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Microbial Interventions in Agriculture and Environment pp 381–418Cite as

Microbial Bio-production of Proteins and Valuable Metabolites

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Abstract

Microbes are widely utilized as workhorses for production of numerous valuable metabolites with utility in different sectors including food, energy, environment, agriculture, health, and disease management. Microbes are capable of synthesizing spectrum of structurally divergent compounds, which are even difficult to be prepared by chemical synthesis. Microbes synthesize many metabolites of interest naturally as an intermediate/product of their metabolic pathways, or another approach is redesigning/creating biosynthetic pathways in microbes for production of non-native target metabolite from simple and cheap substrates not only at laboratory scale but also at the industrial scale. Advancements in genetic engineering, genome sequencing, transcriptomics, proteomics, and computational approaches have revolutionized the identification of novel bioactive molecules of microbial origin and redesigning of microbial biosynthetic pathways. The present book chapter focuses primarily on microbial products including enzymes, proteins, chemicals, and secondary metabolites as well as their production strategies, their application in various fields, and development of engineered microbes as production factories.

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Acknowledgement

SK is thankful to the Department of Biotechnology (DBT) (BT/P19588/BIC/101/425/2016) for their financial assistance and National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, for providing the necessary support.

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Authors and Affiliations

  1. Department of Biotechnology, National Institute of Pharmaceutical Education and Research-Guwahati, Guwahati, Assam, India

    Abiya Johnson, Prajkata Deshmukh & Shubhangi Kaushik

  2. Department of Biochemistry, Royal Global University, Guwahati, Assam, India

    Vimal Sharma

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  1. Abiya Johnson
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  2. Prajkata Deshmukh
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  4. Vimal Sharma
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Correspondence to Shubhangi Kaushik .

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  1. Department of Biotechnology, ICAR – NBAIM, Maunath Bhanjan, Uttar Pradesh, India

    Dhananjaya Pratap Singh

  2. Department of Chemistry & Biotechnology, School of Science, Tallinn University of Technology, Tallinn, Estonia

    Vijai Kumar Gupta

  3. Department of Biotechnology, ICAR – NBAIM, Maunath Bhanjan, Uttar Pradesh, India

    Ratna Prabha

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Johnson, A., Deshmukh, P., Kaushik, S., Sharma, V. (2019). Microbial Bio-production of Proteins and Valuable Metabolites. In: Singh, D., Gupta, V., Prabha, R. (eds) Microbial Interventions in Agriculture and Environment. Springer, Singapore. https://doi.org/10.1007/978-981-13-8391-5_15

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