Abstract
In this chapter, the first kinetic resolution of α-hydroxy thioamide using a new aminoindane-based triazolium salt and low acidic carboxylic acid cocatalyst was described.
Chiral recognization of substrate–cocatalyst complex is the crux of this reaction. Further transformation using the resulting enantiopure α-hydroxy thioamide was also investigated.
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Wang, Y. (2019). Kinetic Resolution of α-Hydroxy Carboxylic Acid Derivatives Based on Chiral Recognition of Substrate–Cocatalyst Complex. In: Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-13-9398-3_3
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DOI: https://doi.org/10.1007/978-981-13-9398-3_3
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