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Uveitis and Autoimmune Diseases

  • Meifen Zhang
  • Bo Wan
Chapter
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 3)

Abstract

The uvea is the predilection site of ocular immune diseases, due to its features like peripheral immune organ, with abundant vessels and some other ocular antigenic substances such as lens and retinal antigens, which could easily induce the immune-related ocular diseases. Uveitis has many complex symptoms, signs, and causes. Additionally, limitations of understanding of immune diseases could lead to the difficulty of diagnosing. This part introduces the involvement and manifestations of autoimmune diseases on uvea, and correlation between the immune-related manifestations of uveitis and systemic immune diseases. “Get the big picture from small details” to reveal the relationship between eye diseases and immune diseases, as from the perspective of integrative medicine, it would be examined and identified for that whether the uveitis is caused by immune diseases, whether the systemic immune disease affects the eye, what is the relevant diagnostic criteria for immune-related eye diseases, what are the examinations to do, and how to treat. By the establishment of integrative medical thought, broadening minds, understanding the performance of systemic immune diseases, asking history, and checking physical signs, early diagnosis and early treatment could be made, and thus the possibility of misdiagnosis and missed diagnosis of immune-associated uveitis would be decreased.

References

  1. 1.
    Peizeng Y. Clinical uveitis. Beijing: People’s Medical Publishing House; 2004.Google Scholar
  2. 2.
    Barisani-Asenbauer T, Maca SM, Mejdoubi L, et al. Uveitis—a rare disease often associated with systemic diseases and infections—a systematic review of 2619 patients. Orphanet J Rare Dis. 2012;7:57.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Wakefield D, Chang JH, Amjadi S, et al. What is new HLA-B27 acute anterior uveitis? Ocul Immunol Inflamm. 2011;19(2):139–44.CrossRefPubMedGoogle Scholar
  4. 4.
    Zhuoli Z, Jinmin P, Xiaomeng H, et al. The meta-analysis of 1996 Chinese patients with Behcet’s disease. Beijing Med J. 2007;29(1):10–2.Google Scholar
  5. 5.
    Peizeng Y, Zhen Z, Hong W, et al. Studies on the etiologies and classification of uveitis. Chin J Ocul Fund Dis. 2002;18(4):253–5.Google Scholar
  6. 6.
    Mendoza-Pinto C, Garcia-Carrasco M, Jimenez-Hernandez M, et al. Etiopathogenesis of Behcet’s disease. Autoimmun Rev. 2010;9(4):241–5.CrossRefPubMedGoogle Scholar
  7. 7.
    Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet’s Disease. Lancet. 1990;335(8697):1078–80.Google Scholar
  8. 8.
    Davies JB, Rao PK. Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol. 2008;19(6):512–8.CrossRefPubMedGoogle Scholar
  9. 9.
    Mohsenin A, Huang JJ. Ocular manifestations of systemic inflammatory diseases. Conn Med. 2012;76(9):533–44.PubMedGoogle Scholar
  10. 10.
    Vitale AT, Graham E, de Boer JH. Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome. Ocul Immunol Inflamm. 2013;21(6):478–85.CrossRefPubMedGoogle Scholar
  11. 11.
    Pilly B, Heath G, Tschuor P, et al. Overview and recent developments in the medical management of paediatric uveitis. Expert Opin Pharmacother. 2013;14(13):1787–95.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2020

Authors and Affiliations

  • Meifen Zhang
    • 1
  • Bo Wan
    • 1
  1. 1.Department of OphthalmologyPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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