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Alloantigens and Their Role in Immune Cytopenias

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Hematopathology

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Abstract

Immune cytopenia is a reduction in the number of mature blood cells. This can be caused by alloantigens present on the surface of blood cells i.e. red blood cells or erthyrocytes, white blood cells or leucocytes and platelets or thromobocytes. Alloantigens stimulate the immune system of host against foreign antigens causing alloimmunization and subsequent production of alloantibodies which caused decreased survival of blood cells in vivo. This chapter focuses on red blood cell antigens, human platelet antigens, human neutrophil antigens and human leucocyte antigens and their role in immune cytopenias.

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Authors and Affiliations

  1. ICMR-National Institute of Immunohaematology, Mumbai, India

    Ajit Gorakshakar & Harita Gogri

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  1. Ajit Gorakshakar
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  1. Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

    Renu Saxena

  2. Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

    Hara Prasad Pati

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Gorakshakar, A., Gogri, H. (2019). Alloantigens and Their Role in Immune Cytopenias. In: Saxena, R., Pati, H. (eds) Hematopathology. Springer, Singapore. https://doi.org/10.1007/978-981-13-7713-6_27

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