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Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study Using Intratracheal Administration

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In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

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Abstract

The toxicity of nanomaterials is complex and multifactorial and likely depends on their diverse physicochemical properties. Further development and application of nanomaterials requires a systematic, effective, and efficient method for evaluating their toxicity. One approach in this regard is to ascertain the variability in the physicochemical properties of nanomaterials that exhibit the same toxicity—that is, to establish “equivalence criteria” for nanomaterials. However, this approach requires the acquisition and comparison of toxicity data for various nanomaterials. In this chapter, we summarize our efforts to establish equivalence criteria for nanomaterials in regard to their toxicity after intratracheal instillation. To achieve this objective, we focused on intratracheal administration studies for evaluating nanomaterial toxicity simply and efficiently. Intratracheal instillation offers various advantages and disadvantages compared with inhalation exposure, which is widely used as a screening tool. In this study, we used intratracheal instillation to deliver a total of 20 nanomaterials representing three types (TiO2, NiO, and SiO2) to rats. We then compared the physicochemical properties and pulmonary toxicities of the tested nanomaterials and thus were able to detect characteristic features of their pulmonary toxic effects according to their physicochemical properties. We here demonstrated the effectiveness of using intratracheal administration studies to screen for pulmonary toxicity of nanomaterials. In addition, we anticipate that our proposed equivalence criteria will facilitate toxicity evaluation of nanomaterials.

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Acknowledgements

This work is part of the research program “Development of innovative methodology for safety assessment of industrial nanomaterials” supported by the Ministry of Economy, Trade and Industry (METI) of Japan.

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Authors and Affiliations

  1. Chemicals Evaluation and Research Institute, Japan, CERI Hita, Hita-shi, Oita, Japan

    Yutaka Oshima, Toshio Kobayashi & Makoto Nakai

  2. Chemicals Evaluation and Research Institute, Japan, Headquarters, Tokyo, Japan

    Takakazu Kayashima & Nobuya Imatanaka

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  1. Yutaka Oshima
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  2. Toshio Kobayashi
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  3. Takakazu Kayashima
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  4. Makoto Nakai
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  5. Nobuya Imatanaka
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Correspondence to Yutaka Oshima .

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Editors and Affiliations

  1. Graduate School of Health Management, Keio University, Fujisawa, Kanagawa, Japan

    Toru Takebayashi

  2. Experimental Toxicology and Ecology, BASF SE, Ludwigshafen am Rhein, Germany

    Robert Landsiedel

  3. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Masashi Gamo

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Oshima, Y., Kobayashi, T., Kayashima, T., Nakai, M., Imatanaka, N. (2019). Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study Using Intratracheal Administration. In: Takebayashi, T., Landsiedel, R., Gamo, M. (eds) In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-8433-2_9

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  • DOI: https://doi.org/10.1007/978-981-13-8433-2_9

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