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Chitinous Scaffolds from Marine Sponges for Tissue Engineering

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Marine-Derived Biomaterials for Tissue Engineering Applications

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 14))

Abstract

Chitin as a biological material which has been identified in skeletal structures of a broad variety of unicellular (yeast, protists, diatoms) and multicellular (sponges, corals, worms, molluscs, arthropods) organisms is recognized as natural template with good perspectives in modern biomedicine. This chapter provides first insights into prospective applications of naturally prefabricated three-dimensional chitinous scaffolds from selected marine sponges in tissue engineering. This became possible only owing to the recent discovery of poriferan chitin which provoked renewed multidisciplinary interest driven by growing demand in novel biomimetic materials. Here, we focused on both demosponges of Verongiida order as a renewable source of chitin scaffolds with jewelry designs, and human mesenchymal stromal cells having high therapeutic potential. The chapter covers approaches for isolation of scaffolds from the chitin-bearing marine sponges, nuances of their interaction with human cells and cryopreservation potential.

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Acknowledgements

The present work was partially supported by Leonhard-Euler-Programm from the German Academic Exchange Service (DAAD, Germany), the German Research Foundation through the Cluster of Excellence REBIRTH (EXC 62/1), IP@Leibniz program of the Leibniz University Hannover promoted by the DAAD (Germany, project code 57156199) as well as DFG Grant EH 394-3 (DFG, Germany).

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Authors and Affiliations

  1. Institute for Multiphase Processes, Leibniz University Hannover, Callinstrasse 36, 30167, Hannover, Germany

    Vitalii Mutsenko, Oleksandr Gryshkov & Birgit Glasmacher

  2. Department of Biochemistry, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, 23 Pereyaslavsky Street, Kharkiv, 6101, Ukraine

    Olena Rogulska & Alexander Yu. Petrenko

  3. Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Dresden and the Medical Faculty Carl Gustav Carus of Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany

    Anja Lode & Michael Gelinsky

  4. Biomineralogy and Extreme Biomimetics, Institute of Electronic and Sensor Materials, TU Bergakademie Freiberg, Gustav-Zeuner Str. 3, 09599, Freiberg, Germany

    Hermann Ehrlich

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  1. Vitalii Mutsenko
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  2. Oleksandr Gryshkov
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  3. Olena Rogulska
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  5. Alexander Yu. Petrenko
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Correspondence to Vitalii Mutsenko .

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Editors and Affiliations

  1. School of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, NSW, Australia

    Andy H. Choi

  2. Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia

    Besim Ben-Nissan

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Mutsenko, V. et al. (2019). Chitinous Scaffolds from Marine Sponges for Tissue Engineering. In: Choi, A., Ben-Nissan, B. (eds) Marine-Derived Biomaterials for Tissue Engineering Applications. Springer Series in Biomaterials Science and Engineering, vol 14. Springer, Singapore. https://doi.org/10.1007/978-981-13-8855-2_13

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