Abstract
The basic aim of delivering radical radiotherapy is to deliver maximum dose to the target while sparing normal tissues as much as possible. Knowledge about the 6Rs of radiotherapy namely repair of sublethal damage in normal tissues, reoxygenation of the tumor cells, redistribution of the tumor cells into more radiosensitive phase, radiosensitivity, and remote (bystander effect) is very important in achieving this goal. The chapter describes the 6Rs of radiotherapy and its clinical significance.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cox JD, Ang KK. Radiation oncology: rationale, technique, results. 8th ed. St. Louis, MO: Mosby Elsevier; 2002.
Harrington K, Jankowska P, Hingorani M. Molecular biology for the radiation oncologist: the 5 Rs of radiobiology meet the hallmarks of cancer. Clin Oncol. 2007;19:561–71.
Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol. 2002;20:680–7.
Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, Overgaard J. Prognostic value of tumour oxygenation in 397 head and neck tumors after primary radiation therapy: an international multi-centre study. Radiother Oncol. 2005;77(1):18–24.
Suwinski R, Sowa A, Rutkowski T, Wydmanski J, Tarnawski R, Maciejewski B. Time factor in postoperative radiotherapy: a multivariate locoregional control analysis in 868 patients. Int J Radiat Oncol Biol Phys. 2003;56:399–412.
Begg A. Molecular targeting and patient individualization. In: Joiner M, van der Kogel A, editors. Basic clinical radiobiology. 4th ed. London: Hodder Arnold; 2009.
Mothersill C, Seymour CB. Review: Radiation-induced bystander effects: past history and future perspectives. Radiat Res. 2001;155:759–67.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Madan, R., Khosla, D. (2020). 6Rs of Radiation Oncology. In: Mallick, S., Rath, G., Benson, R. (eds) Practical Radiation Oncology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0073-2_28
Download citation
DOI: https://doi.org/10.1007/978-981-15-0073-2_28
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-0072-5
Online ISBN: 978-981-15-0073-2
eBook Packages: MedicineMedicine (R0)