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Genetic Operation System of Lactic Acid Bacteria and Its Applications

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Book cover Lactic Acid Bacteria

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  • The original version of the chapter has been revised: Page 62, Line 22–23 was published with some errors which has been corrected now. A correction to this chapter can be found at https://doi.org/10.1007/978-981-13-7832-4_12

Abstract

Lactic acid bacteria (LAB), a class of commonly existing microorganisms in nature, are important components of gut commensal microflora in humans and animals. Previous studies suggested that LAB exerted specific physiological and biochemical functions on the host such as improving intestinal microbial balance, immunomodulation, inhibiting tumor growth, lowering cholesterol levels, as well as regulating blood pressure and are therefore widely used in food manufacturing and functional food development. Due to the continuous development of modern molecular biology techniques, studies regarding exploiting LAB as expression hosts in addition to fermentation starter cultures and probiotics have received increasing attention from both academia and industry. In the 1980s, some researchers initiated molecular genetic research for LAB. They characterized lactose metabolism-related genes and proteins in LAB and established preliminary DNA delivery systems for LAB. Over the past decades, owing to the advances in modern DNA sequencing and gene characterization techniques, structures and functions of LAB genomes and plasmid-related genes have been further elucidated, which lays a solid theoretical foundation for the further development of LAB-based gene expression systems (Bolotin et al. 2001; Altermann et al. 2005).

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Change history

  • 06 October 2022

    The original version of the book was inadvertently published with errors. The following corrections have been made after the original publication.

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Authors and Affiliations

  1. Jiangnan University, Wuxi, China

    Haiqin Chen, Chengcheng Ren & He Gao

  2. Shanghai Institute of Technology, Shanghai, China

    Chen Chen

  3. Dalian Polytechnic University, Dalian, China

    Chunqing Ai

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  1. Haiqin Chen
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    Wei Chen

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Chen, H., Chen, C., Ai, C., Ren, C., Gao, H. (2019). Genetic Operation System of Lactic Acid Bacteria and Its Applications. In: Chen, W. (eds) Lactic Acid Bacteria. Springer, Singapore. https://doi.org/10.1007/978-981-13-7832-4_2

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