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Modulation of Oxidative Stress in Heart Disease pp 81–105Cite as

Myocardial Oxidative Stress and Metabolic Diseases

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Abstract

Aging, diabetes, obesity, atherosclerosis, hypertension, and dyslipidemia shared similar manifestations of cardiomyopathy. This disease is characterized by pathological, cytological, and molecular alterations of both cardiomyocytes and endothelial cells. The disease altered the cytoplasmic organelle structure and function such as mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. These involved dramatic changes of protein synthesis in endoplasmic reticulum, calcium storage in mitochondria, autophagy in lysosomes, and lipid metabolism in Golgi complex. Enhanced lipid peroxidation, oxidative stress, and release of free oxygen species are the main contributing factors of cell damage and cell death. This review summarized the concept of oxidative stress in cardiomyocytes and role of each cytoplasmic organelle in its development during progress of the disease.

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Authors and Affiliations

  1. Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt

    Hassan I. H. El-Sayyad

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  1. Hassan I. H. El-Sayyad
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Correspondence to Hassan I. H. El-Sayyad .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Science, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada

    Naranjan S. Dhalla

  3. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Madhu Dikshit

  4. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Nirmal K. Ganguly

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El-Sayyad, H.I.H. (2019). Myocardial Oxidative Stress and Metabolic Diseases. In: Chakraborti, S., Dhalla, N., Dikshit, M., Ganguly, N. (eds) Modulation of Oxidative Stress in Heart Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-8946-7_4

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