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The Potential Effects of Taurine in Mitigation of Radiation Nephropathy

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Taurine 11

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1155))

Abstract

Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid possessing several important effects, including antioxidant and anti-inflammatory ones. Exposure to ionizing radiation generates free radicals and reactive oxygen species (ROS) in irradiated cells, and free radical generation leads to oxidative stress. It is known that radiation nephropathy includes an inflammation-based process in which ROS and cytokines are responsible. Different doses of explored radiation can cause apoptosis, inflammation and a profound oxidative stress in kidneys. Oxidative stress is involved in renal injury after exposure to both ionizing radiation and inflammation. In this review, we describe the protective effect of taurine against several kidney diseases and the potential effects of taurine in the mitigation of radiation nephropathy. We also report that X-irradiation decreased the expression of taurine and TauT in the kidney. Taurine administration suppressed the decrease in the expression of taurine and TauT in the kidney after radiation exposure. Taurine might contribute to the mitigation of kidney injury induced by radiation.

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Abbreviations

ROS:

reactive oxygen species

Tau:

taurine

TauT:

taurine transporter

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Acknowledgements

We thank Yui Naganuma, Yusuke Hasegawa and Riki Miyabayashi for the handling of the animals and for assistance in the drug administration part of this work. This work was supported by JSPS KAKENHI Grant Number JP 17 K15809 and JP 17H04654.

Author information

Authors and Affiliations

  1. Division of Health Science, Graduate School of Health Science, Suzuka University, Suzuka, Mie, Japan

    Ning Ma

  2. Department of Rehabilitation, Suzuka Kaisei Hospital, Suzuka, Japan

    Toshihiro Kato

  3. Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Japan

    Tamami Isogai & Takenori Yamashita

  4. Faculty of Health Science, Junshin Gakuen University, Fukuoka, Japan

    Yeunhwa Gu

  5. Division of Health Science, Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan

    Takenori Yamashita

Authors
  1. Ning Ma
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  2. Toshihiro Kato
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  3. Tamami Isogai
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  4. Yeunhwa Gu
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  5. Takenori Yamashita
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Corresponding author

Correspondence to Takenori Yamashita .

Editor information

Editors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China

    Jianmin Hu

  2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China

    Fengyuan Piao

  3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Abdeslem El Idrissi

  5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Jang-Yen Wu

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Ma, N., Kato, T., Isogai, T., Gu, Y., Yamashita, T. (2019). The Potential Effects of Taurine in Mitigation of Radiation Nephropathy. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_46

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