stallknecht DE (1999) Experimental infection of calves with epizootic hemorrhagic disease virus. Am J Vet Res 60(5):621–626
Afshar A (1994) Bluetongue: laboratory diagnosis. Comp Immunol Microbiol Infect Dis 17(3–4):221–242
Afshar A, Thomas FC, Wright PF, Shapiro JL, Shettigara PT, Anderson J (1987) Comparison of competitive and indirect enzyme-linked immunosorbent assays for detection of bluetongue virus antibodies in serum and whole blood. J Clin Microbiol 25(9):1705–1710
Afshar A, Anderson J, Nielsen KH, Pearson JE, Trotter HC, Woolhouse TR, Thevasagayam JA, Gall DE, Lapointe JM, Gustafson GA (1997) Evaluation of a competitive ELISA for detection of antibodies to epizootic hemorrhagic disease virus of deer. J Vet Diagn Invest 9(3):309–311
Aguero M, Gomez-Tejedor C, Angeles Cubillo M, Rubio C, Romero E, Jimenez-Clavero A (2008) Real-time fluorogenic reverse transcription polymerase chain reaction assay for detection of African horse sickness virus. J Vet Diagn Invest 20(3):325–328
Akita GY, Chinsangaram J, Osburn BI, Ianconescu M, Kaufman R (1992) Detection of bluetongue virus serogroup by polymerase chain reaction. J Vet Diagn Invest 4(4):400–405
Akita GY, Glenn J, Castro AE, Osburn BI (1993) Detection of bluetongue virus in clinical samples by polymerase chain reaction. J Vet Diagn Invest 5(2):154–158
Alexander KA, MacLachlan NJ, Kat PW, House C, O’Brien SJ, Lerche NW, Sawyer M, Frank LG, Holekamp K, Smale L et al (1994) Evidence of natural bluetongue virus infection among African carnivores. Am J Trop Med Hyg 51(5):568–576
Alexander KA, Kat PW, House J, House C, O’Brien SJ, Laurenson MK, McNutt JW, Osburn BI (1995) African horse sickness and African carnivores. Vet Microbiol 47(1–2):133–140
Anderson J (1984) Use of monoclonal antibody in a blocking ELISA to detect group specific antibodies to bluetongue virus. J Immunol Methods 74(1):139–149
Andrew M, Whiteley P, Janardhana V, Lobato Z, Gould A, Coupar B (1995) Antigen specificity of the ovine cytotoxic T lymphocyte response to bluetongue virus. Vet Immunol Immunopathol 47(3–4):311–322
Anthony SJ (2007) Genetic studies of epizootic haemorrhagic disease virus (EHDV). DPhil thesis submitted in partial fulfilment for the degree of Doctor of Philosophy, University of Oxford
Anthony S, Jones H, Darpel KE, Elliott H, Maan S, Samuel A, Mellor PS, Mertens PP (2007) A duplex RT-PCR assay for detection of genome segment 7 (VP7 gene) from 24 BTV serotypes. J Virol Methods 141(2):188–197
Anthony SJ, Maan N, Maan S, Sutton G, Attoui H, Mertens PP (2009a) Genetic and phylogenetic analysis of the core proteins VP1, VP3, VP4, VP6 and VP7 of epizootic haemorrhagic disease virus (EHDV). Virus Res 145(2):187–199
Anthony SJ, Maan N, Maan S, Sutton G, Attoui H, Mertens PP (2009b) Genetic and phylogenetic analysis of the non-structural proteins NS1, NS2 and NS3 of epizootic haemorrhagic disease virus (EHDV). Virus Res 145(2):211–219
Anthony SJ, Maan S, Maan N, Kgosana L, Bachanek-Bankowska K, Batten C, Darpel KE, Sutton G, Attoui H, Mertens PP (2009c) Genetic and phylogenetic analysis of the outer-coat proteins VP2 and VP5 of epizootic haemorrhagic disease virus (EHDV): comparison of genetic and serological data to characterise the EHDV serogroup. Virus Res 145(2):200–210
Anthony SJ, Darpel KE, Maan S, Sutton G, Attoui H, Mertens PP (2010) The evolution of two homologues of the core protein VP6 of epizootic haemorrhagic disease virus (EHDV), which correspond to the geographical origin of the virus. Virus Genes 40(1):67–75
Anthony SJ, Darpel KE, Belaganahalli MN, Maan N, Nomikou K, Sutton G, Attoui H, Maan S, Mertens PP (2011) RNA segment 9 exists as a duplex concatemer in an Australian strain of epizootic haemorrhagic disease virus (EHDV): genetic analysis and evidence for the presence of concatemers as a normal feature of orbivirus replication. Virology 420(2):164–171
Aradaib IE (2009) PCR detection of African horse sickness virus serogroup based on genome segment three sequence analysis. J Virol Methods 159(1):1–5
Aradaib IE, Smith WL, Osburn BI, Cullor JS (2003) A multiplex PCR for simultaneous detection and differentiation of North American serotypes of bluetongue and epizootic hemorrhagic disease viruses. Comp Immunol Microbiol Infect Dis 26(2):77–87
Aradaib IE, Mohamed ME, Abdalla TM, Sarr J, Abdalla MA, Yousof MA, Hassan YA, Karrar AR (2005) Serogrouping of United States and some African serotypes of bluetongue virus using RT-PCR. Vet Microbiol 111(3–4):145–150
Aradaib IE, Mohamed ME, Abdalla MA (2009) A single-tube RT-PCR for rapid detection and differentiation of some African isolates of palyam serogroup orbiviruses. J Virol Methods 161(1):70–74
Attoui H, Stirling JM, Munderloh UG, Billoir F, Brookes SM, Burroughs JN, de Micco P, Mertens PP, de Lamballerie X (2001) Complete sequence characterization of the genome of the St Croix River virus, a new orbivirus isolated from cells of Ixodes scapularis. J Gen Virol 82(Pt 4):795–804
Attoui H, Fang Q, Mohd Jaafar F, Cantaloube JF, Biagini P, de Micco P, de Lamballerie X (2002a) Common evolutionary origin of aquareoviruses and orthoreoviruses revealed by genome characterization of Golden shiner reovirus, Grass carp reovirus, Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family Reoviridae). J Gen Virol 83(Pt 8):1941–1951
Attoui H, Mohd Jaafar F, Biagini P, Cantaloube JF, de Micco P, Murphy FA, de Lamballerie X (2002b) Genus Coltivirus (family Reoviridae): genomic and morphologic characterization of Old World and New World viruses. Arch Virol 147(3):533–561
Attoui H, Mohd Jaafar F, Belhouchet M, Aldrovandi N, Tao S, Chen B, Liang G, Tesh RB, de Micco P, de Lamballerie X (2005a) Yunnan orbivirus, a new orbivirus species isolated from Culex tritaeniorhynchus mosquitoes in China. J Gen Virol 86(Pt 12):3409–3417
Attoui H, Mohd Jaafar F, Belhouchet M, Biagini P, Cantaloube JF, de Micco P, de Lamballerie X (2005b) Expansion of family Reoviridae to include nine-segmented dsRNA viruses: isolation and characterization of a new virus designated Aedes pseudoscutellaris reovirus assigned to a proposed genus (Dinovernavirus). Virology 343(2):212–223
Attoui H, Maan SS, Anthony SJ, Mertens PPC (2009a) Bluetongue virus, other orbiviruses and other reoviruses: their relationships and taxonomy. In: Mellor PS, Baylis M, Mertens PPC (eds) Bluetongue monograph, 1st edn. Elsevier/Academic Press, London, pp 23–552
Attoui H, Mendez-Lopez MR, Rao S, Hurtado-Alendes A, Lizaraso-Caparo F, Jaafar FM, Samuel AR, Belhouchet M, Pritchard LI, Melville L, Weir RP, Hyatt AD, Davis SS, Lunt R, Calisher CH, Tesh RB, Fujita R, Mertens PP (2009b) Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia. Virology 394(2):298–310
Attoui H, Mertens PPC, Becnel J, Belaganahalli M, Bergoin M, Brussaard CP, Chappell JD, Ciarlet M, del Vas M, Dermody TS, Dormitzer PR, Duncan R, Fcang Q, Graham R, Guglielmi KM, Harding RM, Hillman B, Maan S, Makkay A, Marzachì C, Matthijnssens J et al (2011) Reoviridae. Elsevier Academic Press, London
Backx A, Heutink R, van Rooij E, van Rijn P (2009) Transplacental and oral transmission of wild-type bluetongue virus serotype 8 in cattle after experimental infection. Vet Microbiol 138(3–4):235–243
Bansal OB, Stokes A, Bansal A, Bishop D, Roy P (1998) Membrane organization of bluetongue virus nonstructural glycoprotein NS3. J Virol 72(4):3362–3369
Barnard BJ (1997) Antibodies against some viruses of domestic animals in southern African wild animals. Onderstepoort J Vet Res 64(2):95–110
Barratt-Boyes SM, MacLachlan NJ (1995) Pathogenesis of bluetongue virus infection of cattle. J Am Vet Med Assoc 206(9):1322–1329
Barros SC, Cruz B, Luis TM, Ramos F, Fagulha T, Duarte M, Henriques M, Fevereiro M (2009) A DIVA system based on the detection of antibodies to non-structural protein 3 (NS3) of bluetongue virus. Vet Microbiol 137(3–4):252–259
Batten CA, Maan S, Shaw AE, Maan NS, Mertens PP (2008) A European field strain of bluetongue virus derived from two parental vaccine strains by genome segment reassortment. Virus Res 137(1):56–63
Batten CA, Sanders AJ, Bachanek-Bankowska K, Bin-Tarif A, Oura CA (2009) Bluetongue virus: European Community proficiency test (2007) to evaluate ELISA and RT-PCR detection methods with special reference to pooling of samples. Vet Microbiol 135(3–4):380–383
Batten CA, van Rijn PA, Oura CA (2010) Detection of the European ‘field’ strain of bluetongue virus serotype 6 by real-time RT-PCR. Vet Microbiol 141(1–2):186–188
Batten C, Darpel K, Henstock M, Fay P, Veronesi E, Gubbins S, Graves S, Frost L, Oura C (2014) Evidence for transmission of bluetongue virus serotype 26 through direct contact. PLoS One 9(5):e96049
Beaton AR, Rodriguez J, Reddy YK, Roy P (2002) The membrane trafficking protein calpactin forms a complex with bluetongue virus protein NS3 and mediates virus release. Proc Natl Acad Sci U S A 99(20):13154–13159
Belaganahalli MN (2012) Full genome sequencing and phylogenetic analyses of different Orbivirus species. PhD thesis, University of London.
Belaganahalli MN, Maan S, Maan NS, Tesh R, Attoui H, Mertens PP (2011) Umatilla virus genome sequencing and phylogenetic analysis: identification of stretch lagoon orbivirus as a new member of the Umatilla virus species. PLoS One 6(8):e23605
Belaganahalli MN, Maan S, Maan NS, Brownlie J, Tesh R, Attoui H, Mertens PP (2015) Genetic characterization of the tick-borne orbiviruses. Viruses 7(5):2185–2209
Belhouchet M, Mohd Jaafar F, Tesh R, Grimes J, Maan S, Mertens PP, Attoui H (2010) Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae). J Gen Virol 91(Pt 12):2985–2993
Belhouchet M, Mohd Jaafar F, Firth AE, Grimes JM, Mertens PP, Attoui H (2011) Detection of a fourth orbivirus non-structural protein. PLoS One 6(10):e25697
Bentley L, Fehrsen J, Jordaan F, Huismans H, du Plessis DH (2000) Identification of antigenic regions on VP2 of African horse sickness virus serotype 3 by using phage-displayed epitope libraries. J Gen Virol 81(Pt 4):993–1000
Bevan LEW (1911) The transmission of African horse sickness to the dog by feeding. Vet J 67:402–408
Bhattacharya B, Noad RJ, Roy P (2007) Interaction between Bluetongue virus outer capsid protein VP2 and vimentin is necessary for virus egress. Virol J 4:7
Billinis C, Koumbati M, Spyrou V, Nomikou K, Mangana O, Panagiotidis CA, Papadopoulos O (2001) Bluetongue virus diagnosis of clinical cases by a duplex reverse transcription-PCR: a comparison with conventional methods. J Virol Methods 98(1):77–89
Blackburn NK, Swanepoel R (1988) Observations on antibody levels associated with active and passive immunity to African horse sickness. Trop Anim Health Prod 20(4):203–210
Bonneau KR, Zhang NZ, Wilson WC, Zhu JB, Zhang FQ, Li ZH, Zhang KL, Xiao L, Xiang WB, MacLchlan NJ (2000) Phylogenetic analysis of the S7 gene does not segregate Chinese strains of bluetongue virus into a single topotype. Arch Virol 145(6):1163–1171
Bonneau KR, Mullens BA, MacLachlan NJ (2001) Occurrence of genetic drift and founder effect during quasispecies evolution of the VP2 and NS3/NS3A genes of bluetongue virus upon passage between sheep, cattle, and Culicoides sonorensis. J Virol 75(17):8298–8305
Borden EC, Murphy FA, Nathanson N, Monath TP (1971a) Effect of antilymphocyte serum on Tacaribe virus infection in infant mice. Infect Immun 3(3):466–471
Borden EC, Shope RE, Murphy FA (1971b) Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus—a new taxonomic group. Physicochemical and serological studies. J Gen Virol 13(2):261–271
Boughton CR, Hawkes RA, Naim HM (1990) Arbovirus infection in humans in NSW: seroprevalence and pathogenicity of certain Australian bunyaviruses. Aust N Z J Med 20(1):51–55
Boulanger P, Ruckerbauer GM, Bannister GL, Gray DP, Girard A (1967) Studies on bluetongue. 3. Comparison of two complement-fixation methods. Can J Comp Med Vet Sci 31(7):166–170
Bowen RA, Howard TH, Entwistle KW, Pickett BW (1983) Seminal shedding of bluetongue virus in experimentally infected mature bulls. Am J Vet Res 44(12):2268–2270
Boyce M, Wehrfritz J, Noad R, Roy P (2004) Purified recombinant bluetongue virus VP1 exhibits RNA replicase activity. J Virol 78(8):3994–4002
Boyce M, Celma CC, Roy P (2012) Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. Virol J 9:178
Boyce M, McCrae MA, Boyce P, Kim JT (2016) Inter-segment complementarity in orbiviruses: a driver for co-ordinated genome packaging in the Reoviridae? J Gen Virol 97(5):1145–1157
Bremer CW, Viljoen GJ (1998) Detection of African horse sickness virus and discrimination between two equine orbivirus serogroups by reverse transcription polymerase chain reaction. Onderstepoort J Vet Res 65(1):1–8
Brookes SM, Hyatt AD, Eaton BT (1993) Characterization of virus inclusion bodies in bluetongue virus-infected cells. J Gen Virol 74(Pt 3):525–530
Brown SE, Gonzalez HA, Bodkin DK, Tesh RB, Knudson DL (1988a) Intra- and inter-serogroup genetic relatedness of orbiviruses. II. Blot hybridization and reassortment in vitro of epizootic haemorrhagic disease serogroup, bluetongue type 10 and Pata viruses. J Gen Virol 69(Pt 1):135–147
Brown SE, Morrison HG, Buckley SM, Shope RE, Knudson DL (1988b) Genetic relatedness of the Kemerovo serogroup viruses: I. RNA-RNA blot hybridization and gene reassortment in vitro of the Kemerovo serocomplex. Acta Virol 32(5):369–378
Brown SE, Morrison HG, Karabatsos N, Knudson DL (1991) Genetic relatedness of two new Orbivirus serogroups: Orungo and Lebombo. J Gen Virol 72(Pt 5):1065–1072
Brown CC, Rhyan JC, Grubman MJ, Wilbur LA (1996) Distribution of bluetongue virus in tissues of experimentally infected pregnant dogs as determined by in situ hybridization. Vet Pathol 33(3):337–340
Burroughs JN, O’Hara RS, Smale CJ, Hamblin C, Walton A, Armstrong R, Mertens PP (1994) Purification and properties of virus particles, infectious subviral particles, cores and VP7 crystals of African horse sickness virus serotype 9. J Gen Virol 75(Pt 8):1849–1857
Butan C, Tucker P (2010) Insights into the role of the non-structural protein 2 (NS2) in Bluetongue virus morphogenesis. Virus Res 151(2):109–117
Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T (2006) Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev 19(3):531–545
Cao D, Barro M, Hoshino Y (2008) Porcine rotavirus bearing an aberrant gene stemming from an intergenic recombination of the NSP2 and NSP5 genes is defective and interfering. J Virol 82(12):6073–6077
Carpi G, Holmes EC, Kitchen A (2010) The evolutionary dynamics of bluetongue virus. J Mol Evol 70(6):583–592
Caspar DL, Klug A (1962) Physical principles in the construction of regular viruses. Cold Spring Harb Symp Quant Biol 27:1–24
Celma CC, Roy P (2009) A viral nonstructural protein regulates bluetongue virus trafficking and release. J Virol 83(13):6806–6816
Celma CC, Roy P (2011) Interaction of calpactin light chain (S100A10/p11) and a viral NS protein is essential for intracellular trafficking of nonenveloped bluetongue virus. J Virol 85(10):4783–4791
Cook S, Holmes EC (2006) A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmission. Arch Virol 151(2):309–325
Cowled C, Melville L, Weir R, Walsh S, Hyatt A, Van Driel R, Davis S, Gubala A, Boyle D (2007) Genetic and epidemiological characterization of Middle Point orbivirus, a novel virus isolated from sentinel cattle in northern Australia. J Gen Virol 88(Pt 12):3413–3422
Cowled C, Palacios G, Melville L, Weir R, Walsh S, Davis S, Gubala A, Lipkin WI, Briese T, Boyle D (2009) Genetic and epidemiological characterization of Stretch Lagoon orbivirus, a novel orbivirus isolated from Culex and Aedes mosquitoes in northern Australia. J Gen Virol 90(Pt 6):1433–1439
Cowley JA, Gorman BM (1989) Cross-neutralization of genetic reassortants of bluetongue virus serotypes 20 and 21. Vet Microbiol 19(1):37–51
Cowley JA, Gorman BM (1990) Effects of proteolytic enzymes on the infectivity, haemagglutinating activity and protein composition of bluetongue virus type 20. Vet Microbiol 22(2–3):137–152
Crafford JE, Guthrie AJ, van Vuuren M, Mertens PP, Burroughs JN, Howell PG, Hamblin C (2003) A group-specific, indirect sandwich ELISA for the detection of equine encephalosis virus antigen. J Virol Methods 112(1–2):129–135
Crafford JE, Guthrie AJ, Van Vuuren M, Mertens PP, Burroughs JN, Howell PG, Batten CA, Hamblin C (2011) A competitive ELISA for the detection of group-specific antibody to equine encephalosis virus. J Virol Methods 174(1–2):60–64
Dandawate CN (1974) Antigenic relationship among Palyam, Kasba and Vellore viruses—a new serogroup of arboviruses. Indian J Med Res 62(3):326–331
Dandawate CN, Shope RE (1975) Studies on physicochemical and biological properties of two ungrouped arboviruses: Minnal and Arkonam. Indian J Med Res 63(8):1180–1187
Dandawate CN, Rajagopalan PK, Pavri KM, Work TH (1969) Virus isolations from mosquitoes collected in North Arcot district, Madras state, and Chittoor district, Andhra Pradesh between November 1955 and October 1957. Indian J Med Res 57(8):1420–1426
Dangler CA, de Mattos CA, de Mattos CC, Osburn BI (1990) Identifying bluetongue virus ribonucleic acid sequences by the polymerase chain reaction. J Virol Methods 28(3):281–292
Darpel KE (2007) The bluetongue virus ‘ruminant host–insect vector’ transmission cycle; the role of Culicoides saliva proteins in infection. PhD thesis submitted in partial fulfilment for the degree of Doctor of Philosophy, University of London
Darpel KE, Batten CA, Veronesi E, Shaw AE, Anthony S, Bachanek-Bankowska K, Kgosana L, bin-Tarif A, Carpenter S, Muller-Doblies UU, Takamatsu HH, Mellor PS, Mertens PP, Oura CA (2007) Clinical signs and pathology shown by British sheep and cattle infected with bluetongue virus serotype 8 derived from the 2006 outbreak in northern Europe. Vet Rec 161(8):253–261
Darpel KE, Batten CA, Veronesi E, Williamson S, Anderson P, Dennison M, Clifford S, Smith C, Philips L, Bidewell C, Bachanek-Bankowska K, Sanders A, Bin-Tarif A, Wilson AJ, Gubbins S, Mertens PP, Oura CA, Mellor PS (2009) Transplacental transmission of bluetongue virus 8 in cattle, UK. Emerg Infect Dis 15(12):2025–2028
Darpel KE, Langner KF, Nimtz M, Anthony SJ, Brownlie J, Takamatsu HH, Mellor PS, Mertens PP (2011) Saliva proteins of vector Culicoides modify structure and infectivity of bluetongue virus particles. PLoS One 6(3):e17545
Davies FG, Blackburn NK (1971) The typing of bluetongue virus. Res Vet Sci 12(2):181–183
Davies FG, Otieno S (1977) Elephants and zebras as possible reservoir hosts for African horse sickness virus. Vet Rec 100(14):291–292
de Mattos CC, de Mattos CA, Osburn BI, Dangler CA, Chuang RY, Doi RH (1989) Recombinant DNA probe for serotype-specific identification of bluetongue virus 17. Am J Vet Res 50(4):536–541
de Mattos CC, de Mattos CA, MacLachlan NJ, Giavedoni LD, Yilma T, Osburn BI (1996) Phylogenetic comparison of the S3 gene of United States prototype strains of bluetongue virus with that of field isolates from California. J Virol 70(8):5735–5739
de Waal PJ, Huismans H (2005) Characterization of the nucleic acid binding activity of inner core protein VP6 of African horse sickness virus. Arch Virol 150(10):2037–2050
Della-Porta AJ (1985) Classification of orbiviruses: a need for supergroups of genera. Prog Clin Biol Res 178:267–274
Della-Porta AJ, Sellers RF, Herniman KA, Littlejohns IR, Cybinski DH, St George TD, McPhee DA, Snowdon WA, Campbell J, Cargill C, Corbould A, Chung YS, Smith VW (1983) Serological studies of Australian and Papua New Guinean cattle and Australian sheep for the presence of antibodies against bluetongue group viruses. Vet Microbiol 8(2):147–162
Della-Porta AJ, Parsonson IM, McPhee DA (1985) Problems in the interpretation of diagnostic tests due to cross-reactions between orbiviruses and broad serological responses in animals. Prog Clin Biol Res 178:445–453
DeMaula CD, Bonneau KR, MacLachlan NJ (2000) Changes in the outer capsid proteins of bluetongue virus serotype ten that abrogate neutralization by monoclonal antibodies. Virus Res 67(1):59–66
DeMaula CD, Leutenegger CM, Jutila MA, MacLachlan NJ (2002) Bluetongue virus-induced activation of primary bovine lung microvascular endothelial cells. Vet Immunol Immunopathol 86(3–4):147–157
Dilcher M, Hasib L, Lechner M, Wieseke N, Middendorf M, Marz M, Koch A, Spiegel M, Dobler G, Hufert FT, Weidmann M (2012) Genetic characterization of Tribec virus and Kemerovo virus, two tick-transmitted human-pathogenic Orbiviruses. Virology 423(1):68–76
Diprose JM, Burroughs JN, Sutton GC, Goldsmith A, Gouet P, Malby R, Overton I, Zientara S, Mertens PP, Stuart DI, Grimes JM (2001) Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core. EMBO J 20(24):7229–7239
Diprose JM, Grimes JM, Sutton GC, Burroughs JN, Meyer A, Maan S, Mertens PP, Stuart DI (2002) The core of bluetongue virus binds double-stranded RNA. J Virol 76(18):9533–9536
Doherty RL, Carley JG, Mackerras MJ, Marks EN (1963) Studies of arthropod-borne virus infections in Queensland. III. Isolation and characterization of virus strains from wild-caught mosquitoes in North Queensland. Aust J Exp Biol Med Sci 41:17–39
Doherty RL, Whitehead RH, Wetters EJ, Gorman BM, Carley JG (1970) A survey of antibody to 10 arboviruses (Koongol group, Mapputta group and ungrouped) isolated in Queensland. Trans R Soc Trop Med Hyg 64(5):748–753
Domingo E, Holland JJ (1997) RNA virus mutations and fitness for survival. Annu Rev Microbiol 51:151–178
Eaton BT, Gould AR (1987) Isolation and characterization of orbivirus genotypic variants. Virus Res 6(4):363–382
Eaton BT, Hyatt AD, White JR (1988) Localization of the nonstructural protein NS1 in bluetongue virus-infected cells and its presence in virus particles. Virology 163(2):527–537
Elbers A, Backx A, van der Spek A, Ekker M, Leijs P, Steijn K, van Langen H, van Rijn P (2008a) [Epidemiology of bluetongue virus serotype 8 outbreaks in the Netherlands in 2006]. Tijdschr Diergeneeskd 133(6):222–229
Elbers AR, Popma J, Oosterwolde S, van Rijn PA, Vellema P, van Rooij EM (2008b) A cross-sectional study to determine the seroprevalence of bluetongue virus serotype 8 in sheep and goats in 2006 and 2007 in the Netherlands. BMC Vet Res 4:33
Elbers AR, van der Spek AN, van Rijn PA (2009) Epidemiologic characteristics of bluetongue virus serotype 8 laboratory-confirmed outbreaks in The Netherlands in 2007 and a comparison with the situation in 2006. Prev Vet Med 92(1–2):1–8
Elena SF, Sanjuan R (2005) Adaptive value of high mutation rates of RNA viruses: separating causes from consequences. J Virol 79(18):11555–11558
Ellis JA, Luedke AJ, Davis WC, Wechsler SJ, Mecham JO, Pratt DL, Elliott JD (1990) T lymphocyte subset alterations following bluetongue virus infection in sheep and cattle. Vet Immunol Immunopathol 24(1):49–67
Els HJ, Verwoerd DW (1969) Morphology of bluetongue virus. Virology 38(2):213–219
Fenner F (1976) The classification and nomenclature of viruses. Summary of results of meetings of the International Committee on Taxonomy of Viruses in Madrid, September 1975. J Gen Virol 31(3):463–470
Fernandez-Pinero J, Fernandez-Pacheco P, Rodriguez B, Sotelo E, Robles A, Arias M, Sanchez-Vizcaino JM (2009) Rapid and sensitive detection of African horse sickness virus by real-time PCR. Res Vet Sci 86(2):353–358
Fields BN, Joklik WK (1969) Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus. Virology 37(3):335–342
Fields BN, Knipe DM, Howley PM (1985) Fields virology, 3rd edn. Lippincott-Raven, Philadelphia, PA
Forzan M, Wirblich C, Roy P (2004) A capsid protein of nonenveloped Bluetongue virus exhibits membrane fusion activity. Proc Natl Acad Sci U S A 101(7):2100–2105
Forzan M, Marsh M, Roy P (2007) Bluetongue virus entry into cells. J Virol 81(9):4819–4827
French TJ, Inumaru S, Roy P (1989) Expression of two related nonstructural proteins of bluetongue virus (BTV) type 10 in insect cells by a recombinant baculovirus: production of polyclonal ascitic fluid and characterization of the gene product in BTV-infected BHK cells. J Virol 63(8):3270–3278
Fu H, Leake CJ, Mertens PP, Mellor PS (1999) The barriers to bluetongue virus infection, dissemination and transmission in the vector, Culicoides variipennis (Diptera: Ceratopogonidae). Arch Virol 144(4):747–761
Gale P, Brouwer A, Ramnial V, Kelly L, Kosmider R, Fooks AR, Snary EL (2010) Assessing the impact of climate change on vector-borne viruses in the EU through the elicitation of expert opinion. Epidemiol Infect 138(2):214–225
Gambles RM (1949) Bluetongue of sheep on Cyprus. J Comp Pathol 59:176–190
Gard GP, Shorthose JE, Weir RP, Erasmus BJ (1987) The isolation of a bluetongue serotype new to Australia. Aust Vet J 64(3):87–88
Gibbs EP, Lawman MJ (1977) Infection of British deer and farm animals with epizootic haemorrhagic disease of deer virus. J Comp Pathol 87(3):335–343
Gold S, Monaghan P, Mertens P, Jackson T (2010) A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells. PLoS One 5(6):e11360
Gonzalez HA, Knudson DL (1987) Genetic relatedness of corriparta serogroup viruses. J Gen Virol 68(Pt 3):661–672
Gonzalez HA, Knudson DL (1988) Intra- and inter-serogroup genetic relatedness of orbiviruses. I. Blot hybridization of viruses of Australian serogroups. J Gen Virol 69(Pt 1):125–134
Gorman BM (1978) Susceptibility of orbiviruses to low pH and to organic solvents. Aust J Exp Biol Med Sci 56(3):359–367
Gorman BM (1979) Variation in orbiviruses. J Gen Virol 44(1):1–15
Gorman BM (1986) Evolutionary relationships among orbiviruses. Rev Sci Tech Off Int Epiz 5(2):323–332
Gorman BM, Taylor J (1978) The RNA genome of Tilligerry virus. Aust J Exp Biol Med Sci 56(3):369–371
Gorman BM, Taylor J, Walker PJ, Davidson WL, Brown F (1981) Comparison of bluetongue type 20 with certain viruses of the bluetongue and Eubenangee serological groups of orbiviruses. J Gen Virol 57(Pt 2):251–261
Gorman BM, Taylor J, Walker PJ (1983) Orbiviruses. In: Joklik WK (ed) The Reoviridae. Plenum Press, New York, pp 287–357
Goto Y, Miura Y, Kono Y (1988a) Epidemiological survey of an epidemic of congenital abnormalities with hydranencephaly-cerebellar hypoplasia syndrome of calves occurring in 1985/86 and seroepidemiological investigations on Chuzan virus, a putative causal agent of the disease, in Japan. Nippon Juigaku Zasshi 50(2):405–413
Goto Y, Miura Y, Kono Y (1988b) Serologic evidence for the etiologic role of Chuzan virus in an epizootic of congenital abnormalities with hydranencephaly-cerebellar hypoplasia syndrome of calves in Japan. Am J Vet Res 49(12):2026–2029
Gouet P, Diprose JM, Grimes JM, Malby R, Burroughs JN, Zientara S, Stuart DI, Mertens PP (1999) The highly ordered double-stranded RNA genome of bluetongue virus revealed by crystallography. Cell 97(4):481–490
Gould AR (1988) The use of recombinant DNA probes to group and type orbiviruses. A comparison of Australian and South African isolates. Arch Virol 99(3–4):205–220
Gould AR, Eaton BT (1990) The amino acid sequence of the outer coat protein VP2 of neutralizing monoclonal antibody-resistant, virulent and attenuated bluetongue viruses. Virus Res 17(3):161–172
Gould AR, Hyatt AD (1994) The orbivirus genus. Diversity, structure, replication and phylogenetic relationships. Comp Immunol Microbiol Infect Dis 17(3–4):163–188
Gould AR, Pritchard LI (1991) Phylogenetic analyses of the complete nucleotide sequence of the capsid protein (VP3) of Australian epizootic haemorrhagic disease of deer virus (serotype 2) and cognate genes from other orbiviruses. Virus Res 21(1):1–18
Gould EA, de Lamballerie X, Zanotto PM, Holmes EC (2003) Origins, evolution, and vector/host coadaptations within the genus Flavivirus. Adv Virus Res 59:277–314
Gould E, Pettersson J, Higgs S, Charrel R, de Lamballerie X (2017) Emerging arboviruses: why today? One Health 4:1–13
Grimes J, Basak AK, Roy P, Stuart D (1995) The crystal structure of bluetongue virus VP7. Nature 373(6510):167–170
Grimes JM, Burroughs JN, Gouet P, Diprose JM, Malby R, Zientara S, Mertens PP, Stuart DI (1998) The atomic structure of the bluetongue virus core. Nature 395(6701):470–478
Guirakhoo F, Catalan JA, Monath TP (1995) Adaptation of bluetongue virus in mosquito cells results in overexpression of NS3 proteins and release of virus particles. Arch Virol 140(5):967–974
Gumm ID, Newman JF (1982) The preparation of purified bluetongue virus group antigen for use as a diagnostic reagent. Arch Virol 72(1–2):83–93
Guthrie AJ, Pardini AD, Howell PG (2009) Equine encephalosis. Equine Vet Edu Manual 8:145–150
Gutsche T (1979) There was a man. Timmins, Cape Town, p 4
Hamblin C, Graham SD, Anderson EC, Crowther JR (1990) A competitive ELISA for the detection of group-specific antibodies to African horse sickness virus. Epidemiol Infect 104(2):303–312
Hamblin C, Mellor PS, Boned J (1991) The use of ELISA for the detection of African horse sickness viruses in Culicoides midges. J Virol Methods 34(2):221–225
Han Z, Harty RN (2004) The NS3 protein of bluetongue virus exhibits viroporin-like properties. J Biol Chem 279(41):43092–43097
Hanada K, Suzuki Y, Gojobori T (2004) A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes. Mol Biol Evol 21(6):1074–1080
Hassan SS, Roy P (1999) Expression and functional characterization of bluetongue virus VP2 protein: role in cell entry. J Virol 73(12):9832–9842
Hassan SH, Wirblich C, Forzan M, Roy P (2001) Expression and functional characterization of bluetongue virus VP5 protein: role in cellular permeabilization. J Virol 75(18):8356–8367
Hawkes RA, Kirkland PD, Sanders DA, Zhang F, Li Z, Davis RJ, Zhang N (2000) Laboratory and field studies of an antigen capture ELISA for bluetongue virus. J Virol Methods 85(1–2):137–149
He CQ, Ding NZ, He M, Li SN, Wang XM, He HB, Liu XF, Guo HS (2010) Intragenic recombination as a mechanism of genetic diversity in bluetongue virus. J Virol 84(21):11487–11495
Hemati B, Contreras V, Urien C, Bonneau M, Takamatsu HH, Mertens PP, Breard E, Sailleau C, Zientara S, Schwartz-Cornil I (2009) Bluetongue virus targets conventional dendritic cells in skin lymph. J Virol 83(17):8789–8799
Henning MM (1956) African horse sickness, perdesiekte, Pestis equorum. In: Animal diseases in South Africa, 3rd edn. Central News Agency, Johannesburg, pp 785–808
Hewat EA, Booth TF, Loudon PT, Roy P (1992a) Three-dimensional reconstruction of baculovirus expressed bluetongue virus core-like particles by cryo-electron microscopy. Virology 189(1):10–20
Hewat EA, Booth TF, Roy P (1992b) Structure of bluetongue virus particles by cryoelectron microscopy. J Struct Biol 109(1):61–69
Hoff GL, Trainer DO (1974) Observations on bluetongue and epizootic hemorrhagic disease viruses in white-tailed deer: (1) distribution of virus in the blood (2) cross-challenge. J Wildl Dis 10(1):25–31
Hoff GL, Griner LA, Trainer DO (1973) Bluetongue virus in exotic ruminants. J Am Vet Med Assoc 163(6):565–567
Hoffmann B, Eschbaumer M, Beer M (2009) Real-time quantitative reverse transcription-PCR assays specifically detecting bluetongue virus serotypes 1, 6, and 8. J Clin Microbiol 47(9):2992–2994
Hofmann MA, Renzullo S, Mader M, Chaignat V, Worwa G, Thuer B (2008) Genetic characterization of Toggenburg orbivirus, a new bluetongue virus, from goats, Switzerland. Emerg Infect Dis 14(12):1855–1861
Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, VandePol S (1982) Rapid evolution of RNA genomes. Science 215(4540):1577–1585
Hooper PT, Lunt RA, Gould AR, Hyatt AD, Russell GM, Kattenbelt JA, Blacksell SD, Reddacliff LA, Kirkland PD, Davis RJ, Durham PJ, Bishop AL, Waddington J (1999) Epidemic of blindness in kangaroos—evidence of a viral aetiology. Aust Vet J 77(8):529–536
Hosseini M, Hawkes RA, Kirkland PD, Dixon RJ (1998) Rapid screening of embryonated chicken eggs for bluetongue virus infection with an antigen capture enzyme linked immunosorbent assay. J Virol Methods 75(1):39–46
House C, Mikiciuk PE, Berninger ML (1990) Laboratory diagnosis of African horse sickness: comparison of serological techniques and evaluation of storage methods of samples for virus isolation. J Vet Diagn Invest 2(1):44–50
Howell PG, Kumm NA, Botha MJ (1970) The application of improved techniques to the identification of strains of bluetongue virus. Onderstepoort J Vet Res 37(1):59–66
Huismans H (1979) Protein synthesis in bluetongue virus-infected cells. Virology 92(2):385–396
Huismans H, Cloete M (1987) A comparison of different cloned bluetongue virus genome segments as probes for the detection of virus-specified RNA. Virology 158(2):373–380
Huismans H, Els HJ (1979) Characterization of the tubules associated with the replication of three different orbiviruses. Virology 92(2):397–406
Huismans H, Erasmus BJ (1981) Identification of the serotype-specific and group-specific antigens of bluetongue virus. Onderstepoort J Vet Res 48(2):51–58
Huismans H, Bremer CW, Barber TL (1979) The nucleic acid and proteins of epizootic haemorrhagic disease virus. Onderstepoort J Vet Res 46(2):95–104
Huismans H, van der Walt NT, Cloete M, Erasmus BJ (1987) Isolation of a capsid protein of bluetongue virus that induces a protective immune response in sheep. Virology 157(1):172–179
Hundley F, McIntyre M, Clark B, Beards G, Wood D, Chrystie I, Desselberger U (1987) Heterogeneity of genome rearrangements in rotaviruses isolated from a chronically infected immunodeficient child. J Virol 61(11):3365–3372
Hutcheon D (1902) Malarial catarrhal fever of sheep. Vet Rec 14:629–633
Hyatt AD, Eaton BT, Brookes SM (1989) The release of bluetongue virus from infected cells and their superinfection by progeny virus. Virology 173(1):21–34
Hyatt AD, Zhao Y, Roy P (1993) Release of bluetongue virus-like particles from insect cells is mediated by BTV nonstructural protein NS3/NS3A. Virology 193(2):592–603
Inumaru S, Roy P (1987) Production and characterization of the neutralization antigen VP2 of bluetongue virus serotype 10 using a baculovirus expression vector. Virology 157(2):472–479
Janardhana V, Andrew ME, Lobato ZI, Coupar BE (1999) The ovine cytotoxic T lymphocyte responses to bluetongue virus. Res Vet Sci 67(3):213–221
Jansen CC, Prow NA, Webb CE, Hall RA, Pyke AT, Harrower BJ, Pritchard IL, Zborowski P, Ritchie SA, Russell RC, Van Den Hurk AF (2009) Arboviruses isolated from mosquitoes collected from urban and peri-urban areas of eastern Australia. J Am Mosq Control Assoc 25(3):272–278
Jeggo MH, Wardley RC (1982) Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types. Immunology 45(4):629–635
Jeggo MH, Wardley RC (1985) Bluetongue vaccine: cells and/or antibodies. Vaccine 3(1):57–58
Jensen MJ, Wilson WC (1995) A model for the membrane topology of the NS3 protein as predicted from the sequence of segment 10 of epizootic haemorrhagic disease virus serotype 1. Arch Virol 140(4):799–805
Jimenez-Clavero MA, Aguero M, San Miguel E, Mayoral T, Lopez MC, Ruano MJ, Romero E, Monaco F, Polci A, Savini G, Gomez-Tejedor C (2006) High throughput detection of bluetongue virus by a new real-time fluorogenic reverse transcription-polymerase chain reaction: application on clinical samples from current Mediterranean outbreaks. J Vet Diagn Invest 18(1):7–17
Jochim MM, Chow TL (1969) Immunodiffusion of bluetongue virus. Am J Vet Res 30(1):33–41
Jones LD, Williams T, Bishop D, Roy P (1997) Baculovirus-expressed nonstructural protein NS2 of bluetongue virus induces a cytotoxic T-cell response in mice which affords partial protection. Clin Diagn Lab Immunol 4(3):297–301
Kar AK, Bhattacharya B, Roy P (2007) Bluetongue virus RNA binding protein NS2 is a modulator of viral replication and assembly. BMC Mol Biol 8:4
Karabatsos N (1985) International catalogue of arboviruses including certain other viruses of vertebrates, 3rd edn. American Society of Tropical Medicine and Hygiene, San Antonio, TX
Karstad L, Winter A, Trainer DO (1961) Pathology of epizootic hemorrhagic disease of deer. Am J Vet Res 22:227–235
Katz JB, Alstad AD, Gustafson GA, Moser KM (1993) Sensitive identification of bluetongue virus serogroup by a colorimetric dual oligonucleotide sorbent assay of amplified viral nucleic acid. J Clin Microbiol 31(11):3028–3030
Kirkland P (2005) Epidemic viral diseases of wildlife—sudden death in tammar wallabies, blind kangaroos, herpesviruses in pilchards-what next? Microbiol Aust 26:82–84
Koekemoer JJ, Dijk AA (2004) African horse sickness virus serotyping and identification of multiple co-infecting serotypes with a single genome segment 2 RT-PCR amplification and reverse line blot hybridization. J Virol Methods 122(1):49–56
Kusari J, Roy P (1986) Molecular and genetic comparisons of two serotypes of epizootic hemorrhagic disease of deer virus. Am J Vet Res 47(8):1713–1717
Laviada MD, Babin M, Dominguez J, Sanchez-Vizcaino JM (1992) Detection of African horse sickness virus in infected spleens by a sandwich ELISA using two monoclonal antibodies specific for VP7. J Virol Methods 38(2):229–242
Laviada MD, Roy P, Sanchez-Vizcaino JM, Casal JI (1995) The use of African horse sickness virus NS3 protein, expressed in bacteria, as a marker to differentiate infected from vaccinated horses. Virus Res 38(2–3):205–218
Libikova H, Buckley SM (1971) Serological characterization of Eurasian Kemerovo group viruses. II. Cross plaque neutralization tests. Acta Virol 15(1):79–86
Libikova H, Tesarova J, Rajcani J (1970) Experimental infection of monkeys with Kemerovo virus. Acta Virol 14(1):64–69
Libikova H, Heinz F, Ujhazyova D, Stunzner D (1978) Orbiviruses of the Kemerovo complex and neurological diseases. Med Microbiol Immunol 166(1–4):255–263
Luedke AJ, Jones RH, Walton TE (1977) Overwintering mechanism for bluetongue virus: biological recovery of latent virus from a bovine by bites of Culicoides variipennis. Am J Trop Med Hyg 26(2):313–325
Maan S (2004) Complete nucleotide sequence analysis of genome segment 2 from the twenty-four serotypes of bluetongue virus: development of nucleic acid based typing methods and molecular epidemiology. PhD thesis submitted in partial fulfilment for the degree of Doctor of Philosophy, University of London
Maan S, Maan NS, Samuel AR, Rao S, Attoui H, Mertens PP (2007) Analysis and phylogenetic comparisons of full-length VP2 genes of the 24 bluetongue virus serotypes. J Gen Virol 88(Pt 2):621–630
Maan S, Maan NS, Ross-smith N, Batten CA, Shaw AE, Anthony SJ, Samuel AR, Darpel KE, Veronesi E, Oura CA, Singh KP, Nomikou K, Potgieter AC, Attoui H, van Rooij E, van Rijn P, De Clercq K, Vandenbussche F, Zientara S, Breard E, Sailleau C, Beer M, Hoffman B, Mellor PS, Mertens PP (2008) Sequence analysis of bluetongue virus serotype 8 from the Netherlands 2006 and comparison to other European strains. Virology 377(2):308–318
Maan NS, Maan S, Nomikou K, Johnson DJ, El Harrak M, Madani H, Yadin H, Incoglu S, Yesilbag K, Allison AB, Stallknecht DE, Batten C, Anthony SJ, Mertens PP (2010a) RT-PCR assays for seven serotypes of epizootic haemorrhagic disease virus & their use to type strains from the Mediterranean region and North America. PLoS One 5(9):e12782
Maan S, Maan NS, van Rijn PA, van Gennip RG, Sanders A, Wright IM, Batten C, Hoffmann B, Eschbaumer M, Oura CA, Potgieter AC, Nomikou K, Mertens PP (2010b) Full genome characterisation of bluetongue virus serotype 6 from the Netherlands 2008 and comparison to other field and vaccine strains. PLoS One 5(4):e10323
Maan NS, Maan S, Nomikou K, Belaganahalli MN, Bachanek-Bankowska K, Mertens PP (2011a) Serotype specific primers and gel-based RT-PCR assays for ‘typing’ African horse sickness virus: identification of strains from Africa. PLoS One 6(10):e25686
Maan S, Maan NS, Nomikou K, Batten C, Antony F, Belaganahalli MN, Samy AM, Reda AA, Al-Rashid SA, El Batel M, Oura CA, Mertens PP (2011b) Novel bluetongue virus serotype from Kuwait. Emerg Infect Dis 17(5):886–889
Maan S, Maan NS, Nomikou K, Veronesi E, Bachanek-Bankowska K, Belaganahalli MN, Attoui H, Mertens PP (2011c) Complete genome characterisation of a novel 26th bluetongue virus serotype from Kuwait. PLoS One 6(10):e26147
Maan NS, Maan S, Belaganahalli MN, Ostlund EN, Johnson DJ, Nomikou K, Mertens PPC (2012) Identification and differentiation of the twenty six bluetongue virus serotypes by RT–PCR amplification of the serotype-specific genome segment 2. PLoS One 7(2):e32601
Maan S, Kumar A, Gupta AK, Dalal A, Chaudhary D, Gupta TK, Bansal N, Kumar V, Batra K, Sindhu N, Kumar A, Mahajan NK, Maan NS, Mertens PPC (2018) Concurrent infection of Bluetongue and Peste-des-petits-ruminants virus in small ruminants in Haryana State of India. Transbound Emerg Dis 65(1):235–239
MacLachlan NJ (1994) The pathogenesis and immunology of bluetongue virus infection of ruminants. Comp Immunol Microbiol Infect Dis 17(3–4):197–206
Maclachlan NJ, Guthrie AJ (2010) Re-emergence of bluetongue, African horse sickness, and other orbivirus diseases. Vet Res 41(6):35
MacLachlan NJ, Thompson J (1985) Bluetongue virus-induced interferon in cattle. Am J Vet Res 46(6):1238–1241
MacLachlan NJ, Nunamaker RA, Katz JB, Sawyer MM, Akita GY, Osburn BI, Tabachnick WJ (1994) Detection of bluetongue virus in the blood of inoculated calves: comparison of virus isolation, PCR assay, and in vitro feeding of Culicoides variipennis. Arch Virol 136:1–2), 1–8
Maclachlan NJ, Drew CP, Darpel KE, Worwa G (2009) The pathology and pathogenesis of bluetongue. J Comp Pathol 141(1):1–16
Marr JS, Malloy CD (1996) An epidemiologic analysis of the ten plagues of Egypt. Caduceus 12(1):7–24
Marshall ID, Woodroofe GM, Gard GP (1980) Arboviruses of coastal south-eastern Australia. Aust J Exp Biol Med Sci 58(1):91–102
Martin LA, Meyer AJ, O’Hara RS, Fu H, Mellor PS, Knowles NJ, Mertens PP (1998) Phylogenetic analysis of African horse sickness virus segment 10: sequence variation, virulence characteristics and cell exit. Arch Virol Suppl 14:281–293
Martinez-Torrecuadrada JL, Casal JI (1995) Identification of a linear neutralization domain in the protein VP2 of African horse sickness virus. Virology 210(2):391–399
Martinez-Torrecuadrada JL, Langeveld JP, Meloen RH, Casal JI (2001) Definition of neutralizing sites on African horse sickness virus serotype 4 VP2 at the level of peptides. J Gen Virol 82(Pt 10):2415–2424
Martins LC, Diniz JA, Silva EV, Barros VL, Monteiro HA, Azevedo RS, Quaresma JA, Vasconcelos PF (2007) Characterization of Minacu virus (Reoviridae: Orbivirus) and pathological changes in experimentally infected newborn mice. Int J Exp Pathol 88(1):63–73
McIntosh BM (1955) Horse sickness antibodies in the sera of dogs in enzootic areas. J S Afr Vet Med Assoc 26:269–272
McLaughlin BE, DeMaula CD, Wilson WC, Boyce WM, MacLachlan NJ (2003) Replication of bluetongue virus and epizootic hemorrhagic disease virus in pulmonary artery endothelial cells obtained from cattle, sheep, and deer. Am J Vet Res 64(7):860–865
Mecham JO, Dean VC (1988) Protein coding assignment for the genome of epizootic haemorrhagic disease virus. J Gen Virol 69(Pt 6):1255–1262
Mecham JO, Johnson DJ (2005) Persistence of bluetongue virus serotype 2 (BTV-2) in the southeast United States. Virus Res 113(2):116–122
Mellor PS (1994) Bluetongue. State Vet J 4:7–10
Mellor PS (2000) Replication of arboviruses in insect vectors. J Comp Pathol 123(4):231–247
Mellor PS, Boorman J (1995) The transmission and geographical spread of African horse sickness and bluetongue viruses. Ann Trop Med Parasitol 89(1):1–15
Mellor PS, Hamblin C (2004) African horse sickness. Vet Res 35(4):445–466
Mellor PS, Boorman J, Baylis M (2000) Culicoides biting midges: their role as arbovirus vectors. Annu Rev Entomol 45:307–340
Mellor P, Baylis M, Mertens P (2009) Bluetongue. Elsevier/Academic Press, London
Menzies FD, McCullough SJ, McKeown IM, Forster JL, Jess S, Batten C, Murchie AK, Gloster J, Fallows JG, Pelgrim W, Mellor PS, Oura CA (2008) Evidence for transplacental and contact transmission of bluetongue virus in cattle. Vet Rec 163(7):203–209
Mertens P (2001) Orbiviruses and Bluetongue virus. In: Encyclopedia of life sciences (ELS). John Wiley & Sons, Ltd., Chichester
Mertens P, Attoui H (2009) Orbiviruses and Bluetongue virus. In: Encyclopedia of life sciences (ELS). John Wiley & Sons, Ltd., Chichester
Mertens PP, Diprose J (2004) The bluetongue virus core: a nano-scale transcription machine. Virus Res 101(1):29–43
Mertens PP, Sangar DV (1985) Analysis of the terminal sequences of the genome segments of four orbiviruses. Virology 140(1):55–67
Mertens PP, Brown F, Sangar DV (1984) Assignment of the genome segments of bluetongue virus type 1 to the proteins which they encode. Virology 135(1):207–217
Mertens PP, Burroughs JN, Anderson J (1987) Purification and properties of virus particles, infectious subviral particles, and cores of bluetongue virus serotypes 1 and 4. Virology 157(2):375–386
Mertens PP, Pedley S, Cowley J, Burroughs JN, Corteyn AH, Jeggo MH, Jennings DM, Gorman BM (1989) Analysis of the roles of bluetongue virus outer capsid proteins VP2 and VP5 in determination of virus serotype. Virology 170(2):561–565
Mertens PP, Burroughs JN, Walton A, Wellby MP, Fu H, O’Hara RS, Brookes SM, Mellor PS (1996) Enhanced infectivity of modified bluetongue virus particles for two insect cell lines and for two Culicoides vector species. Virology 217(2):582–593
Mertens PPC, Arella M, Attoui H et al (2000) Family Reoviridae. In: van Regenmortel MHV, Fauquet CM, Bishop DHL et al (eds) Virus taxonomy. Seventh report of the international committee on taxonomy of viruses. Academic Press, New York, pp 395–480
Mertens PPC, Attoui H, Duncan R, Dermody TS (2005a) Reoviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA (eds) Virus taxonomy. Eighth report of the international committee on taxonomy of viruses. Elsevier/Academic Press, London, pp 447–560
Mertens PPC, Maan S, Samuel A, Attoui H (2005b) Orbiviruses, Reoviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA (eds) Virus taxonomy. Eighth report of the international committee on taxonomy of viruses. Elsevier/Academic Press, London, pp 466–483
Mertens PP, Maan NS, Prasad G, Samuel AR, Shaw AE, Potgieter AC, Anthony SJ, Maan S (2007) Design of primers and use of RT-PCR assays for typing European bluetongue virus isolates: differentiation of field and vaccine strains. J Gen Virol 88(Pt 10):2811–2823
Mildenberg Z, Westcott D, Bellaiche M, Dastjerdi A, Steinbach F, Drew T (2009) Equine encephalosis virus in Israel. Transbound Emerg Dis 56(8):291
Miura Y, Goto Y, Kubo M, Kono Y (1988a) Isolation of Chuzan virus, a new member of the Palyam subgroup of the genus Orbivirus, from cattle and Culicoides oxystoma in Japan. Am J Vet Res 49(12):2022–2025
Miura Y, Goto Y, Kubo M, Kono Y (1988b) Pathogenicity of Chuzan virus, a new member of the Palyam subgroup of genus Orbivirus for cattle. Nippon Juigaku Zasshi 50(3):632–637
Mohammed ME, Aradaib IE, Mukhtar MM, Ghalib HW, Riemann HP, Oyejide A, Osburn BI (1996) Application of molecular biological techniques for detection of epizootic hemorrhagic disease virus (EHDV-318) recovered from a sentinel calf in central Sudan. Vet Microbiol 52(3–4):201–208
Mohd Jaafar F, Goodwin AE, Belhouchet M, Merry G, Fang Q, Cantaloube JF, Biagini P, de Micco P, Mertens PP, Attoui H (2008) Complete characterisation of the American grass carp reovirus genome (genus Aquareovirus: family Reoviridae) reveals an evolutionary link between aquareoviruses and coltiviruses. Virology 373(2):310–321
Mohd Jaafar F, Belhouchet M, Belaganahalli M, Tesh RB, Mertens PP, Attoui H (2014) Full-genome characterisation of orungo, lebombo and changuinola viruses provides evidence for co-evolution of orbiviruses with their arthropod vectors. PLoS One 9(1):e86392
Monaco F, Polci A, Lelli R, Pinoni C, Di Mattia T, Mbulu RS, Scacchia M, Savini G (2011) A new duplex real-time RT-PCR assay for sensitive and specific detection of African horse sickness virus. Mol Cell Probes 25(2–3):87–93
Monath TP, Guirakhoo F (1996) Orbiviruses and coltiviruses. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology. Lippincott-Raven, Philadelphia, PA, pp 1735–1766
Moore DL (1974) Bluetongue and related viruses in Ibadan, Nigeria: serologic comparison of bluetongue, epizootic hemorrhagic disease of deer, and Abadina (Palyam) viral isolates. Am J Vet Res 35(8):1109–1113
Moore DL, Lee VH (1972) Antigenic relationship between the virus of epizootic haemorrhagic disease of deer and bluetongue virus. Brief report. Arch Gesamte Virusforsch 37(2):282–284
Moss SR, Ayres CM, Nuttall PA (1987) Assignment of the genome segment coding for the neutralizing epitope(s) of orbiviruses in the Great Island subgroup (Kemerovo serogroup). Virology 157(1):137–144
Moss SR, Jones LD, Nuttall PA (1992) Comparison of the major structural core proteins of tick-borne and Culicoides-borne orbiviruses. J Gen Virol 73(Pt 10):2585–2590
Moule L (1896) Histoire de la Médecine Vétérinaire. Maulde, Paris, p 38
Moulton JE (1961) Pathology of bluetongue of sheep in California. J Am Vet Med Assoc 138:493–498
Murao K, Uyeda I, Ando Y, Kimura I, Cabauatan PQ, Koganezawa H (1996) Genomic rearrangement in genome segment 12 of rice dwarf phytoreovirus. Virology 216(1):238–240
Murphy FA, Borden EC, Shope RE, Harrison A (1971) Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus—a new taxonomic group. Electron microscopic studies. J Gen Virol 13(2):273–288
Myers RM, Carey DE, Reuben R, Jesudass ES, Shope RE (1971) Vellore virus: a recently recognized agent of the Palyam group of arboviruses. Indian J Med Res 59(8):1209–1213
Nason EL, Rothagel R, Mukherjee SK, Kar AK, Forzan M, Prasad BV, Roy P (2004) Interactions between the inner and outer capsids of bluetongue virus. J Virol 78(15):8059–8067
Nevill EM (1971) Cattle and Culicoides biting midges as possible overwintering hosts of bluetongue virus. Onderstepoort J Vet Res 38(2):65–71
Nomikou K, Dovas CI, Maan S, Anthony SJ, Samuel AR, Papanastassopoulou M, Maan NS, Mangana O, Mertens PP (2009) Evolution and phylogenetic analysis of full-length VP3 genes of Eastern Mediterranean bluetongue virus isolates. PLoS One 4(7):e6437
Noon TH, Wesche SL, Cagle D, Mead DG, Bicknell EJ, Bradley GA, Riplog-Peterson S, Edsall D, Reggiardo C (2002a) Hemorrhagic disease in bighorn sheep in Arizona. J Wildl Dis 38(1):172–176
Noon TH, Wesche SL, Heffelfinger J, Fuller A, Bradley GA, Reggiardo C (2002b) Hemorrhagic disease in deer in Arizona. J Wildl Dis 38(1):177–181
O’Hara RS, Meyer AJ, Burroughs JN, Pullen L, Martin LA, Mertens PP (1998) Development of a mouse model system, coding assignments and identification of the genome segments controlling virulence of African horse sickness virus serotypes 3 and 8. Arch Virol Suppl 14:259–279
Ohashi S, Yoshida K, Yanase T, Tsuda T (2002) Analysis of intratypic variation evident in an Ibaraki virus strain and its epizootic hemorrhagic disease virus serogroup. J Clin Microbiol 40(10):3684–3688
OIE (2007) Chapter 2.2.13. Bluetongue. Terrestrial animal health code, pp 131–136. Accessed 23 Dec 2018
OIE (2008) Report reference: OIE, Ref OIE: 6964, report date: 14/04/2008, Australia. http://www.oie.int/wahis/reports/en_imm_0000006964_20080415_200102.pdf
OIE (2010a) Chapter 8.3. Bluetongue. Terrestrial animal health code
OIE (2010b) Chapter 1.2. Criteria for listing diseases. Terrestrial animal health code. Accessed 23 Dec 2018
Okamoto K, Endo Y, Inoue S, Nabeshima T, Nga PT, Guillermo PH, Yu F, Loan do P, Trang BM, Natividad FF, Hasebe F, Morita K (2010) Development of a rapid and comprehensive proteomics-based arboviruses detection system. J Virol Methods 167(1):31–36
Omori T, Inaba Y, Morimoto T, Tanaka Y, Ishitani R (1969a) Ibaraki virus, an agent of epizootic disease of cattle resembling bluetongue. I. Epidemiologic, clinical and pathologic observations and experimental transmission to calves. Jpn J Microbiol 13(2):139–157
Omori T, Inaba Y, Morimoto T, Tanaka Y, Kono M (1969b) Ibaraki virus, an agent of epizootic disease of cattle resembling bluetongue. II. Isolation of the virus in bovine cell culture. Jpn J Microbiol 13(2):159–168
Orru G, Ferrando ML, Meloni M, Liciardi M, Savini G, De Santis P (2006) Rapid detection and quantitation of Bluetongue virus (BTV) using a Molecular Beacon fluorescent probe assay. J Virol Methods 137(1):34–42
Osburn BI (1994) The impact of bluetongue virus on reproduction. Comp Immunol Microbiol Infect Dis 17(3–4):189–196
Oura C (2011) Bluetongue: new insights and lessons learnt. Vet Rec 168(14):375–376
Oura CA, El Harrak M (2011) Midge-transmitted bluetongue in domestic dogs. Epidemiol Infect 139(9):1396–1400
Owens RJ, Limn C, Roy P (2004) Role of an arbovirus nonstructural protein in cellular pathogenesis and virus release. J Virol 78(12):6649–6656
Ozkul A, Erturk A, Caliskan E, Sarac F, Ceylan C, Mertens P, Kabakli O, Dincer E, Cizmeci SG (2009) Segment 10 based molecular epidemiology of bluetongue virus (BTV) isolates from Turkey: 1999–2001. Virus Res 142(1–2):134–139
Palacios G, Cowled C, Bussetti AV, Savji N, Weir R, Wick I, Travassos da Rosa A, Calisher CH, Tesh RB, Boyle D, Lipkin WI (2011) Rapid molecular strategy for orbivirus detection and characterization. J Clin Microbiol 49(6):2314–2317
Papadopoulos O, Mellor PS, Mertens PPC (2009) Bluetongue control strategies. In: Mellor PS, Baylis M, Mertens PPC (eds) Bluetongue monograph, 1st edn. Elsevier/Academic Press, London, pp 429–452
Parker J, Herniman KA, Gibbs EP, Sellers RF (1975) An experimental inactivated vaccine against bluetongue. Vet Rec 96(13):284–287
Parkes H, Gould AR (1996) Characterisation of Wongorr virus, an Australian orbivirus. Virus Res 44(2):111–122
Parsonson IM (1990) Pathology and pathogenesis of bluetongue infections. Curr Top Microbiol Immunol 162:119–141
Patton JT, Spencer E (2000) Genome replication and packaging of segmented double-stranded RNA viruses. Virology 277(2):217–225
Pearson JE, Jochim MM (1979) Protocol for the immunodiffusion test for bluetongue. Proc Am Assoc Vet Lab Diagn 22:463
Peiris JS, Amerasinghe PH, Amerasinghe FP, Calisher CH, Perera LP, Arunagiri CK, Munasingha NB, Karunaratne SH (1994) Viruses isolated from mosquitoes collected in Sri Lanka. Am J Trop Med Hyg 51(2):154–161
Polydorou K (ed) (1985) Bluetongue in Cyprus. Alan R Liss Inc., New York
Prasad BV, Rothnagel R, Zeng CQ, Jakana J, Lawton JA, Chiu W, Estes MK (1996) Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus. Nature 382(6590):471–473
Prasad G, Minakshi, Malik YS, Maan S (1999) RT-PCR and its detection limit for cell culture grown bluetongue virus 1 using NS1 gene group specific primers. Indian J Exp Biol 37:1255–1258
Prasad G, Minakshi, Malik YS, Maan S (2000) Trends in bluetongue virus diagnostics: a review. Indian J Anim Sci 70:103–109
Prasad G, Minakshi, Malik YS (2007) Bluetongue. Publisher Indian Council of Agricultural Research, New Delhi, p 163
Pritchard LI, Gould AR, Wilson WC, Thompson L, Mertens PP, Wade-Evans AM (1995) Complete nucleotide sequence of RNA segment 3 of bluetongue virus serotype 2 (Ona-A). Phylogenetic analyses reveal the probable origin and relationship with other orbiviruses. Virus Res 35(3):247–261
Purse BV, Mellor PS, Rogers DJ, Samuel AR, Mertens PP, Baylis M (2005) Climate change and the recent emergence of bluetongue in Europe. Nat Rev Microbiol 3(2):171–181
Purse BV, Brown HE, Harrup L, Mertens PP, Rogers DJ (2008) Invasion of bluetongue and other orbivirus infections into Europe: the role of biological and climatic processes. Rev Sci Tech 27(2):427–442
Qiu W, Scholthof KB (2001) Defective interfering RNAs of a satellite virus. J Virol 75(11):5429–5432
Quan M, Lourens CW, MacLachlan NJ, Gardner IA, Guthrie AJ (2010) Development and optimisation of a duplex real-time reverse transcription quantitative PCR assay targeting the VP7 and NS2 genes of African horse sickness virus. J Virol Methods 167(1):45–52
Quist CF, Howerth EW, Bounous DI, Stallknecht DE (1997) Cell-mediated immune response and IL-2 production in white-tailed deer experimentally infected with hemorrhagic disease viruses. Vet Immunol Immunopathol 56(3–4):283–297
Rafyi A (1961) Horse sickness. Bull Off Int Epizoot 56:216–250
Ramadevi N, Roy P (1998) Bluetongue virus core protein VP4 has nucleoside triphosphate phosphohydrolase activity. J Gen Virol 79(Pt 10):2475–2480
Ramadevi N, Burroughs NJ, Mertens PP, Jones IM, Roy P (1998) Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus. Proc Natl Acad Sci U S A 95(23):13537–13542
Rao CD, Kiuchi A, Roy P (1983) Homologous terminal sequences of the genome double-stranded RNAs of bluetongue virus. J Virol 46(2):378–383
Ratinier M, Caporale M, Golder M, Franzoni G, Allan K, Nunes SF, Armezzani A, Bayoumy A, Rixon F, Shaw A, Palmarini M (2011) Identification and characterization of a novel non-structural protein of bluetongue virus. PLoS Pathog 7(12):e1002477
Ratinier M, Shaw AE, Barry G, Gu Q, Di Gialleonardo L, Janowicz A, Varela M, Randall RE, Caporale M, Palmarini M (2016) Bluetongue virus NS4 protein is an interferon antagonist and a determinant of virus virulence. J Virol 90(11):5427–5439
Reddacliff L, Kirkland P, Philbey A, Davis R, Vogelnest L, Hulst F, Blyde D, Deykin A, Smith J, Hooper P, Gould A, Hyatt A (1999) Experimental reproduction of viral chorioretinitis in kangaroos. Aust Vet J 77(8):522–528
Reinisch KM, Nibert ML, Harrison SC (2000) Structure of the reovirus core at 3.6 A resolution. Nature 404(6781):960–967
Rodriguez-Sanchez B, Fernandez-Pinero J, Sailleau C, Zientara S, Belak S, Arias M, Sanchez-Vizcaino JM (2008) Novel gel-based and real-time PCR assays for the improved detection of African horse sickness virus. J Virol Methods 151(1):87–94
Rose KA, Kirkland PD, Davies RJ, Cooper DW, Blumstein DT (2000) An epizootic of sudden death in Tammar Wallabies (Macropus eugenii). In: Proceedings of the AAZV and IAAAM joint conference, pp 166–170
Rose K, Kirkland P, Davis R, Cooper D, Blumstein D, Pritchard L, Newberry K, Lunt R (2012) Epizootics of sudden death in tammar wallabies (Macropus eugenii) associated with an orbivirus infection. Aust Vet J 90(12):505–509
Roy P (1989) Bluetongue virus genetics and genome structure. Virus Res 13(3):179–206
Roy P (1996) Orbivirus structure and assembly. Virology 216(1):1–11
Roy P (2005) Bluetongue virus proteins and particles and their role in virus entry, assembly, and release. Adv Virus Res 64:69–123
Roy P (2008) Bluetongue virus: dissection of the polymerase complex. J Gen Virol 89(Pt 8):1789–1804
Roy P, Ritter GD Jr, Akashi H, Collisson E, Inaba Y (1985) A genetic probe for identifying bluetongue virus infections in vivo and in vitro. J Gen Virol 66(Pt 7):1613–1619
Sanchez-Vizcaino JM (2004) Control and eradication of African horse sickness with vaccine. Dev Biol (Basel) 119:255–258
Sangar DV, Mertens PPC (1983) Comparison of type-1 bluetongue virus protein synthesis in vivo and in vitro. In: Compans RW, Bishop DHL (eds) Double-stranded RNA viruses. Elsevier, New York, pp 183–191
Santman-Berends IM, Hage JJ, van Rijn PA, Stegeman JA, van Schaik G (2010a) Bluetongue virus serotype 8 (BTV-8) infection reduces fertility of Dutch dairy cattle and is vertically transmitted to offspring. Theriogenology 74(8):1377–1384
Santman-Berends IM, van Wuijckhuise L, Vellema P, van Rijn PA (2010b) Vertical transmission of bluetongue virus serotype 8 virus in Dutch dairy herds in 2007. Vet Microbiol 141(1–2):31–35
Savini G, Afonso A, Mellor P, Aradaib I, Yadin H, Sanaa M, Wilson W, Monaco F, Domingo M (2011) Epizootic haemorrhagic disease. Res Vet Sci 91(1):1–17
Schwartz-Cornil I, Mertens PP, Contreras V, Hemati B, Pascale F, Breard E, Mellor PS, MacLachlan NJ, Zientara S (2008) Bluetongue virus: virology, pathogenesis and immunity. Vet Res 39(5):46
Shaw AE, Monaghan P, Alpar HO, Anthony S, Darpel KE, Batten CA, Guercio A, Alimena G, Vitale M, Bankowska K, Carpenter S, Jones H, Oura CA, King DP, Elliott H, Mellor PS, Mertens PP (2007) Development and initial evaluation of a real-time RT-PCR assay to detect bluetongue virus genome segment 1. J Virol Methods 145(2):115–126
Shaw AE, Bruning-Richardson A, Morrison EE, Bond J, Simpson J, Ross-Smith N, Alpar O, Mertens PP, Monaghan P (2013) Bluetongue virus infection induces aberrant mitosis in mammalian cells. Virol J 10:319
Shope RE, MacNamara LG, Mangold R (1955) Epizootic hemorrhagic disease of deer. N J Outdoor 6:17
Spence L, Anderson CR, Aitken TH, Downs WG (1967) Bushbush, Ieri and Lukuni viruses, three unrelated new agents isolated from Trinidadian forest mosquitoes. Proc Soc Exp Biol Med 125(1):45–50
Spreull J (1902) Report from veterinary surgeon Spreull on the result of his experiments with the malarial catarrhal fever of sheep. Agric J Cape Good Hope 20:469–477
Spreull J (1905) Malarial catarrhal fever (bluetongue) of sheep in South Africa. J Comp Pathol 18:321–337
Squire KR, Chuang RY, Chuang LC, Doi RH, Osburn BI (1985a) Molecular cloning and hybridization studies on bluetongue virus serotype 17. Prog Clin Biol Res 178:355–361
Squire KR, Chuang RY, Chuang LF, Doi RH, Osburn BI (1985b) Detecting bluetongue virus RNA in cell culture by dot hybridization with a cloned genetic probe. J Virol Methods 10(1):59–68
Stauber N, Martinez-Costas J, Sutton G, Monastyrskaya K, Roy P (1997) Bluetongue virus VP6 protein binds ATP and exhibits an RNA-dependent ATPase function and a helicase activity that catalyze the unwinding of double-stranded RNA substrates. J Virol 71(10):7220–7226
Stewart ME, Roy P (2010) Role of cellular caspases, nuclear factor-kappa B and interferon regulatory factors in Bluetongue virus infection and cell fate. Virol J 7:362
Stewart M, Hardy A, Barry G, Pinto RM, Caporale M, Melzi E, Hughes J, Taggart A, Janowicz A, Varela M, Ratinier M, Palmarini M (2015) Characterization of a second open reading frame in genome segment 10 of bluetongue virus. J Gen Virol 96(11):3280–3293
Stuart DI, Grimes JM (2006) Structural studies on orbivirus proteins and particles. Curr Top Microbiol Immunol 309:221–244
Sutton G, Grimes JM, Stuart DI, Roy P (2007) Bluetongue virus VP4 is an RNA-capping assembly line. Nat Struct Mol Biol 14(5):449–451
Swanepoel R, Blackburn NK (1976) A new member of the Palyam serogroup of orbiviruses. Vet Rec 99(18):360
Tabachnick WJ, MacLachlan NJ, Thompson LH, Hunt GJ, Patton JF (1996) Susceptibility of Culicoides variipennis sonorensis to infection by polymerase chain reaction-detectable bluetongue virus in cattle blood. Am J Trop Med Hyg 54(5):481–485
Takamatsu H, Jeggo MH (1989) Cultivation of bluetongue virus-specific ovine T cells and their cross-reactivity with different serotype viruses. Immunology 66(2):258–263
Takamatsu H, Mellor PS, Mertens PP, Kirkham PA, Burroughs JN, Parkhouse RM (2003) A possible overwintering mechanism for bluetongue virus in the absence of the insect vector. J Gen Virol 84(Pt 1):227–235
Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28(10):2731–2739
Taraporewala ZF, Chen D, Patton JT (2001) Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2. Virology 280(2):221–231
Theal GM (1899) Records of South-Eastern Africa collected in various libraries and archive departments in Europe, vol 3. Government of Cape Colony, Cape Town, p 224
Theiler A (1910) Notes on a fever in horses simulating horse-sickness. Transvaal Agric J 8:581–586
Theodoridis A, Nevill EM, Els HJ, Boshoff ST (1979) Viruses isolated from Culicoides midges in South Africa during unsuccessful attempts to isolate bovine ephemeral fever virus. Onderstepoort J Vet Res 46(4):191–198
Theron J, Huismans H, Nel LH (1996a) Identification of a short domain within the non-structural protein NS2 of epizootic haemorrhagic disease virus that is important for single strand RNA-binding activity. J Gen Virol 77(Pt 1):129–137
Theron J, Huismans H, Nel LH (1996b) Site-specific mutations in the NS2 protein of epizootic haemorrhagic disease virus markedly affect the formation of cytoplasmic inclusion bodies. Arch Virol 141(6):1143–1151
Thevasagayam JA, Mertens PP, Burroughs JN, Anderson J (1995) Competitive ELISA for the detection of antibodies against epizootic haemorrhagic disease of deer virus. J Virol Methods 55(3):417–425
Thevasagayam JA, Wellby MP, Mertens PP, Burroughs JN, Anderson J (1996) Detection and differentiation of epizootic haemorrhagic disease of deer and bluetongue viruses by serogroup-specific sandwich ELISA. J Virol Methods 56(1):49–57
Thomas CP, Booth TF, Roy P (1990) Synthesis of bluetongue virus-encoded phosphoprotein and formation of inclusion bodies by recombinant baculovirus in insect cells: it binds the single-stranded RNA species. J Gen Virol 71(Pt 9):2073–2083
Toussaint JF, Sailleau C, Breard E, Zientara S, De Clercq K (2007) Bluetongue virus detection by two real-time RT-qPCRs targeting two different genomic segments. J Virol Methods 140(1–2):115–123
Travassos da Rosa AP, Tesh RB, Pinheiro FP, Travassos da Rosa JF, Peralta PH, Knudson DL (1984) Characterization of the Changuinola serogroup viruses (Reoviridae: Orbivirus). Intervirology 21(1):38–49
Troupin C, Schnuriger A, Duponchel S, Deback C, Schnepf N, Dehee A, Garbarg-Chenon A (2011) Rotavirus rearranged genomic RNA segments are preferentially packaged into viruses despite not conferring selective growth advantage to viruses. PLoS One 6(5):e20080
Uitenweerde JM, Theron J, Stoltz MA, Huismans H (1995) The multimeric nonstructural NS2 proteins of bluetongue virus, African horse sickness virus, and epizootic hemorrhagic disease virus differ in their single-stranded RNA-binding ability. Virology 209(2):624–632
Urakawa T, Roy P (1988) Bluetongue virus tubules made in insect cells by recombinant baculoviruses: expression of the NS1 gene of bluetongue virus serotype 10. J Virol 62(11):3919–3927
Urakawa T, Ritter DG, Roy P (1989) Expression of largest RNA segment and synthesis of VP1 protein of bluetongue virus in insect cells by recombinant baculovirus: association of VP1 protein with RNA polymerase activity. Nucleic Acids Res 17(18):7395–7401
Uren MF (1986) Clinical and pathological responses of sheep and cattle to experimental infection with five different viruses of the epizootic hemorrhagic disease of deer serogroup. Aust Vet J 63(6):199–201
van Niekerk M, van Staden V, van Dijk AA, Huismans H (2001) Variation of African horse sickness virus nonstructural protein NS3 in southern Africa. J Gen Virol 82(Pt 1):149–158
van Regenmortel MH, Mahy BW (2004) Emerging issues in virus taxonomy. Emerg Infect Dis 10(1):8–13
Van Rensberg IB, De Clerk J, Groenewald HB, Botha WS (1981) An outbreak of African horse sickness in dogs. J S Afr Vet Assoc 52(4):323–325
Venter EH, Viljoen GJ, Nel LH, Huismans H, van Dijk AA (1991) A comparison of different genomic probes in the detection of virus-specified RNA in Orbivirus-infected cells. J Virol Methods 32(2–3):171–180
Verwoerd DW, Erasmus BJ (2004) Bluetongue. In: Coetzer JAW, Tustin RC (eds) Infectious diseases of livestock. Oxford University Press, Cape Town, pp 1201–1220
Verwoerd DW, Louw H, Oellermann RA (1970) Characterization of bluetongue virus ribonucleic acid. J Virol 5(1):1–7
Verwoerd DW, Els HJ, De Villiers EM, Huismans H (1972) Structure of the bluetongue virus capsid. J Virol 10(4):783–794
Verwoerd DW, Huismans H, Erasmus BJ (1979) Orbiviruses. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology. Plenum Press, New York, pp 285–345
Vieira Cde M, Nunes MR, da Silva EV, Carvalho VL, Nunes Neto JP, Cruz AC, Casseb SM, Vasconcelos HB, Quaresma JA, Vasconcelos PF (2009) Full-length sequencing and genetic characterization of Breu Branco virus (Reoviridae, Orbivirus) and two related strains isolated from Anopheles mosquitoes. J Gen Virol 90(Pt 9):2183–2190
Wade-Evans AM (1990) The complete nucleotide sequence of genome segment 7 of bluetongue virus, serotype 1 from South Africa. Nucleic Acids Res 18(16):4919
Wade-Evans AM, Mertens PP, Bostock CJ (1990) Development of the polymerase chain reaction for the detection of bluetongue virus in tissue samples. J Virol Methods 30(1):15–24
Wade-Evans AM, Mertens PP, Belsham GJ (1992) Sequence of genome segment 9 of bluetongue virus (serotype 1, South Africa) and expression analysis demonstrating that different forms of VP6 are derived from initiation of protein synthesis at two distinct sites. J Gen Virol 73(Pt 11):3023–3026
Wang LF, Crameri G (2014) Emerging zoonotic viral diseases. Rev Sci Tech 33(2):569–581
Whistler T, Swanepoel R (1988) Characterization of potentially foetotropic Palyam serogroup orbiviruses isolated in Zimbabwe. J Gen Virol 69(Pt 9):2221–2227
Whitehead RH, Doderty RL, Domrow R, Standfast HA, Wetters EJ (1968) Studies of the epidemiology of arthropod-borne virus infections at Mitchell River Mission, Cape York Peninsula, North Queensland. 3. Virus studies of wild birns, 1964–1967. Trans R Soc Trop Med Hyg 62(3):439–445
Wilson A, Carpenter S, Gloster J, Mellor P (2007) Re-emergence of bluetongue in northern Europe in 2007. Vet Rec 161(14):487–489
Wilson A, Mellor PS, Szmaragd C, Mertens PP (2009a) Adaptive strategies of African horse sickness virus to facilitate vector transmission. Vet Res 40(2):16
Wilson WC, Hindson BJ, O’Hearn ES, Hall S, Tellgren-Roth C, Torres C, Naraghi-Arani P, Mecham JO, Lenhoff RJ (2009b) A multiplex real-time reverse transcription polymerase chain reaction assay for detection and differentiation of Bluetongue virus and Epizootic hemorrhagic disease virus serogroups. J Vet Diagn Invest 21(6):760–770
Wilson WC, O’Hearn ES, Tellgren-Roth C, Stallknecht DE, Mead DG, Mecham JO (2009c) Detection of all eight serotypes of Epizootic hemorrhagic disease virus by real-time reverse transcription polymerase chain reaction. J Vet Diagn Invest 21(2):220–225
Wu X, Chen SY, Iwata H, Compans RW, Roy P (1992) Multiple glycoproteins synthesized by the smallest RNA segment (S10) of bluetongue virus. J Virol 66(12):7104–7112
Yadav PD, Albarino CG, Nyayanit DA, Guerrero L, Jenks MH, Sarkale P, Nichol ST, Mourya DT (2018) Equine encephalosis virus in India, 2008. Emerg Infect Dis 24(5):898–901
Yamakawa M, Ohashi S, Kanno T, Yamazoe R, Yoshida K, Tsuda T, Sakamoto K (2000) Genetic diversity of RNA segments 5, 7 and 9 of the Palyam serogroup orbiviruses from Japan, Australia and Zimbabwe. Virus Res 68(2):145–153
Yang DK, Hwang IJ, Kim BH, Kweon CH, Lee KW, Kang MI, Lee CS, Cho KO (2008) Serosurveillance of viral diseases in Korean native goats (Capra hircus). J Vet Med Sci 70(9):977–979
Zanotto PM, Gao GF, Gritsun T, Marin MS, Jiang WR, Venugopal K, Reid HW, Gould EA (1995) An arbovirus cline across the northern hemisphere. Virology 210(1):152–159
Zanotto PM, Gould EA, Gao GF, Harvey PH, Holmes EC (1996) Population dynamics of flaviviruses revealed by molecular phylogenies. Proc Natl Acad Sci U S A 93(2):548–553
Zientara S, Sailleau C, Moulay S, Cruciere C, el-Harrak M, Laegreid WW, Hamblin C (1998) Use of reverse transcriptase-polymerase chain reaction (RT-PCR) and dot-blot hybridisation for the detection and identification of African horse sickness virus nucleic acids. Arch Virol Suppl 14:317–327
Zientara S, Sailleau C, Dauphin G, Roquier C, Remond EM, Lebreton F, Hammoumi S, Dubois E, Agier C, Merle G, Breard E (2002) Identification of bluetongue virus serotype 2 (Corsican strain) by reverse-transcriptase PCR reaction analysis of segment 2 of the genome. Vet Rec 150(19):598–601
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Maan, S., Belaganahalli, M.N., Maan, N.S., Attoui, H., Mertens, P.P.C. (2020). Orbiviruses. In: Malik, Y., Singh, R., Yadav, M. (eds) Emerging and Transboundary Animal Viruses . Livestock Diseases and Management. Springer, Singapore. https://doi.org/10.1007/978-981-15-0402-0_8
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