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Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model

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Taurine 11

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1155))

Abstract

Taurine content in the body is maintained by both biosynthesis from sulfur-contained amino acids in the liver and ingestion from usual foods, mainly seafoods and meat. Contrary to the rodents, the maintenance of taurine content in the body depends on the oral taurine ingestion in cats as well as humans because of the low ability of the biosynthesis. Therefore, insufficient of dietary taurine intake increases the risks of various diseases such as blind and expanded cardiomyopathy in the cats. One of the most established physiological roles of taurine is the conjugation with bile acid in the liver. In addition, taurine has effect to increase the expression and activity of bile acid synthesis rate-limiting enzyme CYP7A1. Present study purposed to evaluate the influence of taurine deficiency on bile acids in the cats fed taurine-lacking diet. Adult cats were fed the soybean protein-based diet with 0.15% taurine or without taurine for 30 weeks. Taurine concentration in serum and liver was undetectable, and bile acids in the bile were significantly decreased in the taurine-deficient cats. Taurine-conjugated bile acids in the bile were significantly decreased, and instead, unconjugated bile acids were significantly increased in the taurine-deficient cats. Present results suggested that the taurine may play an important role in the synthesis of bile acids in the liver.

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Abbreviations

APDS:

3-aminopyridyl-N-hydroxysuccinimidyl carbamate

BACS:

ATP-dependent microsomal bile acid-CoA synthetase

BAT:

bile acid-CoA:amino acid N-acetyltransferase

BW:

body weight

CA:

cholic acid

CDCA:

chenodeoxycholic acid

CDO:

cysteine dioxygenase

CSD:

cysteine sulfinate decarboxylase

CYP7A1:

cytochrome P450 7a1

DCA:

deoxycholic acid

DIA:

days in age

ESI:

electrospray ionization

FXR:

farnesoid X receptor

GCA:

glycocholic acid

GCDCA:

glycochenodeoxycholic acid

GDCA:

glycodeoxycholic acid

GLCA:

glycolithocholic acid

GUDCA:

glycoursodeoxycholic acid

HDCA:

hyodeoxycholic acid

LCA:

lithocholic acid

MCA:

muricholic acid

SRM:

selected reaction monitoring

TCA:

taurocholic acid

TCDCA:

taurochenodeoxycholic acid

TDCA:

taurodeoxycholic acid

TLCA:

taurolithocholic acid

TUDCA:

tauroursodeoxycholic acid

UDCA:

ursodeoxycholic acid

UFLC:

ultra-fast liquid chromatography

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Acknowledgements

This research was supported in part by an Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) (Ministry of Education, Culture, Sports, Science and Technology, Japan).

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Authors and Affiliations

  1. Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

    Teruo Miyazaki, Mutsumi Shirai, Tadashi Ikegami, Yasushi Matsuzaki & Akira Honda

  2. Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan

    Sei-ich Sasaki

  3. Toyo Public Health College, Tokyo, Japan

    Sei-ich Sasaki

  4. College of Agriculture, Ibaraki University, Ibaraki, Japan

    Atsushi Toyoda

Authors
  1. Teruo Miyazaki
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  2. Sei-ich Sasaki
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  3. Atsushi Toyoda
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  4. Mutsumi Shirai
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  5. Tadashi Ikegami
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  6. Yasushi Matsuzaki
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  7. Akira Honda
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Corresponding author

Correspondence to Teruo Miyazaki .

Editor information

Editors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China

    Jianmin Hu

  2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China

    Fengyuan Piao

  3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Abdeslem El Idrissi

  5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Jang-Yen Wu

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Miyazaki, T. et al. (2019). Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_4

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