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Oxidative Stress in Microbial Diseases pp 329–343Cite as

Oxidative Stress and Antioxidant Supplementation on Immunity in Hansen’s Disease (Leprosy)

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Abstract

Hanseniasis comprises one of the main causes of physical disabilities due to its potential to strike neural lesions, foot deformities, amputations, and mutilations. Since innate response is important in hanseniasis, this work reviewed and updated the role of reactive oxygen/nitrogen species in different clinical forms of hanseniasis, as well as their role in different phagocyte free radicals’ generator systems (NADPH-oxidase, mitochondrial pathways, myeloperoxidase, extracellular traps, iNOS). Since hanseniasis can induce antioxidant depletion, possible benefits of antioxidant nutritional supplementation are also discussed.

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  1. Instituto de Ciências Biológicas e da Saúde (ICBS), Campus Universitário do Araguaia, Universidade Federal de Mato Grosso (UFMT), Barra do Garças, MT, Brazil

    Carlos Kusano Bucalen Ferrari

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Amity University, Kolkata, West Bengal, India

    Dhrubajyoti Chattopadhyay

  4. National Institute of Immunology, New Delhi, India

    Chandrima Shaha

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Ferrari, C.K.B. (2019). Oxidative Stress and Antioxidant Supplementation on Immunity in Hansen’s Disease (Leprosy). In: Chakraborti, S., Chakraborti, T., Chattopadhyay, D., Shaha, C. (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8763-0_18

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