Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder and one of the substantial socioeconomic and medical calamities of our time. It is characterized by progressive neurodegenerative disorder featuring dementia and cognitive impairment. It is caused by synaptic failure and the excessive aggregation of two types of misfolded proteins, namely, amyloid-β (Aβ) and tau protein. AD is a complex disease that affects neurons in different parts of the brain. The treatment of AD is difficult with currently available medications and treatment approaches due to inadequate knowledge of its etiology and versatile nature of its pathology. Stem cell holds a promising approach to regenerate the tissue systems and has been explored in various studies of neurodegenerative disorders and provides great research opportunity. Stem cell research-based therapies emit a new hope for AD treatment as a regenerative approach. This chapter focuses on recent advances in stem cell therapies according to cell types and pathophysiology of AD along with human clinical trials of stem cell therapies for the AD.
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This work is supported by SERB (EEQ/2018/000114) grant.
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Tabassum, N., Yadav, C.B., Singh, A., Verma, V. (2019). Stem Cell Therapy: A Great Leap Forward in Alzheimer’s Treatment. In: Ashraf, G., Alexiou, A. (eds) Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-9636-6_9
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