Optic Disc Drusen
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Optic disc drusen (ODD) are acellular bodies of hyaline deposits located both intracellularly and extracellularly first described by Muller in 1858 (Muller 1858; Hamann et al. 2018). The main clinical significance of optic disc drusen is that they can simulate true optic disc edema. Misdiagnosing drusen as true disc edema may lead to an extensive, invasive, and unnecessary systemic work-up, including neuroimaging and lumbar puncture. An ODD prevalence of 2.4% has been found in autopsy studies, though it has been reported to be significantly lower using in vivo imaging modalities. The prevalence of ODD is higher in women and involvement is usually bilateral (Lorentzen 1966; Friedman et al. 1975).
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