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Oxidative Stress in Heart Diseases pp 191–203Cite as

Oxidative Stress and Modulation of Cardiac Kv1.5 Channel

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Abstract

Oxidative stress is a result of imbalance between cellular oxidants and antioxidants. The oxidants like Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered to induce many pathological processes including heart failure. They target the ion channels for any kind of modifications or mutations that alter the channels' usual function. There are evidences showing oxidative stress to modulate the ion channels and transporters that play crucial role in general physiology of heart, leading to many prevalent cardiovascular disorders including atrial fibrillation (AF). Though the fundamental cause of AF is not still understood, but modulation of Kv1.5 channel has been successfully proved to be one of the strategic therapeutic interventions. In this chapter, the current knowledge on the effects of oxidative stress in heart has been summarized along with the roles of ion channels and their modulation.

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Authors and Affiliations

  1. BIF Centre, Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Rajabrata Bhuyan

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Authors
  1. Rajabrata Bhuyan
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  2. Sajal Chakraborti
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, St Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB, Canada

    Naranjan S Dhalla

  3. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Nirmal K Ganguly

  4. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Madhu Dikshit

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© 2019 Springer Nature Singapore Pte Ltd.

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Bhuyan, R., Chakraborti, S. (2019). Oxidative Stress and Modulation of Cardiac Kv1.5 Channel. In: Chakraborti, S., Dhalla, N., Ganguly, N., Dikshit, M. (eds) Oxidative Stress in Heart Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8273-4_9

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