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Seroprevalence and Risk Factors of Severe Fever with Thrombocytopenia Syndrome

Seroepidemiology of SFTS

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Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). This phlebovirus was first reported to cause this disease in 2011 in China. Since its identification, serological surveys of the healthy human population and domesticated and wild animals in China, Japan, and South Korea have been conducted. This literature review shows that the SFTSV seroprevalence in healthy people ranges from 0% to 10.5% and depends on age, occupation, living area, and tick-bite history. High rates of antibody positivity have been detected in many domesticated and wild animals. Thus, these animals may act as amplifying hosts of the virus. The implications and challenges facing the seroepidemiology of this novel bunyavirus are discussed.

Keywords

  • SFTS
  • Seroepidemiology
  • ELISA
  • IFA
  • Neutralization test

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Acknowledgments

I thank Drs. Masayuki Saijo, Masayuki Shimojima, Takeshi Kurosu, Tomoki Yoshikawa, Shumpei Watanabe, Hideki Tani, and Aiko Fukuma (Department of Virology 1, NIID) for helpful discussions.

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Correspondence to Shuetsu Fukushi .

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© 2019 Springer Nature Singapore Pte Ltd.

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Fukushi, S. (2019). Seroprevalence and Risk Factors of Severe Fever with Thrombocytopenia Syndrome. In: Saijo, M. (eds) Severe Fever with Thrombocytopenia Syndrome. Springer, Singapore. https://doi.org/10.1007/978-981-13-9562-8_10

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