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Clinical Significance of Cell Survival Curves

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Practical Radiation Oncology
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Abstract

Understanding cell cycles is very important in knowing radiobiology behind radiosensitivity and cell death. Cell death for non-proliferating cells is defined as the loss of specific function and for proliferating cells it is defined as the loss of reproductive integrity. This chapter will describe the basic cell survival curve and the relevant mathematical models to explain the cell survival curve (photons) at both conventional and high dose per fractions.

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References

  1. Brenner DJ, Hlatky LR, Hahnfeldt PJ, Hall EJ, Sachs RK. A convenient extension of the linear-quadratic model to include redistribution and reoxygenation. Int J Radiat Oncol Biol Phys. 1995;32(2):379–90.

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Giridhar, P., Rath, G.K. (2020). Clinical Significance of Cell Survival Curves. In: Mallick, S., Rath, G., Benson, R. (eds) Practical Radiation Oncology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0073-2_27

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  • DOI: https://doi.org/10.1007/978-981-15-0073-2_27

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-0072-5

  • Online ISBN: 978-981-15-0073-2

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