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Hyperbaric Oxygen Preconditioning-Induced Neuroprotection

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Hyperbaric Oxygenation Therapy

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Abstract

Various pretreatment measures or diverse environmental changes reduce the risk of ischemic neuronal injury. This phenomenon is well known and named as ischemic tolerance. Preconditioning is the process by which hosts can escape from hypoxic stress and acquire ischemic tolerance. We have reported that repeated preconditioning with hyperbaric oxygen (HBO preconditioning) induces ischemic tolerance in gerbil hippocampus. It has also been shown that HBO preconditioning has an effect to reduce neuronal injuries in several animal models. HBO preconditioning provides neuroprotection against focal as well as global ischemia in the brain and spinal cord. It also shows a neuroprotective effect against traumatic and surgical brain injuries. Mechanisms of ischemic tolerance induced by HBO preconditioning include the upregulation of hypoxia-inducible factor-1 and its downstream adaptive genes, the inhibition of neuronal apoptotic pathways, and the upregulation of antioxidant enzymes as well as anti-inflammatory pathways.

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Authors and Affiliations

  1. Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan

    Kojiro Wada

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  1. Kojiro Wada
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Correspondence to Kojiro Wada .

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Editors and Affiliations

  1. Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan

    Nariyoshi Shinomiya

  2. Hakodate Shintoshi Hospital, Hakodate, Hokkaido, Japan

    Yasufumi Asai

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Wada, K. (2020). Hyperbaric Oxygen Preconditioning-Induced Neuroprotection. In: Shinomiya, N., Asai, Y. (eds) Hyperbaric Oxygenation Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-13-7836-2_3

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  • DOI: https://doi.org/10.1007/978-981-13-7836-2_3

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-7835-5

  • Online ISBN: 978-981-13-7836-2

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