Role of Extracellular Vesicles in Renal Inflammation and Fibrosis
Extracellular vesicles (EVs) are the membrane-surrounded structures released by almost all types of cells. Accumulating evidences have suggested that EVs secretion is enhanced under stress conditions and have been associated with a large wide of cellular physiological and pathological processes. In this part, recent understanding about the generation and biological function of EVs was reviewed. Moreover, the role of EVs in renal inflammation and fibrosis and future challenges of EVs study in kidney disease were discussed.
KeywordsExtracellular vesicles Renal fibrosis Renal inflammation Biomarker
This chapter was modified from a paper reported by our group in J Cell Mol Med (Lv et al. 2019).
- Gupta KH, Goldufsky JW, Wood SJ, Tardi NJ, Moorthy GS, Gilbert DZ (2017) Apoptosis and compensatory proliferation signaling are coupled by CrkI-containing microvesicles. Dev Cell 41(674–684):e5Google Scholar
- Lotvall J, Hill AF, Hochberg F, Buzas EI, Di Vizio D, Gardiner C et al (2014) Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 3:26913CrossRefGoogle Scholar
- Park JE, Dutta B, Tse SW, Gupta N, Tan CF, Low JK (2019) Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift. OncogeneGoogle Scholar
- Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R et al (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 7:1535750CrossRefGoogle Scholar
- Vagner T, Spinelli C (2018) Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma 7:1505403Google Scholar