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Transcriptional Engineering for Enhancing Valuable Components in Photosynthetic Microalgae

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Abstract

Photosynthetic microalgae can accumulate a wide array of valuable components. However, higher titer of desired product usually occurs under sub-optimal conditions with the compromise of cellular biomass, which seriously hindered their commercial applications. Conventional metabolic engineering has been employed by targeted perturbation of selected genes in the metabolic pathway without compromising cellular growth. Nevertheless, previous studies have shown mixed and inconsistent success owing to the intricate nature of the target metabolic pathways. Transcriptional engineering represents a promising strategy to govern multiple metabolic pathways by regulation of critical transcription factors, thereby controlling the expression of target gene(s). It has exhibited potential significance and advancements in synthetic biology for microalgal strain improvement. In this chapter, we focus on the significance and status of transcriptional engineering strategies and also speculate on future development to enhance production of microalgal valuable components.

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Authors and Affiliations

  1. Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou, China

    Srinivasan Balamurugan, Da-Wei Li, Xiang Wang, Wei-Dong Yang, Jie-Sheng Liu & Hong-Ye Li

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  1. Srinivasan Balamurugan
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  2. Da-Wei Li
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  3. Xiang Wang
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  4. Wei-Dong Yang
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  5. Jie-Sheng Liu
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  6. Hong-Ye Li
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Correspondence to Hong-Ye Li .

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Editors and Affiliations

  1. Plant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India

    Ramalingam Sathishkumar

  2. String Bio Private Ltd, IBAB Campus, Bangalore, India

    Sarma Rajeev Kumar

  3. Department of Biotechnology, PSG College of Technology, Coimbatore, Tamil Nadu, India

    Jagadeesan Hema

  4. Plant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India

    Venkidasamy Baskar

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Balamurugan, S., Li, DW., Wang, X., Yang, WD., Liu, JS., Li, HY. (2019). Transcriptional Engineering for Enhancing Valuable Components in Photosynthetic Microalgae. In: Sathishkumar, R., Kumar, S., Hema, J., Baskar, V. (eds) Advances in Plant Transgenics: Methods and Applications. Springer, Singapore. https://doi.org/10.1007/978-981-13-9624-3_16

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