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The Advances of Nanozyme in Brain Disease

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Book cover Nanomedicine in Brain Diseases

Abstract

Reactive oxygen species (ROS), a class of metabolites produced in biological aerobic metabolism, play a key role in conducting cellular signals and maintaining normal nerve functions in central nerve system. However, under some pathological conditions, oxidative stress caused by excessive ROS may become an important factor in the occurrence and deterioration of neurological disease. Therefore, it is crucial to control the level of ROS in the central nervous system in time. Traditional ROS regulators, such as some natural enzymes and assemblies based on them, have not been well applied in brain diseases due to their instability and limited ability to cross the blood–brain barrier (BBB). Nanozymes, stable inorganic nanomaterials that possess intrinsic enzyme-mimic activities, have attracted wide attention in the scientific community in recent years attributed to their efficient ability to alleviate oxidative stress in the central nervous system. This chapter reviews the advances in the application of nanozymes in the treatment of neurological diseases and discusses the challenges and perspectives of nanozymes for their clinical translations. We hope that this chapter will arouse readers’ interest in nanozymes and promote the research and application of nanozymes in brain diseases.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (No. 31530026, 31871005, 31900981), Chinese Academy of Sciences under Grant No. YJKYYQ20180048, Youth Innovation Promotion Association CAS (2019093), Strategic Priority Research Program (No. XDB29040101), Key Research Program of Frontier Sciences (No. QYZDY-SSW-SMC013), Chinese Academy of Sciences, National Key Research and Development Program of China (No. 2017YFA0205501).

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  1. CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Ruofei Zhang, Xiyun Yan & Kelong Fan

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  1. Ruofei Zhang
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  2. Xiyun Yan
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  3. Kelong Fan
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Correspondence to Xiyun Yan or Kelong Fan .

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  1. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, Tianjin, China

    Xue Xue

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Zhang, R., Yan, X., Fan, K. (2019). The Advances of Nanozyme in Brain Disease. In: Xue, X. (eds) Nanomedicine in Brain Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8731-9_6

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