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In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials pp 67–77Cite as

Use of Short-Term Inhalation Study to Obtain Initial Hazard Data and Prepare for Subacute and Subchronic Inhalation Studies, and Toxicokinetic Studies

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Abstract

A short-term inhalation study (STIS) protocol that has been specifically developed for testing nanomaterials can be used as an alternative testing choice for acute toxicity testing, and a range-finding study for subacute and subchronic studies. The STIS can also be used to characterize the nanoparticle physicochemical properties and determine the type of exposure and particle monitoring methods in the inhalation chamber for subsequent subacute and subchronic inhalation studies. In addition, importantly, the particle generation method and particle concentration stability can be studied before and during the STIS. Furthermore, combining an STIS with a lung burden analysis, which is now a mandatory requirement for OECD 412 (subacute) and 413 (subchronic) test guidelines, can provide toxicokinetic information, including the biodistribution and lung clearance of nanoparticles.

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Acknowledgement

This research was supported by the Industrial Technology Innovation Program (10052901), Development of highly usable nanomaterial inhalation toxicity testing system in commerce through the Korea Evaluation Institute of Industrial Technology by the Korean Ministry of Trade, Industry & Energy

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Authors and Affiliations

  1. HCTm Co. Ltd., Icheon, Republic of Korea

    Ki Soo Jeon, Jae Seong Yi & Il Je Yu

Authors
  1. Ki Soo Jeon
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  2. Jae Seong Yi
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  3. Il Je Yu
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Correspondence to Il Je Yu .

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Editors and Affiliations

  1. Graduate School of Health Management, Keio University, Fujisawa, Kanagawa, Japan

    Toru Takebayashi

  2. Experimental Toxicology and Ecology, BASF SE, Ludwigshafen am Rhein, Germany

    Robert Landsiedel

  3. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Masashi Gamo

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Jeon, K.S., Yi, J.S., Yu, I.J. (2019). Use of Short-Term Inhalation Study to Obtain Initial Hazard Data and Prepare for Subacute and Subchronic Inhalation Studies, and Toxicokinetic Studies. In: Takebayashi, T., Landsiedel, R., Gamo, M. (eds) In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-8433-2_3

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  • DOI: https://doi.org/10.1007/978-981-13-8433-2_3

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