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Biological and Bio-inspired Nanomaterials pp 35–60Cite as

Peptide Self-Assembly and Its Modulation: Imaging on the Nanoscale

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1174))

Abstract

This chapter intends to review the progress in obtaining site-specific structural information for peptide assemblies using scanning tunneling microscopy. The effects on assembly propensity due to mutations and modifications in peptide sequences, small organic molecules and conformational transitions of peptides are identified. The obtained structural insights into the sequence-dependent assembly propensity could inspire rational design of peptide architectures at the molecular level.

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Abbreviations

4Bpy:

4,4′-bipyridyl

AD:

Alzheimer’s disease

AFM:

Atomic force microscopy

ALS:

Amyotrophic lateral sclerosis

Aβ:

Beta-amyloid peptides

CD:

Circular dichroism

DPE:

1,2-di(4-pyridyl)-ethylene

FTIR:

Fourier transform infrared spectroscopy

FTLD:

Frontotemporal lobar degeneration

hIAPP:

Human islet amyloid polypeptide

HOPG:

Highly oriented pyrolytic graphite

MD:

Molecular dynamics

NMR:

Nuclear magnetic resonance

PcCu(SO3Na)4 :

Copper phthalocyanine tetrasulfonate sodium

STM:

Scanning tunneling microscopy

TDP-43:

TAR DNA-binding protein 43

TEM:

Transmission electron microscopy

ThT:

Thioflavin T

TSE:

Transmissible spongiform encephalopathy

UHV:

Ultrahigh vacuum

VNTRs:

Variable number of tandem repeats

XRD:

X-ray diffraction

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Acknowledgement

This work was supported by the National Natural Science Foundation of China (91127043, 21332006, 21273051) and the National Basic Research Program of China (2013CB934200) and the Chinese Academy of Sciences (XDA09030306, YZ201317). Financial support from the CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety and the Key Laboratory of Standardization and Measurement for Nanotechnology are also gratefully acknowledged.

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Authors and Affiliations

  1. National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, China

    Lanlan Yu, Yanlian Yang & Chen Wang

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  1. Lanlan Yu
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  2. Yanlian Yang
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  3. Chen Wang
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Correspondence to Chen Wang .

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  1. National Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences, Beijing, China

    Sarah Perrett

  2. Department of Biotechnology and Biomedicine, Technical University of Denmark DTU, Lyngby, Denmark

    Alexander K. Buell

  3. Department of Chemistry, University of Cambridge, Cambridge, UK

    Tuomas P.J. Knowles

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Yu, L., Yang, Y., Wang, C. (2019). Peptide Self-Assembly and Its Modulation: Imaging on the Nanoscale. In: Perrett, S., Buell, A., Knowles, T. (eds) Biological and Bio-inspired Nanomaterials. Advances in Experimental Medicine and Biology, vol 1174. Springer, Singapore. https://doi.org/10.1007/978-981-13-9791-2_2

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