Abstract
Rhinosinusitis is the inflammation of nose and sinuses. In the disease process, the inflamed and swelled mucous membrane of nose and paranasal sinuses obstructs the sinus opening and prevents mucous from draining normally, leading to pain, nasal blockade, swelling, fetid discharge. The course of the disease may be acute or chronic depending on the etiological agents and host immunity. Fungus as a cause of rhinosinusitis has gained importance in last two decades. It may cause rhinosinusitis either by allergic inflammatory process or by direct infection. Fungal rhinosinusitis (FRS) is common in Asian countries especially India, Pakistan, and Saudi Arabia [1–8]. The disease may be prevalent in other Asian countries, but the prevalence is not known due to the absence of studies. In a study in the villages of North India, it was observed that 1.4% of young adults suffer from chronic rhinosinusitis (CRS). The prevalence of FRS was 0.11% of population and 8.1% of all CRS cases [9]. A great deal of controversy exists regarding etiology and pathogenesis of CRS. The claims of scientists range from fungi are only bystanders to all CRS cases are due to fungi [2, 3]. Attempts have been made by researchers to resolve the controversy, as therapy varies in different categories of rhinosinusitis. CRS affects nearly 20% of population at some time in their lives [3, 10, 11]. Scientists broadly classify FRS into invasive and noninvasive diseases depending on the invasion of nasal and paranasal sinus tissues by fungi. Depending on the immune status and histopathology, invasive disease is further differentiated into acute invasive, granulomatous invasive, and chronic invasive type. The noninvasive FRS is described in four different clinical forms: localized colonization, fungal ball, allergic fungal rhinosinusitis (AFRS), and eosinophilic fungal rhinosinusitis (EFRS) [2, 3, 12]. The descriptions of all these entities are summarized in Table 11.1. In Asian countries the common clinical form are AFRS, EFRS, and granulomatous invasive types in immunocompetent hosts [1–8].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Zakirullah, Nawaz G, Sattar SF. Presentation and diagnosis of allergic fungal sinusitis. J Ayub Med Coll Abbottabad. 2010;22:53–7.
Chakrabarti A, Das A, Panda NK. Controversies surrounding the categorization of fungal sinusitis. Med Mycol. 2009;47(Suppl I):S299–308.
Arunaloke C, Denning David W, Ferguson Berrylin J, Jens P, Walter B, Hirohito K, Bradley M, Naresh P, Stephan V, Catherine K-L, Ashim D, Paramjeet S, Taj-Aldeen Saad J, Serda KA, Handa Kumud K, Ashok G, Thungapathra M, Shivaprakash Mandya R, Amanjit B, Annette F, Radotra Bishan D. Fungal rhinosinusitis: a categorization and definitional schema addressing current controversies. Laryngoscope. 2009;119:1809–18. Telmesani LM. Prevalence of allergic fungal sinusitis among patients with nasal polyps. Ann Saudi Med. 2009; 29: 212-4.
Saravanan K, Panda NK, Chakrabarti A, Das A, Bapuraj RJ. Allergic fungal rhinosinusitis: an attempt to resolve the diagnostic dilemma. Arch Otolaryngol Head Neck Surg. 2006;132:173–8.
Siddiqui AA, Shah AA, Bashir SH. Craniocerebral aspergillosis of sinonasal origin in immunocompetent patients: clinical spectrum and outcome in 25 cases. Neurosurgery. 2004;55:602–11.
Panda NK, Sharma SC, Chakrabarti A, Mann SBS. Paranasal sinus mycoses in north India. Mycoses. 1998;41:281–6.
Chakrabarti A, Sharma SC, Chander J. Epidemiology and pathogenesis of paranasal sinus mycoses. Otolaryngol Head Neck Surg. 1992;107:745–50.
Chakrabarti A, Rudramurthy SM, Panda N, Das A, Singh A. Epidemiology of chronic fungal rhinosinusitis in rural India. Mycoses. 2015;58:294–302.
Meltzer E, Hamilos D, Hadley J, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004;114(suppl):S155–212.
International Rhinosinusitis Advisory Board. Infectious rhinosinusitis in adults: classification, etiology and management. Ear Nose Throat J. 1997;76:5–22.
Das A, Bal A, Chakrabarti A, Panda N, Joshi K. Spectrum of fungal rhinosinusitis; histopathologist’s perspective. Histopathology. 2009;54:854–9.
Veress B, Malik OA, el-Tayeb AA, el-Daoud S, Mahgoub ES, el-Hassan AM. Further observations on primary paranasal Aspergillus granuloma in the Sudan. A morphological study of 46 cases. Am J Trop Med Hyg. 1973;2:765–72.
deShazo RD, Chapin K, Swain R. Fungal sinusitis. N Engl J Med. 1997;337:254–9.
Milroy CM, Blanshard JD, Lucas S, Michaels L. Aspergillosis of the nose and paranasal sinuses. J Clin Pathol. 1989;42:123–7.
Ferguson BJ. Definitions of fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:227–35.
Grosjean P, Weber R. Fungus balls of the paranasal sinuses: a review. Eur Arch Otorhinolaryngol. 2007;264:461–70.
Jiang RS, Huang WC, Liang KL. Characteristics of sinus fungus ball: a unique form of rhinosinusitis. Clin Med Insights Ear Nose Throat. 2018;11:1179550618792254.
Gungor A, Adusumilli V. Fungal sinusitis: progression of diseases in immunosuppression—a case report. Ear Nose Throat J. 1998;77:207–15.
Graham SM, Ballas ZK. Postoperative steroids confuse the diagnosis of allergic fungal sinusitis. J Allergy Clin Immunol. 1998;101:139–40.
Safirstein B. Allergic broncho-pulmonary aspergillosis with obstruction of the upper respiratory tract. Chest. 1976;70:788–90.
Millar JN, Johnston A, Lamb D. Allergic aspergillosis of the maxillary sinuses. Thorax. 1981;36:710.
Katzenstein AA, Sole SR, Greenberger PA. Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol. 1983;72:82–93.
Bent JP, Kuhn FA. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1994;111:580–8.
Ponikau JU, Sherris DA, Kern EB, Homburger HA, Frigas E, Gaffey TA. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc. 1999;74:877–84.
Braun H, Buzina W, Freudenschuss K, Beham A, Stammberger H. “Eosinophilic fungal rhinosinusitis”: a common disorder in Europe? Laryngoscope. 2003;113:264–9.
Ponikau JU, Sherris DA, Kephart GM, et al. Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis. J Allergy Clin Immunol. 2005;116:362–9.
Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: an advanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004;114:1369–75.
Orlandi RR, Marple BF, Georgelas A, Durtschi D, Barr L. Immunologic response to fungus is not universally associated with rhinosinusitis. Otolaryngol Head Neck Surg. 2009;141:750–6.
Ferguson BJ. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2000;110:799–813.
Lackner A, Stammberger H, Buzina W, et al. Fungi: a normal content of human nasal mucus. Am J Rhinol. 2005;19:125–9.
Murr AH, Goldberg AN, Pletcher SD, Dillehay K, Wymer LJ, Vesper SJ. Some chronic rhinosinusitis patients have elevated populations of fungi in their sinuses. Laryngoscope. 2012;122:1438–45.
Guo C, Ghaderoshi S, Kephart GM, et al. Improving the detection of fungi in eosinophilic mucin: seeing what we could not see before. Otolaryngol Head Neck Surg. 2012;147:943–9.
Orlandi RR, Thibeault SL, Ferguson BJ. Microarray analysis of allergic fungal sinusitis and eosinophilic muin rhinosinusitis. Otolaryngol Head Neck Surg. 2007;136:707–13.
Collins M, Nair S, Smith W, Kette F, Gillis D, Wormald PJ. Role of local immunoglobulin E production in the pathophysiology of noninvasive fungal sinusitis. Laryngoscope. 2004;114:1242–6.
Pant H, Kette FE, Smith WB, Wormald PJ, Macardle PJ. Fungal-specific humoral response in eosinophilic mucus chronic rhinosinusitis. Laryngoscope. 2005;115:601–6.
Thakar A, Sarkar C, Dhiwakar M, Bahadur S, Dahiya S. Allergic fungal sinusitis: expanding the clinicopathological spectrum. Otolaryngol Head Neck Surg. 2004;130:209–16.
Borish L, Rosenwasser L, Steinke JW. Fungi in chronic hyperplastic eosinophilic sinusitis. Clin Rev Allergy Immunol. 2006;30:1–9.
deShazo RD, Swain RE. Diagnostic criteria for allergic fungal sinusitis. J Allergy Clin Immunol. 1995;96:24–35.
Glass D, Amedee RG. Allergic fungal rhinosinusitis: a review. Ochsner J. 2011;11:271–5.
Kale P, Rudramurthy SM, Panda N, Das A, Chakrabarti A. The inflammatory response of eosinophil-related fungal rhinosinusitis varies with inciting fungi. Med Mycol. 2015;53:387–95.
Marple BF, Gibbs SR, Newcomer MT, Mabry RL. Allergic fungal sinusitis-induced visual loss. Am J Rhinol. 1999;13:191–5.
Manning SC, Schaefer SD, Close LG, Vuitch F. Culture positive allergic fungal sinusitis. Arch Otolaryngol. 1991;117:174–8.
Cody DT, Neel HB, Ferreiro JA, Roberts GD. Allergic fungal sinusitis: the Mayo Clinic experience. Laryngoscope. 1994;104:1074–9.
Kuhn FA, Javer AR. Allergic fungal rhinosinusitis: our experience. Arch Otolaryngol Head Neck Surg. 1998;124:1179–80.
Ryan MW, Marple BF. Allergic fungal rhinosinusitis: diagnosis and management. Curr Opin Otolaryngol Head Neck Surg. 2007;15:18–22.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Chakrabarti, A. (2020). Fungal Rhinosinusitis. In: Chakrabarti, A. (eds) Clinical Practice of Medical Mycology in Asia. Springer, Singapore. https://doi.org/10.1007/978-981-13-9459-1_11
Download citation
DOI: https://doi.org/10.1007/978-981-13-9459-1_11
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-9458-4
Online ISBN: 978-981-13-9459-1
eBook Packages: MedicineMedicine (R0)