Abstract
Nystagmus can be a physiological response or the sign of a serious underlying disease. It is an extremely complex spectrum of motility abnormalities, and both experience and skill are needed to decipher it completely. This chapter introduces the reader to the various forms of nystagmus, beginning with physiological nystagmus. Congenital nystagmus and its various forms are described in detail—the newer nomenclature for this entity has also been included. Acquired varieties of nystagmus such as downbeat and upbeat nystagmus and vestibular nystagmus are discussed along with other more rare variants such as see-saw nystagmus. Other related motility abnormalities such as opsoclonus, flutter, saccadic intrusions, and square-wave jerks are also explained. A brief account of the clinical examination including pertinent tests is described. Management of nystagmus has also been included.
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References
Sarvananthan N, Surendran M, Roberts EO, Jain S, Thomas S, Shah N, et al. The prevalence of nystagmus: the Leicestershire nystagmus survey. Invest Ophthalmol Vis Sci. 2009;50(11):5201–6.
Spielmann A. Clinical rationale for manifest congenital nystagmus surgery. J AAPOS. 2000;4(2):67–74.
Abadi RV, Bjerre A. Motor and sensory characteristics of infantile nystagmus. Br J Ophthalmol. 2002;86:1152–60.
Leigh RJ, Rucker JC. Nystagmus and related ocular motility disorders. In: Miller NR, Newman NJ, editors. Walsh & Hoyt’s clinical neuro-ophthalmology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 1133–73.
Brodsky MC, et al. Nystagmus in infancy and childhood. In: Brodsky MC, Baker RS, Hamed LM, editors. Pediatric neuroophthalmology. New York: Springer; 1996. p. 302–47.
Von Noorden GK. The nystagmus blockage syndrome. Trans Am Ophthalmol Soc. 1976;74:220–36.
Tychsen L, et al. The neural mechanism for latent (fusion maldevelopment) nystagmus. J Neuroophthalmol. 2010;30:276–83.
Thurtell MJ, Leigh RJ. Nystagmus and saccadic intrusions. Handb Clin Neurol. 2011;102:333–78.
Wagner JN, Glaser M, Brandt T, Strupp M. Downbeat nystagmus: aetiology and comorbidity in 117 patients. J Neurol Neurosurg Psychiatry. 2008;79(6):672–7.
Claassen J, Spiegel R, Kalla R, et al. A randomized double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus V effects on slowphase eye velocity, postural stability, locomotion and symptoms. J Neurol Neurosurg Psychiatry. 2013;84(12):1392–9.
Claassen J, Feil K, Bardins S, et al. Dalfampridine in patients with downbeat nystagmus V an observational study. J Neurol. 2013;260(8):1992–6.
Thurtell MJ, Leigh RJ. Therapy for nystagmus. J Neuroophthalmol. 2010;30(4):361–71.
Thurtell MJ, Joshi AC, Leone AC, et al. Crossover trial of gabapentin and memantine as treatment for acquired nystagmus. Ann Neurol. 2010;67(5):676–80.
Glasauer S, Kalla R, Buttner U, et al. 4-aminopyridine restores visual ocular motor function in upbeat nystagmus. J Neurol Neurosurg Psychiatry. 2005;76(3):451–3.
Dieterich M, Straube A, Brandt T, et al. The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. J Neurol Neurosurg Psychiatry. 1991;54(7):627–32.
Baloh RW, Honrubia V, Konrad HR. Periodic alternating nystagmus. Brain. 1976;99(1):11–26.
Leigh RJ, Robinson DA, Zee DS. A hypothetical explanation for periodic alternating nystagmus: instability in the optokinetic-vestibular system. Ann N Y Acad Sci. 1981;374:619–35.
Serra A, Liao K, Martinez-Conde S, et al. Suppression of saccadic intrusions in hereditary ataxia by memantine. Neurology. 2008;70(10):810–2.
Thurtell MJ, Rucker JC, Tomsak RL, Leigh RJ. Medical treatment of acquired nystagmus. Expert Rev Ophthalmol. 2011;6:307–14.
Hertle RW, Yang D, Adkinson T, et al. Topical brinzolamide (Azopt) versus placebo in the treatment of infantile nystagmus syndrome (INS). Br J Ophthalmol. 2015;99:471–6.
Dell’osso LF, et al. Effects of topical brinzolamide on infantile nystagmus syndrome waveforms: eyedrops for nystagmus. J Neuroophthalmol. 2011;31(3):228–33.
Hertle RW. Examination and refractive management of patients with nystagmus. Surv Ophthalmol. 2000;45:215–22.
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Shetty, S., Sood, A. (2020). Nystagmus. In: Chhablani, P. (eds) Neuro-ophthalmic Disorders. Current Practices in Ophthalmology. Springer, Singapore. https://doi.org/10.1007/978-981-13-8522-3_6
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DOI: https://doi.org/10.1007/978-981-13-8522-3_6
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