New Understanding on the Role of Proteinuria in Progression of Chronic Kidney Disease
Proteinuria is identified as an important marker and risk factor of progression in chronic kidney disease. However, the precise mechanism of action in the progress of chronic kidney disease is still unclear. Mesangial toxicity from specific filtered compounds such as albumin-bound fatty acids and transferrin/iron, tubular overload and hyperplasia, and induction of proinflammatory molecules such as MCP-1 and inflammatory cytokines are some of the proposed mechanisms. Reversing intraglomerular hypertension with protein restriction or antihypertensive therapy may be beneficial both by diminishing hemodynamic injury to the glomeruli and by reducing protein filtration. Therefore, understanding proteinuria and its role in renal tubular interstitial inflammation and fibrosis is of great significance for the study of renal protective therapy, such as antiproteinuric treatments, and delaying the progression of chronic renal disease.
KeywordsProteinuria Chronic kidney disease End-stage renal disease
This study was supported by grants from the National Key Research and Development Program of China (2018YFC1314004), the National Natural Science Foundation of China (No. 81720108007, 81670696, 81470922, 81600513 and 31671194), the Clinic Research Center of Jiangsu Province (No. BL2014080), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. KYCX18_0171).
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