Skip to main content

Myelinated Retinal Fiber Layer

  • Chapter
  • First Online:
Trauma and Miscellaneous Disorders in Retina

Part of the book series: Retina Atlas ((RA))

  • 419 Accesses

Abstract

Myelinated retinal nerve fiber (MRNF) layers are a relatively common ophthalmoscopic finding and were first described as “chalk-white spots” by Virchow in 1856 (2). It appears in 0.57–1% of the population, typically present at birth as static lesions, and can occur bilaterally in 7.7% of affected patients (Gradle 1921; Virchow 1856).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aaby AA, Kushner BJ. Acquired and progressive myelinated nerve fibers. Arch Ophthalmol. 1985;103:542–4.

    Article  CAS  Google Scholar 

  • Ali BH, Logani S, Kozlov KL, Arnold AC, Bateman B. Progression of retinal nerve fiber myelination in childhood. Am J Ophthalmol. 1994;118:515–7.

    Article  CAS  Google Scholar 

  • Baarsma GS. Acquired medullated nerve fibres. Br J Ophthalmol. 1980;64(9):651.

    Article  CAS  Google Scholar 

  • Bozkurt B, Yildirim MS, Okka M, Bitirgen G. GAPO syndrome: four new patients with congenital glaucoma and myelinated retinal nerve fiber layer. Am J Med Genet A. 2013;161(4):829–34.

    Article  Google Scholar 

  • De Jong PT, Bistervels B, Cosgrove J, de Grip G, Leys A, Goffin M. Medullated nerve fibers. A sign of multiple basal cell nevi (Gorlin’s) syndrome. Arch Ophthalmol. 1985;103(12):1833–6.

    Article  Google Scholar 

  • Duke-Elder S. Congenital deformities. In: Duke-Elder S, editor. System of ophthalmology. St Louis: CV Mosby; 1963. p. 646–51.

    Google Scholar 

  • FitzGibbon T, Nestorovski Z. Morphological consequences of myelination in the human retina. Exp Eye Res. 1997;65(6):809–19.

    Article  CAS  Google Scholar 

  • Gradle HS. The blind spot: III. The relation of the blind spot to medullated nerve fibers in the retina. J Am Med Assoc. 1921;77(19):1483–7.

    Article  Google Scholar 

  • Jean-Louis G, Katz BJ, Digre KB, Warner JEA, Creger DD. Acquired and progressive retinal nerve fiber layer myelination in an adolescent. Am J Ophthalmol. 2000;130(3):361–2.

    Article  CAS  Google Scholar 

  • Kodama T, Hayasaka S, Setogawa T. Myelinated retinal nerve fibers: prevalence, location and effect on visual acuity. Ophthalmologica. 1990;200(2):77–83.

    Article  CAS  Google Scholar 

  • Kushner BJ. Optic nerve decompression. Arch Ophthalmol. 1979;97:1459–61.

    Article  CAS  Google Scholar 

  • Magoon EH, Robb RM. Development of myelin in human optic nerve and tract: a light and electron microscopic study. Arch Ophthalmol. 1981;99(4):655–9.

    Article  CAS  Google Scholar 

  • Parulekar MV, Elston JS. Acquired retinal myelination in neurofibromatosis 1. Arch Ophthalmol. 2002;120(5):659–5.

    PubMed  Google Scholar 

  • Shelton JB, Digre KB, Gilman J, Warner JEA, Katz BJ. Characteristics of myelinated retinal nerve fiber layer in ophthalmic imaging: findings on autofluorescence, fluorescein angiographic, infrared, optical coherence tomographic, and red-free images. JAMA Ophthalmol. 2013;131(1):107–9.

    Article  Google Scholar 

  • Straatsma BR, Foos RY, Heckenlively JR, Taylor GN. Myelinated retinal nerve fibers. Am J Ophthalmol. 1981;91(1):25–38.

    Article  CAS  Google Scholar 

  • Tarabishy AB, Alexandrou TJ, Traboulsi EI. Syndrome of myelinated retinal nerve fibers, myopia, and amblyopia: a review. Surv Ophthalmol. 2007;52(6):588–96.

    Article  Google Scholar 

  • Virchow VR. Zur pathologischen anatomic der netzaut und des scherven. Virchows Arch Pathol Anat. 1856;10:170–93.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

de Queiroz Alves, B. (2020). Myelinated Retinal Fiber Layer. In: Rodrigues, E., Meyer, C., Tomazoni, E. (eds) Trauma and Miscellaneous Disorders in Retina. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-13-8550-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-8550-6_15

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-8549-0

  • Online ISBN: 978-981-13-8550-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics