Biotechnology and Bioinformatics Applications in Alzheimer’s Disease

  • Mahmoud A. AliEmail author
  • Athanasios Alexiou
  • Ghulam Md Ashraf


Alzheimer’s disease is one of the most severe types of dementia that causes problems with memory, thinking, and behavior. Biotechnology and bioinformatics are nowadays involved in the establishment of advanced methods of diagnosis and treatment, including molecular medicine, personalized medicine, gene identification and manipulation, as well as neural engineering. Next-generation sequencing is one of the strongest tools for studying genetic diseases and gene mutations. Additionally, brain-computer interface could be used in the near future to assist people with paralysis or other related disorders and physical injuries to move toward into a better way of life, restoring memory or improving the way of everyday life. This chapter aims to provide an overview of the most common and an advanced application of biotechnology and bioinformatics in Alzheimer’s including the genome-wide association studies and the role of microbiome detection in Alzheimer’s disease.


Algorithms in biology Alzheimer’s disease Bioinformatics Brain-computer interface Genome-wide association study Next-generation sequencing Neural engineering 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Mahmoud A. Ali
    • 1
    Email author
  • Athanasios Alexiou
    • 2
    • 3
  • Ghulam Md Ashraf
    • 4
    • 5
  1. 1.Biotechnology Program, Faculty of AgricultureCairo UniversityGizaEgypt
  2. 2.Novel Global Community Educational FoundationHebershamAustralia
  3. 3.AFNP MedWienAustria
  4. 4.King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia
  5. 5.Department of Medical Laboratory Technology, Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddahSaudi Arabia

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