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Circulation of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Nature: Transmission of SFTSV Between Mammals and Ticks

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS virus (SFTSV), a novel phlebovirus, was reported to be endemic to central and northeastern China, South Korea, and Japan. SFTS is a tick-borne viral infection with high morbidity and mortality. SFTSV is circulating in nature in the SFTS-endemic areas. SFTSV is maintained in nature between animals and some species of ticks. Humans are usually infected with SFTSV by virus-positive ticks, especially Haemaphysalis longicornis and Amblyomma testudinarium. The mechanism of SFTSV maintenance in nature is crucial to control SFTSV infections in humans. Antibody positive rates to SFTSV in some species of animals such as goats, deer, old aged bovine, and wild boar were reported to be relatively high. Virus genomes were detected in some species of ticks such as H. longicornis, H. flava, H. concinna, A. testudinarium, and Ixodes nipponensis. Animal species, which were studied for SFTSV antibody and SFTSV genome prevalence, are still limited. Based on the data reported so far suggest that SFTSV is maintained in nature through intensive transmission between animals such as goats, deer, and wild boars and Haemaphysalis, Ambryomma, and Ixodes ticks. Further studies are needed to clarify the SFTSV maintenance mechanism in nature in detail.

Keywords

  • Severe fever with thrombocytopenia syndrome
  • Novel bunyavirus
  • Severe fever with thrombocytopenia syndrome virus
  • Ticks
  • Animals

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Fig. 13.1

References

  • Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M (2013) Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antivir Res 100:159–189

    CAS  Google Scholar 

  • Cyranoski D (2018) East Asia braces for surge in deadly tick-borne virus. Nature 556:282–283

    CAS  CrossRef  Google Scholar 

  • Ham H, Jo S, Jang J, Choi S (2014) No detection of severe fever with thrombocytopenia syndrome virus from ixodid ticks collected in Seoul. Korean J Parasitol 52:221–224

    CrossRef  Google Scholar 

  • Hayasaka D, Shimada S, Aoki K, Takamatsu Y, Uchida L, Horio M, Fuxun Y, Morita K (2015) Epidemiological survey of severe fever with thrombocytopenia syndrome virus in ticks in Nagasaki, Japan. Trop Med Health 43:159–164

    CrossRef  Google Scholar 

  • Hayasaka D, Fuxun Y, Yoshikawa A, Posadas-Herrera G, Shimada S, Tun MM, Agoh M, Morita K (2016) Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan. Trop Med Health 44:6

    CrossRef  Google Scholar 

  • Hwang J, Kang JG, Oh SS, Chae JB, Cho YK, Cho YS, Lee H, Chae JS (2017) Molecular detection of severe fever with thrombocytopenia syndrome virus (SFTSV) in feral cats from Seoul, Korea. Ticks Tick-Borne Dis 8:9–12

    CrossRef  Google Scholar 

  • Jo YS, Kang JG, Chae JB, Cho YK, Shin JH, Jheong WH, Chae JS (2018) Prevalence of severe fever with thrombocytopenias syndrome virus in ticks collected from national parks in Korea. Vector Borne Zoonotic Dis 19:284–289

    CrossRef  Google Scholar 

  • Kang JG, Cho YK, Jo YS, Chae JB, Oh SS, Kim KH, Ko MK, Yi J, Choi KS, Yu DH, Kim HC, Park J, Park BK, Choi CY, Jung YH, Chae JS (2018a) Prevalence of severe fever with thrombocytopenia syndrome virus in black goats (Capra hircus coreanae) in the Republic of Korea. Ticks Tick-Borne Dis 9:1153–1157

    CrossRef  Google Scholar 

  • Kang JG, Oh SS, Jo YS, Chae JB, Cho YK, Chae JS (2018b) Molecular detection of severe fever with thrombocytopenia syndrome virus in Korean domesticated pigs. Vector Borne Zoonotic Dis 18:450–452

    CrossRef  Google Scholar 

  • Kato H, Yamagishi T, Shimada T, Matsui T, Shimojima M, Saijo M, Oishi K (2016) Epidemiological and clinical features of severe fever with thrombocytopenia syndrome in Japan, 2013–2014. PLoS One 11:e0165207

    CrossRef  Google Scholar 

  • Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, Choe PG, Kim NJ, Lee JK, Oh MD (2013) Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19:1892–1894

    CrossRef  Google Scholar 

  • Lee SH, Kim HJ, Byun JW, Lee MJ, Kim NH, Kim DH, Kang HE, Nam HM (2017) Molecular detection and phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in shelter dogs and cats in the Republic of Korea. Ticks Tick-Borne Dis 8:626–630

    CrossRef  Google Scholar 

  • Lee SH, Kim HJ, Lee MJ, Byun JW, Kim DY, Kim NH, Kim DH, Kwak D, Kang HE, Nam HM (2018) Prevalence of antibodies against severe fever with thrombocytopenia syndrome virus in shelter dogs in the Republic of Korea. Ticks Tick-Borne Dis 9:183–187

    CAS  CrossRef  Google Scholar 

  • Li Z, Bao C, Hu J, Liu W, Wang X, Zhang L, Ji Z, Feng Z, Li L, Shen A, Liu X, Zhao H, Tan W, Zhou J, Qi X, Zhu Y, Tang F, Cardona CJ, Xing Z (2016) Ecology of the tick-borne phlebovirus causing severe fever with thrombocytopenia syndrome in an endemic area of China. PLoS Negl Trop Dis 10:e0004574

    CrossRef  Google Scholar 

  • Liu H, Li Z, Wang Z, He B, Wang S, Wei F, Tu C, Liu Q (2016) The first molecular evidence of severe fever with thrombocytopenia syndrome virus in ticks in Jilin, Northeastern China. Ticks Tick-Borne Dis 7:1280–1283

    CrossRef  Google Scholar 

  • Luo LM, Zhao L, Wen HL, Zhang ZT, Liu JW, Fang LZ, Xue ZF, Ma DQ, Zhang XS, Ding SJ, Lei XY, Yu XJ (2015) Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. Emerg Infect Dis 21:1770–1776

    CAS  CrossRef  Google Scholar 

  • Matsuno K, Nonoue N, Noda A, Kasajima N, Noguchi K, Takano A, Shimoda H, Orba Y, Muramatsu M, Sakoda Y, Takada A, Minami S, Une Y, Morikawa S, Maeda K (2018) Fatal tickborne phlebovirus infection in captive cheetahs, Japan. Emerg Infect Dis 24:1726–1729

    CAS  CrossRef  Google Scholar 

  • Meng K, Sun W, Cheng Z, Guo H, Liu J, Chai T (2015) First detection of severe fever with thrombocytopenia syndrome virus in the tick species Haemaphysalis concinna in Shandong Province, China. Parasitol Res 114:4703–4707

    CrossRef  Google Scholar 

  • Noguchi K, Tatemoto K, Minami S, Yonomitsu K, Supriyano S, Ngo TTB, Mizuno J, Kuwata R, Takano A, Shimoda H, Soma T, Morikawa S, Maeda K (2018) Occurence situations of SFTS among cats and dogs in Japan (2017) (W1-4-19). In: The 66th Annual Meeting of the Japanes Society for Virology, Kyoto, Japan, p 164

    Google Scholar 

  • Oh SS, Chae JB, Kang JG, Kim HC, Chong ST, Shin JH, Hur MS, Suh JH, Oh MD, Jeong SM, Shin NS, Choi KS, Chae JS (2016) Detection of severe fever with thrombocytopenia syndrome virus from wild animals and Ixodidae ticks in the Republic of Korea. Vector Borne Zoonotic Dis 16:408–414

    CrossRef  Google Scholar 

  • Park SW, Song BG, Shin EH, Yun SM, Han MG, Park MY, Park C, Ryou J (2014) Prevalence of severe fever with thrombocytopenia syndrome virus in Haemaphysalis longicornis ticks in South Korea. Ticks Tick-Borne Dis 5:975–977

    CrossRef  Google Scholar 

  • Saijo M, Shimojima M, Okumura H, Goto H, Maeda K, Morikawa S (2018) A patient with severe fever with thrombocytopenia syndrome, who was infected with close contact with sick dog, which was diagnoses as having SFTS virus infection (O1-079). In: The 92th annual meeting of the Japanese Association for Infectious Diseases, Okayama, Japan. The Japanese Association for Infectious Diseases, p 727 (in Japanese, translated by the author)

    Google Scholar 

  • Sun Y, Liu MM, Luo LM, Zhao L, Wen HL, Zhang ZT, Liu JW, Xue ZF, Ma DQ, Ding SJ, Lei XY, Yu XJ (2017) Seroprevalence of severe fever with thrombocytopenia syndrome virus in hedgehog from China. Vector Borne Zoonotic Dis 17:347–350

    CrossRef  Google Scholar 

  • Tabara K, Fujita H, Hirata A, Hayasaka D (2016) Investigation of severe fever with thrombocytopenia syndrome virus antibody among domestic bovines transported to slaughterhouse in Shimane prefecture, Japan. Jpn J Infect Dis 69:445–447

    CAS  CrossRef  Google Scholar 

  • Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M (2014) The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209:816–827

    CAS  CrossRef  Google Scholar 

  • Tian H, Yu P, Chowell G, Li S, Wei J, Lv W, Han Z, Yang J, Huang S, Zhou S, Brownstein JS, Wang J, Xu B (2017) Severe fever with thrombocytopenia syndrome virus in humans, domesticated animals, ticks, and mosquitoes, Shaanxi Province, China. Am J Trop Med Hyg 96:1346–1349

    CrossRef  Google Scholar 

  • Tsuru M, Matsui K, Tokunaga M, Tanaka S, Saijo M, Shimojima M, Murakami T (2018) A patient with severe fever with thrombotytopenia syndrome (SFTS), who was considered to be infected with SFTS virus through cat-bite (O1-068). In: The 92th annual meeting of the Japanese Association for Infectious Diseases, Okayama, Japan. The Japanese Association for Infectious Diseases, p 724 (in Japanese, translated by the author)

    Google Scholar 

  • Xu B, Liu L, Huang X, Ma H, Zhang Y, Du Y, Wang P, Tang X, Wang H, Kang K, Zhang S, Zhao G, Wu W, Yang Y, Chen H, Mu F, Chen W (2011) Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog 7:e1002369

    CAS  CrossRef  Google Scholar 

  • Yang L, Zhao Z, Hou G, Zhang C, Liu J, Xu L, Li W, Tan Z, Tu C, He B (2019) Genomes and seroprevalence of severe fever with thrombocytopenia syndrome virus and Nairobi sheep disease virus in Haemaphysalis longicornis ticks and goats in Hubei, China. Virology 529:234–245

    CAS  CrossRef  Google Scholar 

  • Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX (2011) Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364:1523–1532

    CAS  CrossRef  Google Scholar 

  • Yun SM, Lee YJ, Choi W, Kim HC, Chong ST, Chang KS, Coburn JM, Klein TA, Lee WJ (2016) Molecular detection of severe fever with thrombocytopenia syndrome and tick-borne encephalitis viruses in ixodid ticks collected from vegetation, Republic of Korea, 2014. Ticks Tick-Borne Dis 7:970–978

    CrossRef  Google Scholar 

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Correspondence to Masayuki Saijo .

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Saijo, M. (2019). Circulation of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Nature: Transmission of SFTSV Between Mammals and Ticks. In: Saijo, M. (eds) Severe Fever with Thrombocytopenia Syndrome. Springer, Singapore. https://doi.org/10.1007/978-981-13-9562-8_13

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