Abstract
The physiochemical stability of polyphenols is affected by environmental parameters (e.g., light, oxygen, or temperature) and hence their metabolism, stability inside the biological system, bioavailability, and bioactivity are altered. These limitations can be overcome by loading the polyphenols into nanoparticles. An increase in the bioavailability of polyphenol (epigallocatechin gallate, curcumin, and resveratrol) nanoparticles is observed with an enhancement in their solubility, prevention of intestinal environment-mediated degradation, elevation of the permeation rate in small intestine, and enhancement of its pharmacokinetic characters. The bioactivities such as anticancer, antioxidant, antidiabetic, and anti-inflammatory of polyphenols have been reported to be enhanced after nanoparticle encapsulation.
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References
Abdel-Mageid AD et al (2018) The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats. Phytomedicine Int J Phytotherapy Phytopharmacol 43:126–134. https://doi.org/10.1016/j.phymed.2018.04.039. Germany
Abrego G et al (2015) Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration. Eur J Pharm Biopharm 95:261–270. https://doi.org/10.1016/j.ejpb.2015.01.026
Ahangarpour A et al (2018) Solid lipid nanoparticles of Myricitrin have antioxidant and antidiabetic effects on Streptozotocin-nicotinamide-induced diabetic model and Myotube cell of male mouse. Oxid Med Cell Longev 2018:7496936. https://doi.org/10.1155/2018/7496936. Hindawi
Ahmed S et al (2016) Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. J Radiat Res Appl Sci 9(1):1–7. https://doi.org/10.1016/j.jrras.2015.06.006
Akbar MU et al (2018) In-vivo anti-diabetic and wound healing potential of chitosan/alginate/maltodextrin/pluronic-based mixed polymeric micelles: curcumin therapeutic potential. Int J Biol Macromol 120:2418–2430. https://doi.org/10.1016/j.ijbiomac.2018.09.010
Anand P et al (2008) Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Lett 267(1):133–164. https://doi.org/10.1016/j.canlet.2008.03.025
Castangia I et al (2014) Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. Acta Biomater 10(3):1292–1300. https://doi.org/10.1016/j.actbio.2013.11.005. England
Chang C-Y et al (2016) Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization. Int J Nanomed 12:279–294. https://doi.org/10.2147/IJN.S114754. Dove Medical Press
Chauhan AS (2018) Dendrimers for drug delivery. Molecules 23(4). https://doi.org/10.3390/molecules23040938
Daisy P, Saipriya K (2012) Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. Int J Nanomed 7:1189–1202. https://doi.org/10.2147/IJN.S26650. 2012/03/07. Dove Medical Press
Devadasu VR, Wadsworth RM, Kumar MNVR (2011) Protective effects of nanoparticulate coenzyme Q10 and curcumin on inflammatory markers and lipid metabolism in streptozotocin-induced diabetic rats: a possible remedy to diabetic complications. Drug Deli Trans Res 1(6):448–455. https://doi.org/10.1007/s13346-011-0041-3. United States
Dora CL et al (2016) Oral delivery of a high quercetin payload Nanosized emulsion: in vitro and in vivo activity against B16-F10 melanoma. J Nanosci Nanotechnol 16(2):1275–1281. United States
Dube A, Nicolazzo JA, Larson I (2011) Chitosan nanoparticles enhance the plasma exposure of (−)-epigallocatechin gallate in mice through an enhancement in intestinal stability. Eur J Pharm Sci 44(3):422–426. https://doi.org/10.1016/j.ejps.2011.09.004
Fangueiro JF et al (2015) Current nanotechnology approaches for the treatment and management of diabetic retinopathy. Eur J Pharm Biopharm 95:307–322. https://doi.org/10.1016/j.ejpb.2014.12.023
Fangueiro JF et al (2016) Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): in vivo, in vitro and ex vivo studies. Int J Pharm 502(1–2):161–169. https://doi.org/10.1016/j.ijpharm.2016.02.039. Elsevier BV
Gadkari PV, Balaraman M (2015) Extraction of catechins from decaffeinated green tea for development of nanoemulsion using palm oil and sunflower oil based lipid carrier systems. J Food Eng 147:14–23. https://doi.org/10.1016/j.jfoodeng.2014.09.027
Gokce EH et al (2012) Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomed 7:1841–1850. https://doi.org/10.2147/IJN.S29710. 2012/04/11. Dove Medical Press
Grama CN et al (2013) Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLoS One 8(10):e78217. https://doi.org/10.1371/journal.pone.0078217
Granja A et al (2017) Folate-targeted nanostructured lipid carriers for enhanced oral delivery of epigallocatechin-3-gallate. Food Chem 237:803–810. https://doi.org/10.1016/j.foodchem.2017.06.019
Gunatillake PA, Adhikari R (2003) Biodegradable synthetic polymers for tissue engineering. Eur Cells Mater 5:1–16. discussion 16. Switzerland
Guo C et al (2016) Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Sci Rep 6:29753. https://doi.org/10.1038/srep29753
Gupta P et al (2015) Quercetin conjugated poly(beta-amino esters) nanogels for the treatment of cellular oxidative stress. Acta Biomater 27:194–204. https://doi.org/10.1016/j.actbio.2015.08.039. England
Han J et al (2016) Peptide micelle-mediated curcumin delivery for protection of islet beta-cells under hypoxia. J Drug Target 24(7):618–623. https://doi.org/10.3109/1061186X.2015.1132220. England
Harada T, Lincoln SF, Kee TW (2016) Excited-state dynamics of the medicinal pigment curcumin in a hydrogel. Phys Chem Chem Phys PCCP 18(40):28125–28133. https://doi.org/10.1039/c6cp05648b. England
Hong Z et al (2014) Improving the effectiveness of (−)-epigallocatechin Gallate (EGCG) against rabbit atherosclerosis by EGCG-loaded nanoparticles prepared from chitosan and Polyaspartic acid. J Agri Food Chem 62(52):12603–12609. https://doi.org/10.1021/jf504603n. American Chemical Society
Jia T et al (2017) Nanoparticle-encapsulated curcumin inhibits diabetic neuropathic pain involving the P2Y12 receptor in the dorsal root ganglia. Front Neurosci 11:755. https://doi.org/10.3389/fnins.2017.00755. Switzerland
Joshi RP et al (2013) SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection. Nanomed Nanotechnol Biol Med 9(6):776–785. https://doi.org/10.1016/j.nano.2013.01.001. United States
Kamar SS, Abdel-Kader DH, Rashed LA (2018) Beneficial effect of curcumin nanoparticles-hydrogel on excisional skin wound healing in type-I diabetic rat: histological and immunohistochemical studies. Ann Anat Anatomischer Anzeiger: Off Organ Anatomische Gesellschaft 222:94–102. https://doi.org/10.1016/j.aanat.2018.11.005. Germany
Karri VVSR et al (2016) Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing. Int J Biol Macromol 93:1519–1529. https://doi.org/10.1016/j.ijbiomac.2016.05.038
Katas H et al (2017) Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: synthesis and drug release. Ther Deliv 8(3):137–150. https://doi.org/10.4155/tde-2016-0075
Kluin OS et al (2013) Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert Opin Drug Deliv 10(3):341–351. https://doi.org/10.1517/17425247.2013.751371. England
Lee M-J et al (2002) Pharmacokinetics of tea catechins after ingestion of green tea and (−)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomark Prev 11(10):1025–1032
Lin Y-H, Lin J-H, Hong Y-S (2017) Development of chitosan/poly-gamma-glutamic acid/pluronic/curcumin nanoparticles in chitosan dressings for wound regeneration. J Biomed Mater Res Part B Appl Biomater 105(1):81–90. https://doi.org/10.1002/jbm.b.33394. United States
Liu J et al (2018) Encapsulation of curcumin nanoparticles with MMP9-responsive and thermos-sensitive hydrogel improves diabetic wound healing. ACS Appl Mat Interfaces 10(19):16315–16326. https://doi.org/10.1021/acsami.8b03868. United States
Montenegro L et al (2017) Resveratrol-loaded lipid Nanocarriers: correlation between in vitro occlusion factor and in vivo skin hydrating effect. Pharmaceutics 9(4):58. https://doi.org/10.3390/pharmaceutics9040058. MDPI
Moradi A et al (2018) An improvement in acute wound healing in mice by the combined application of photobiomodulation and curcumin-loaded iron particles. Lasers Med Sci 34:779. https://doi.org/10.1007/s10103-018-2664-9. England
Neves AR et al (2013) Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. Int J Nanomedicine 8:177–187. https://doi.org/10.2147/IJN.S37840
Pandita D et al (2014) Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol. Food Res Int 62:1165–1174. https://doi.org/10.1016/j.foodres.2014.05.059
Panwar R et al (2018) In-vivo sustained release of nanoencapsulated ferulic acid and its impact in induced diabetes. Mater Sci Eng C 92:381–392. https://doi.org/10.1016/j.msec.2018.06.055
Peñalva R et al (2018) Increased oral bioavailability of resveratrol by its encapsulation in casein nanoparticles. Int J Mol Sci 19(9):2816. https://doi.org/10.3390/ijms19092816. MDPI
Price NL et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15(5):675–690. https://doi.org/10.1016/j.cmet.2012.04.003
Rahimi HR et al (2016) Novel delivery system for natural products: Nano-curcumin formulations. Avicenna J Phytomedicine 6(4):383–398. https://doi.org/10.1016/S0014-5793(03)01265-1
Ramalingam P, Ko YT (2016) Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles. Colloids Surf B: Biointerfaces 139:52–61. https://doi.org/10.1016/j.colsurfb.2015.11.050
Rashidinejad A et al (2014) Delivery of green tea catechin and epigallocatechin gallate in liposomes incorporated into low-fat hard cheese. Food Chem 156:176–183. https://doi.org/10.1016/j.foodchem.2014.01.115
Serini S et al (2018) Omega-3 PUFA loaded in resveratrol-based solid lipid nanoparticles: physicochemical properties and antineoplastic activities in human colorectal Cancer cells in vitro. Int J Mol Sci 19(2):586. https://doi.org/10.3390/ijms19020586. MDPI
Sheny DS, Mathew J, Philip D (2011) Phytosynthesis of au, ag and au–ag bimetallic nanoparticles using aqueous extract and dried leaf of Anacardium occidentale. Spectrochim Acta A Mol Biomol Spectrosc 79(1):254–262. https://doi.org/10.1016/j.saa.2011.02.051
Shoba G et al (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64(4):353–356. https://doi.org/10.1055/s-2006-957450. Germany
Singh G, Pai RS (2014) Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Expert Opin Drug Deliv 11(5):647–659. https://doi.org/10.1517/17425247.2014.890588. England
Siu FYK, Ye S, Lin H, Li S (2018) Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity. Int J Nanomedicine 13:4133–4144
Soleas GJ et al (2001) Absorption of trans-resveratrol in rats. Methods Enzymol 335:145–154. https://doi.org/10.1016/S0076-6879(01)35239-4
Swarnalatha L, Christina R, Shruti R, Payas B (2012) Evaluation of invitro antidiabetic activity of Sphaeranthus amaranthoides silver nanoparticles. Int J Nanomater Biostruct 2:25–29
Szkudelski T, Szkudelska K (2015) Resveratrol and diabetes: from animal to human studies. Biochim Biophys Acta (BBA) Mol Basis Dis 1852(6):1145–1154. https://doi.org/10.1016/j.bbadis.2014.10.013
Venkatasubbu GD, Anusuya T (2017) Investigation on curcumin nanocomposite for wound dressing. Int J Biol Macromol 98:366–378. https://doi.org/10.1016/j.ijbiomac.2017.02.002
Vijayakumar V et al (2019) Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management. Int J Biol Macromol 122:137–148. https://doi.org/10.1016/j.ijbiomac.2018.10.120
Walle T et al (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32(12):1377 LP–1371382. https://doi.org/10.1124/dmd.104.000885
Yekollu SK, Thomas R, O’Sullivan B (2011) Targeting curcusomes to inflammatory dendritic cells inhibits NF-κB and improves insulin resistance in obese mice. Diabetes. 2011/10/17. American Diabetes Association 60(11):2928–2938. https://doi.org/10.2337/db11-0275
Yücel Ç, Şeker Karatoprak G, Atmar A (2018) Novel resveratrol-loaded Nanocochleates and effectiveness in the treatment of diabetes. Fabad J Pharm Sci
Zhang S et al (2017) Rapid identification of α-glucosidase inhibitors from Dioscorea opposita Thunb peel extract by enzyme functionalized Fe3O4 magnetic nanoparticles coupled with HPLC-MS/MS. Food Funct 8:3219. https://doi.org/10.1039/C7FO00928C
Zu Y et al (2018) Resveratrol liposomes and lipid nanocarriers: comparison of characteristics and inducing browning of white adipocytes. Colloids Surf B Biointerfaces 164:414–423. https://doi.org/10.1016/j.colsurfb.2017.12.044. 2017/12/27
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Hoda, M., Hemaiswarya, S., Doble, M. (2019). Polyphenol Nanoformulations with Potential Antidiabetic Properties. In: Role of Phenolic Phytochemicals in Diabetes Management. Springer, Singapore. https://doi.org/10.1007/978-981-13-8997-9_6
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