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The Biosynthesis and Folding of Oily Peptide Chains

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Advances in Membrane Proteins

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Abstract

A newly synthesized peptide goes through several biosynthetic steps before achieving the right structure to perform the right function. Despite greatly expanded understanding on membrane protein trafficking between organelles, the molecular mechanisms underlying the biogenic steps of membrane proteins, especially the folding pathways, within the endoplasmic reticulum (ER) remain largely unknown. This chapter mainly focuses on the biogenesis of membrane proteins and secreted proteins, and covers current advances in understanding the folding and other biosynthetic steps in the ER and the Golgi apparatus. We also discuss protein misfolding diseases and the pharmacological strategies to rescue the defective biosynthesis of the misfolded proteins.

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  1. Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China

    Kai Li & Shi-Qing Cai

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  1. Department of Orthopaedics and Institute of Precision Medicine, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Yu Cao

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Li, K., Cai, SQ. (2019). The Biosynthesis and Folding of Oily Peptide Chains. In: Cao, Y. (eds) Advances in Membrane Proteins. Springer, Singapore. https://doi.org/10.1007/978-981-13-9077-7_5

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