Lipid Metabolism Disorder and Renal Fibrosis

  • Xiao-Gang Du
  • Xiong-Zhong RuanEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1165)


Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this chapter, we will discuss the general promises of the original hypothesis, focusing especially on the role of lipids and metabolic inflammation accompanying CKD in renal fibrosis and potential new strategies of prevention.


Lipids Inflammation Glomerular atherosclerosis Tubulo-interstitial diseases Statin 



“Lipid Nephrotoxicity: New Concept for an Old Disease” was reported by our group in Dyslipidemias in Kidney Disease (Ruan et al. 2014). The related contents are reused with permission.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of NephrologyThe First Affiliated Hospital of Chongqing Medical University of Medical ScienceChongqingChina

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