Abstract
The development of coherent multidimensional microspectroscopy (CMDMS) is driven by a desire to investigate heterogenous samples and spatially resolve details about molecular structure and dynamics that are available using coherent multidimensional techniques (CMDS). However, incorporating traditional CMDS techniques into imaging modalities requires tackling obstacles including acquisition time, spatial resolution, and detection methods. Thus, this chapter reviews these challenges, the basics of microscopy and spatial resolution, and how different experimental setups implemented by the five research groups that have executed CMDMS approach these obstacles. In addition to a brief review of experimental set-ups, the main findings of each group are reviewed. Most of the current research is shown to be proof of concept, however with additional improvements valuable information could be gained about different biological and materials samples. In looking towards the future of the field, this chapter also reviews other methods for data reduction and detection methods that have been applied in CMDS experiments such as compressive sensing and fluorescence detection or fluorescence encoding methods to combat long acquisition times, IR detection limitations, and the diffraction limited spatial resolution inherent to the mid-IR.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
D. Bardell, The biologists’ forum: the invention of the microscope. bios 75, 78–84 (2004). https://doi.org/10.1893/0005-3155(2004)75%3c78:TIOTM%3e2.0.CO;2 (2004)
J.A. Kimber, S.G. Kazarian, Spectroscopic imaging of biomaterials and biological systems with FTIR microscopy or with quantum cascade lasers. Anal. Bioanal. Chem. 409, 5813–5820 (2017). https://doi.org/10.1007/s00216-017-0574-5
S. Prati, E. Joseph, G. Sciutto, R. Mazzeo, New advances in the application of FTIR microscopy and spectroscopy for the characterization of artistic materials. Acc. Chem. Res. 43, 792–801 (2010). https://doi.org/10.1021/ar900274f
L.M. Miller, M.W. Bourassa, R.J. Smith, FTIR spectroscopic imaging of protein aggregation in living cells. Biochimica et Biophysica Acta (BBA) - Biomembranes 1828, 2339–2346 (2013). https://doi.org/10.1016/j.bbamem.2013.01.014 (2013)
F. Helmchen, W, Denk, Deep tissue two-photon microscopy. Nat. Methods 2, 932–940 (2005). https://doi.org/10.1038/NMETH818
J. Squier, M. Müller, High resolution nonlinear microscopy: a review of sources and methods for achieving optimal imaging. Rev. Sci. Instrum. 72, 2855–2867 (2001). https://doi.org/10.1063/1.1379598
R. Carriles, D.N. Schafer, K.E. Sheetz, et al., Invited review article: imaging techniques for harmonic and multiphoton absorption fluorescence microscopy. Rev. Sci. Instrum. 80, 081101 (2009). https://doi.org/10.1063/1.3184828
D.J. Kissick, D. Wanapun, G.J. Simpson, Second-order nonlinear optical imaging of chiral crystals. Annu. Rev. Anal. Chem. 4, 419–437 (2011). https://doi.org/10.1146/annurev.anchem.111808.073722
R.J. Tran, K.L. Sly, J.C. Conboy, Applications of surface second harmonic generation in biological sensing. Annu. Rev. Anal. Chem. 10, 387–414 (2017). https://doi.org/10.1146/annurev-anchem-071015-041453
J.P.R. Day, K.F. Domke, G. Rago et al., Quantitative Coherent Anti-Stokes Raman Scattering (CARS) Microscopy. J. Phys. Chem. B 115, 7713–7725 (2011). https://doi.org/10.1021/jp200606e
C.L. Evans, X.S. Xie, Coherent Anti-Stokes Raman scattering microscopy: chemical imaging for biology and medicine. Annu. Rev. Anal. Chem. 1, 883–909 (2008). https://doi.org/10.1146/annurev.anchem.1.031207.112754
D. Polli, V. Kumar, C.M. Valensise et al., Broadband coherent Raman Scattering Microscopy. Laser Photonics Rev. 12, 1800020 (2018). https://doi.org/10.1002/lpor.201800020
A. Hanninen, M.W. Shu, E.O. Potma, Hyperspectral imaging with laser-scanning sum-frequency generation microscopy. Biomed Opt. Express 8, 4230–4242 (2017). https://doi.org/10.1364/BOE.8.004230
C.M. Lee, K. Kafle, S. Huang, S.H. Kim, Multimodal broadband vibrational sum frequency generation (MM-BB-V-SFG) spectrometer and microscope. J. Phys. Chem. B. 120, 102–116 (2016). https://doi.org/10.1021/acs.jpcb.5b10290
Y. Li, D. Chen, H. Niu, A method for achieving super resolution vibrational sum-frequency generation microscopy by structured illumination. IEEE Photonics J. 9, 1–8 (2017). https://doi.org/10.1109/JPHOT.2017.2705124
R. Heintzmann, G. Ficz, Breaking the resolution limit in light microscopy. Brief. Func. Genomics 5, 289–301 (2006). https://doi.org/10.1093/bfgp/ell036
J. Squier, M. Müller, High resolution nonlinear microscopy: a review of sources and methods for achieving optimal imaging High resolution nonlinear microscopy: a review of sources and methods for achieving optimal imaging. Rev. Sci. Instrum. 2855, 2855–2867 (2001). https://doi.org/10.1063/1.1379598
P. Hamm, M. Zanni, Concepts and Methods of 2D Infrared Spectroscopy. (Cambridge University Press, 2011)
S. Mukamel, Principles of Nonlinear Optical Spectroscopy (Oxford University Press, New York, 1999)
P.F. Tekavec, G.A. Lott, A.H. Marcus, Fluorescence-detected two-dimensional electronic coherence spectroscopy by acousto-optic phase modulation Fluorescence-detected two-dimensional electronic coherence spectroscopy by acousto-optic phase modulation. J. Chem. Phys. 127, 214307 (2007). https://doi.org/10.1063/1.2800560
B.M. Luther, K.M. Tracy, M. Gerrity et al., 2D IR spectroscopy at 100 kHz utilizing a Mid- IR OPCPA laser source. Opt. Express 24, 10095–10100 (2016). https://doi.org/10.1364/OE.24.004117
C.R. Baiz, D. Schach, A. Tokmakoff, Ultrafast 2D IR microscopy. Opt. Express 22, 875–885 (2014). https://doi.org/10.1364/OE.22.018724
D. Keusters, H. Tan, W.S. Warren, Role of Pulse Phase and Direction in Two-Dimensional Optical Spectroscopy. J. Phys. Chem. A 103, 10369–10380 (1999). https://doi.org/10.1021/jp992325b
W. Wagner, C. Li, J. Semmlow, W. Warren, Rapid phase-cycled two-dimensional optical spectroscopy in fluorescence and transmission mode. Opt. Express 13, 3697–3706 (2005). https://doi.org/10.1364/OPEX.13.003697
S. Shim, M.T. Zanni, How to turn your pump—probe instrument into a multidimensional spectrometer: 2D IR and vis spectroscopies via pulse shaping. Phys. Chem. Chem. Phys. 11, 748–761 (2009). https://doi.org/10.1039/b813817f
S. Draeger, S. Roeding, T. Brixner, Rapid-scan coherent 2D fluorescence spectroscopy. Opt. Express 25, 3259 (2017). https://doi.org/10.1364/OE.25.003259
S. Goetz, D. Li, V. Kolb et al., Coherent two-dimensional fluorescence micro-spectroscopy. Opt. Express 26, 3915 (2018). https://doi.org/10.1364/OE.26.003915
V. Tiwari, Y.A. Matutes, A.T. Gardiner, et al., Spatially-resolved fluorescence-detected two-dimensional electronic spectroscopy probes varying excitonic structure in photosynthetic bacteria. Nat. Commun. 9, 4219 (2018) https://doi.org/10.1038/s41467-018-06619-x
J. Almeida, J. Prior, M.B. Plenio, Computation of two-dimensional spectra assisted by compressed sampling. J. Phys. Chem. Lett. 3, 2692–2696 (2012). https://doi.org/10.1021/jz3009369
J.N. Sanders, S.K. Saikin, S. Mostame, et al., Compressed sensing for multidimensional spectroscopy experiments. J. Phys. Chem. Lett. 3, 2697–2702 (2012). https://doi.org/10.1021/jz300988p
J.A. Dunbar, D.G. Osborne, J.M. Anna, K.J. Kubarych, Accelerated 2D-IR using compressed sensing. J. Phys. Chem. Lett. 4, 2489–2492 (2013). https://doi.org/10.1021/jz401281r
S.T. Roberts, J.J. Loparo, A. Tokmakoff, Characterization of spectral diffusion from two-dimensional line shapes. J. Chem. Phys. 125, 084502 (2006). https://doi.org/10.1063/1.2232271
J.S. Ostrander, A.L. Serrano, A. Ghosh, M.T. Zanni, Spatially resolved two-dimensional infrared spectroscopy via wide- field microscopy. ACS Photonics 3, 1315–1323 (2016). https://doi.org/10.1021/acsphotonics.6b00297
P.M. Donaldson, G.M. Greetham, D.J. Shaw et al., A 100 kHz pulse shaping 2D-IR spectrometer based on dual Yb:KGW amplifiers. J. Phys. Chem. A 122, 780–787 (2018). https://doi.org/10.1021/acs.jpca.7b10259
N.M. Kearns, R.D. Mehlenbacher, A.C. Jones, M.T. Zanni, Broadband 2D electronic spectrometer using white light and pulse shaping: noise and signal evaluation at 1 and 100 kHz. Opt. Express 25, 7869 (2017). https://doi.org/10.1364/OE.25.007869
K.M. Tracy, B. Guchhait, C.A. Tibbetts, et al., Visualizing chemical dynamics in an ionic liquid microdroplet using ultrafast 2DIR microscopy. In preparation (2019)
A.K. De, D. Monahan, J.M. Dawlaty, G.R. Fleming, Two-dimensional fluorescence-detected coherent spectroscopy with absolute phasing by confocal imaging of a dynamic grating and 27-step phase-cycling. J. Chem. Phys. 140, 194201 (2014). https://doi.org/10.1063/1.4874697
G.A. Lott, A. Perdomo-ortiz, J.K. Utterback, et al., Conformation of self-assembled porphyrin dimers in liposome vesicles by phase-modulation 2D fluorescence spectroscopy. Proc. Natl. Acad. Sci. USA, 108, 16521–16526 (2011). https://doi.org/10.1073/pnas.1017308108
J.N. Mastron, A. Tokmako, Fourier transform fluorescence-encoded infrared spectroscopy. J. Phys. Chem. A 122, 554–562 (2018). https://doi.org/10.1021/acs.jpca.7b10305
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Tibbetts, C.A., Luther, B.M., Krummel, A.T. (2019). The Development of Coherent Multidimensional Microspectroscopy. In: Cho, M. (eds) Coherent Multidimensional Spectroscopy. Springer Series in Optical Sciences, vol 226. Springer, Singapore. https://doi.org/10.1007/978-981-13-9753-0_14
Download citation
DOI: https://doi.org/10.1007/978-981-13-9753-0_14
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-9752-3
Online ISBN: 978-981-13-9753-0
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)