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Molecular Targets and Novel Therapeutics to Target Oxidative Stress in Cardiovascular Diseases

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Oxidative Stress in Heart Diseases

Abstract

According to WHO, cardiovascular disease burden is significantly increasing worldwide due to an ageing population and spread of the Western diet and lifestyle. Moreover, it is now evident that autophagy influenes the development and progression of various cardiovascular diseases. Interestingly, the regulatory mechanisms of autophagy are primarily activated upon either reactive oxygen species overproduction, or NO deficiency, or nutrient deprivation. Although, RONS and the ensuing oxidative stress are studied in the milieu of impairment of biologically vital targets like DNA, lipids, or proteins, but many antioxidant-based clinical studies have failed to generate a positive result in the context of human disease, particularly CVDs. Along with moderate aerobic exercise, antioxidant therapy such as resveratrol and other phytochemicals, may prevent against the adverse effects of oxidative stress, however, there is a need to obviate or lessen the further tissue damage created by free radicals in later stages of CVD. However, apart from antioxidants, there are several potential candidates that may serve as therapeutic agents to curb oxidative stress in CVDs such as γ-glutamylcysteine supplementation, targeting mitochondria, HSP72 augmentation and curbing ER stress.

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Authors and Affiliations

  1. Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Veena Dhawan & Chetan Bakshi

  2. Department of Biotechnology, Wachemo University, Hossana, Ethiopia

    Riyaz Ahmad Rather

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  1. Veena Dhawan
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  2. Chetan Bakshi
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  3. Riyaz Ahmad Rather
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, St Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB, Canada

    Naranjan S Dhalla

  3. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Nirmal K Ganguly

  4. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Madhu Dikshit

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Dhawan, V., Bakshi, C., Rather, R.A. (2019). Molecular Targets and Novel Therapeutics to Target Oxidative Stress in Cardiovascular Diseases. In: Chakraborti, S., Dhalla, N., Ganguly, N., Dikshit, M. (eds) Oxidative Stress in Heart Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8273-4_4

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