The Application of Urinary Proteomics in Early Detection of Digestive Diseases

Zhang, Linpei; Zhang, Fanshuang; Qin, Weiwei

doi:10.1007/978-981-13-9109-5_16

Linpei Zhang²,
Fanshuang Zhang³ &
Weiwei Qin⁴

439 Accesses

Abstract

Digestive diseases are disorders of the digestive organs, which may range from benign to serious. There is an inherent difficulty in diagnosis and treatment of various chronic digestive diseases; thus noninvasive early biomarkers are desperately needed. Without homeostasis mechanisms, urine is an ideal biomarker source that can reflect the early changes of disease theoretically. In this section, we will introduce the new studies of the urine proteome in rat models of three digestive diseases including liver fibrosis, chronic pancreatitis and inflammatory bowel disease. Many potential biomarkers were found earlier than clinical symptom and significant pathological changes that may provide important clues for the early detection of these diseases. We think urine proteome has a broad application prospect in the early diagnosis, treatment, monitoring, and prognosis of digestive diseases.

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Acknowledgments

This chapter is based on published articles:

1.
Zhang F, Ni Y, Yuan Y, Yin W, Gao Y. Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model. Science China Life Sciences. 2018; 61(11):1369–1381.
2.
Zhang L, Li Y, Gao Y. Early changes in the urine proteome in a diethyldithiocarbamate-induced chronic pancreatitis rat model. J Proteomics. 2018;186:8–14.
3.
Qin W, Li L, Wang T, Huang H, Gao Y. Urine proteome changes in a TNBS-induced colitis rat model. Proteomics Clin Appl. 2019; e1800100. https://doi.org/10.1002/prca.201800100.

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Authors and Affiliations

School of Life Sciences, Beijing Normal University, Beijing, China
Linpei Zhang
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Fanshuang Zhang
Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China
Weiwei Qin

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Linpei Zhang
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Fanshuang Zhang
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Weiwei Qin
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College of Life Sciences, Beijing Normal University, Beijing, Beijing, China
Youhe Gao

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Zhang, L., Zhang, F., Qin, W. (2019). The Application of Urinary Proteomics in Early Detection of Digestive Diseases. In: Gao, Y. (eds) Urine. Springer, Singapore. https://doi.org/10.1007/978-981-13-9109-5_16

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DOI: https://doi.org/10.1007/978-981-13-9109-5_16
Published: 17 September 2019
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-9108-8
Online ISBN: 978-981-13-9109-5
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