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Glaucomatous Injury of Central Nerve System: The Role of Neuroimaging Technology in the Understanding of Disease

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Integrative Ophthalmology

Part of the book series: Advances in Visual Science and Eye Diseases ((AVSED,volume 3))

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Abstract

Understanding glaucoma is an endless process of continuous integration; for example glaucoma, which was firstly recognized to be a disease limited to the eye, has now been considered as a disease affecting the whole visual pathway with the characteristics of optic nerve injury in addition to corresponding visual field defects. Relevant contents have been elaborated in Chap. 6. In the process of overall integration, medical imaging technology plays an important role. There are varied approaches to study the characteristics and mechanisms of human diseases, especially with the booming progress of life science and modern molecular biology, so that the research can be carried out at the cellular level and molecular level. However, molecular biology has its insurmountable weakness—the limitation of the research object, as researchers can only inspect with clues from all kinds of animal models, autopsy of dead patients, and a small amount of local tissue from patients, and then infer to the human body. Only by morphological and functional observation in vivo could we understand the disease most authentically and effectively, which was barely possible for molecular biological method to achieve, while fortunately the imaging technology provides a means to realize the above purpose. This section discusses the role of neuroimaging techniques in understanding the process of damage to CNS by glaucoma, and it is hopefully that through reading this chapter, the readers would be able to understand advanced neuroimaging techniques used in ophthalmology nowadays; thus they would integrate the research methods of both molecular biology and imaging, the local part as the eye and the whole entire body, to provide new ideas and methods for further understanding glaucoma and other ophthalmic and nervous system diseases.

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Author information

Authors and Affiliations

  1. The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, Zhejiang, China

    Shaodan Zhang

  2. Beijing Tongren Eye Center, Beijing, China

    Guoping Qing & Huaizhou Wang

  3. Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Guoping Qing & Huaizhou Wang

  4. Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China

    Guoping Qing, Huaizhou Wang, Weiwei Chen, Ningli Wang & Jiahe Gan

  5. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Weiwei Chen

  6. Department of Ophthalmology, Peking University Third Hospital, Beijing, China

    Chun Zhang

  7. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Ningli Wang & Jiahe Gan

Authors
  1. Shaodan Zhang
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  2. Guoping Qing
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  3. Huaizhou Wang
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  4. Weiwei Chen
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  5. Chun Zhang
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  6. Ningli Wang
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  7. Jiahe Gan
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Correspondence to Ningli Wang .

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Editors and Affiliations

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Ningli Wang

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Zhang, S. et al. (2020). Glaucomatous Injury of Central Nerve System: The Role of Neuroimaging Technology in the Understanding of Disease. In: Wang, N. (eds) Integrative Ophthalmology. Advances in Visual Science and Eye Diseases, vol 3. Springer, Singapore. https://doi.org/10.1007/978-981-13-7896-6_7

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  • DOI: https://doi.org/10.1007/978-981-13-7896-6_7

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-7895-9

  • Online ISBN: 978-981-13-7896-6

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