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Advance Class of Antibiotics of the Twenty-First Century

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Antibiotic Resistant Bacteria: A Challenge to Modern Medicine
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Abstract

Microbes are the dominating organism on earth; they have impacted the life of animals as well as on humans during the course of evolution. Humans have encounter with plethora of microbes in several ways. Consequently, microbes get familiarized themselves with a new host (human) and further shared their residence with the most complex and intelligent organism on earth. The desire of humans for a civilized life them on a battlefield. Herein, the complex and brainy organisms were defeated by tiny creatures many times. During this phase microbes acquired several traits which helped them in conquering the battle with humans, and adversely affacted thier life. After the incorporation of techniques, micrbial world could explored. Sophisticated instruments have revealed fine aspects of microbes and get familiarized that they as bad as good. There are sever epidemic and pandemics have been reported those threateded the humanity.  Ancient medical history is an evidence of deadly pathogens and failure of controlling strategies. However, the modern era of antibiotic brought some hope for disease-free civilized life on this planet. In this chapter, the details of twenty-first-century antibiotics have been discussed.

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References

  • Abraham EP, Chain E (1940) An enzyme from bacteria able to destroy penicillin. Nature 146(3713):837

    Article  CAS  Google Scholar 

  • Burnet M, Burnet FM, White DO (1972) Natural history of infectious disease. CUP Archive

    Google Scholar 

  • Cullinan M, Clarke M, Dallman T, Peart S, Wilson D, Weiand D (2017) Salmonella Typhimurium gastroenteritis leading to chronic prosthetic vascular graft infection. JMM Case Rep 4(8):e005104

    Article  Google Scholar 

  • Dawson R, Harris K, Conradie A, Burger D, Murray S, Mendel C, Spigelman M (2017) Efficacy of bedaquiline, pretomanid, moxifloxacin & PZA (BPAMZ) against DS-& MDR-TB. In: Conference on retroviruses and opportunistic infections [proceedings on the internet], pp 13–16

    Google Scholar 

  • Donadio S, Maffioli S, Monciardini P, Sosio M, Jabes D (2010) Antibiotic discovery in the twenty-first century: current trends and future perspectives. J Antibiot 63(8):423

    Article  CAS  Google Scholar 

  • Eckburg P (2009) Focus 1 and 2: randomized double-blinded, multicenter phase III trials of the efficacy and safety of ceftaroline (CPT) vs ceftriaxone (CRO) in community-acquired pneumonia (CAP). In: Abstracts of papers of 49th Intersci Conf on Antimicrob Agents Chemother, San Francisco, 2009

    Google Scholar 

  • European Centre for Disease Prevention and Control (2008) Annual epidemiological report on communicable diseases, 2008. European Centre for Disease Prevention of Control, Stockholm

    Google Scholar 

  • FDA, DRAFT GUIDANCE (2017 January) Medical product communications that are consistent with the Food and Drug Administration-required Labeling—questions and answers, https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm537130.pdf

  • Fernandes P, Martens E, Bertrand D, Pereira D (2016) The solithromycin journey—it is all in the chemistry. Bioorg Med Chem. https://doi.org/10.1016/j.bmc.2016.08.035

    Article  CAS  Google Scholar 

  • Garcia-Salguero C, Rodriguez-Avial I, Picazo JJ, Culebras E (2015) Can plazomicin alone or in combination be a therapeutic option against carbapenem-resistant Acinetobacter baumannii? Antimicrob Agents Chemother 59(10). (2015)):5959–5966

    Article  CAS  Google Scholar 

  • Gibbons RJ (1964) The source of salivary bacteria. Arch Oral Biol 9:101–103

    Article  CAS  Google Scholar 

  • Gonzalez-Escobedo G, Marshall JM, Gunn JS (2011) Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state. Nat Rev Microbiol 9(1):9

    Article  CAS  Google Scholar 

  • Gottlieb S, Food, U.S (2018) Statement from FDA Commissioner Scott Gottlieb. In: MD on new steps to improve FDA review of shared risk evaluation and mitigation strategies to improve generic drug access. US Food and Drug Administration. [Online]. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm584259.htm. p 14

  • Hunter PR (2003) Climate change and waterborne and vector-borne disease. J Appl Microbiol 94:37–46

    Article  Google Scholar 

  • Kepplinger EE (2015) FDA’s expedited approval mechanisms for new drug products. Biotechnol Law Rep 34(1):15–37

    Article  Google Scholar 

  • Kirby WM (1944) Extraction of a highly potent penicillin inactivator from penicillin resistant staphylococci. Science 99(2579):452–453

    Article  CAS  Google Scholar 

  • Lapuebla A, Abdallah M, Olafisoye O, Cortes C, Urban C, Landman D, Quale J (2015) Activity of imipenem with relebactam against gram-negative pathogens from New York City. Antimicrob Agents Chemother 59(8):5029–5031. https://doi.org/10.1128/AAC.00830-15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Low M (2017) The tuberculosis treatment pipeline: a breakthrough year for the treatment of XDR-TB. PIPELINE REPORT. p 129

    Google Scholar 

  • Mack A, Choffnes ER, Hamburg MA, Relman DA (eds) (2009) Microbial evolution and co-adaptation: a tribute to the life and scientific legacies of Joshua Lederberg: workshop summary. National Academies Press

    Google Scholar 

  • Nelson K et al (2017) Whole-genome sequencing and spatial analysis of XDR-TB transmission in South Africa. Conference on Retroviruses and Opportunistic Infections (CROI 2017), Seattle, abstract 77

    Google Scholar 

  • Noel GJ, Bush K, Bagchi P, Ianus J, Strauss RS (2008) A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin Infect Dis 46(5):647–655

    Article  Google Scholar 

  • O’Gara JP (2017) Into the storm: chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life-threatening infections. Environ Microbiol 19(10):3823–3833

    Article  Google Scholar 

  • Patz JA, Graczyk TK, Geller N, Vittor AY (2000) Effects of environmental change on emerging parasitic diseases. Int J Parasitol 30(12–13):1395–1405

    Article  CAS  Google Scholar 

  • Ryan F (1992) The forgotten plague: how the battle against tuberculosis was won – and lost. Little, Brown, p 323

    Google Scholar 

  • Saxton K, Baines SD, Freeman J, O’Connor R, Wilcox MH (2009) Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model. Antimicrob Agents Chemother 53(2):412–420

    Article  CAS  Google Scholar 

  • Sparling PF (1983a) Bacterial virulence and pathogenesis: an overview. Rev Infect Dis 5(Suppl 4):S637–S646

    Article  Google Scholar 

  • Sparling GP (1983b) Estimation of microbial biomass and activity in soil using microcalorimetry. J Soil Sci 34(2):381–390

    Article  CAS  Google Scholar 

  • Surber J (2009) Efficacy and safety of torezolid phosphate (torezolid) in a dose-ranging phase 2 randomized, double-blind study in patients with severe complicated skin and skin structure infections (cSSSI). In: Abstracts of papers of 49th Interscience Conference on Antimicrob Agents Chemother, San Francisco, 2009

    Google Scholar 

  • Tenover FC, McGowan JE Jr (1996) Reasons for the emergence of antibiotic resistance. Am J Med Sci 311(1):9–16

    Article  CAS  Google Scholar 

  • Tiberi S, Payen MC, Manika K, Ladeira I, Gonzalez Sanz M, Muñoz-Torrico M et al (2018) Clinical cases. In: Migliori GB, Bothamley G, Duarte R (eds) Tuberculosis (ERS monograph). European Respiratory Society, Sheffield, pp 381–398

    Google Scholar 

  • Wilson ME (1995) Travel and the emergence of infectious diseases. Emerg Infect Dis 1(2):39

    Article  CAS  Google Scholar 

  • Ylikoski J, Savolainen S, Jousimies-Somer H (1989) Bacterial flora in the nasopharynx and nasal cavity of healthy young men. ORL 51(1):50–55

    Article  CAS  Google Scholar 

  • Zhanel GG, Cheung D, Adam H, Zelenitsky S, Golden A, Schweizer F, Gorityala B, Lagace-Wiens PR, Walkty A, Gin AS, Hoban DJ, Karlowsky JA (2016) Review of eravacycline, a novel fluorocycline antibacterial agent. Drugs 76(5):567–588

    Article  CAS  Google Scholar 

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Sagar, S., Kaistha, S., Das, A.J., Kumar, R. (2019). Advance Class of Antibiotics of the Twenty-First Century. In: Antibiotic Resistant Bacteria: A Challenge to Modern Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-9879-7_3

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