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Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

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Bioactive Natural Products for the Management of Cancer: from Bench to Bedside

Abstract

Marine floras, constituting over 90% of the oceanic biomass, are rich sources of potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides. They act as potential sources of drugs with various pharmacological properties (such as antioxidant, anti-inflammatory, antibiotic, immunostimulatory, and anticancer). Although human history depicts the use of marine floras as medicine and nutrient supplement, the search for novel pharmaceutical compounds has mostly been limited to terrestrial floras. Marine floras are taxonomically diverse, largely productive, biologically active, and chemically unique, thereby offering great scope for discovery of new anticancer drugs. The mode of action of marine flora products is through activation of macrophages, induction of apoptosis, and prevention of oxidative damage of DNA, thereby controlling carcinogenesis. This chapter focuses on the immunomodulatory and therapeutic properties of marine flora-derived products in the context of increasing cancer incidences and demand for cheaper, safer, and potent anticancer drugs. It highlights the excellent therapeutic potential of the known marine flora-derived anticancer compounds, thereby encouraging researchers to actively participate in the marine natural product drug discovery for treatment and prevention of cancer.

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References

  • Abraham I, El Sayed K, Chen Z-S, Guo H (2012) Current status on marine products with reversal effect on cancer multidrug resistance. Mar Drugs 10:2312–2321

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ahn G et al (2015) A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis. EXCLI J 14:294

    PubMed  PubMed Central  Google Scholar 

  • Alarif WM, Al-Lihaibi SS, Ayyad S-EN, Abdel-Rhman MH, Badria FA (2012) Laurene-type sesquiterpenes from the Red Sea red alga Laurencia obtusa as potential antitumor–antimicrobial agents. Eur J Med Chem 55:462–466

    Article  CAS  PubMed  Google Scholar 

  • Albuquerque IRL et al (2013) Evaluation of anti-nociceptive and anti-inflammatory activities of a heterofucan from Dictyota menstrualis. Mar Drugs 11:2722–2740

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Alessandra Gammone M, Riccioni G, Galvano F, Orazio N (2016) Novel therapeutic strategies against cancer: marine-derived drugs may be the answer? Anti-Cancer Agents Med Chem (Formerly Curr Med Chem-Anti-Cancer Agents) 16:1549–1557

    Google Scholar 

  • Andrianasolo EH, Goeger D, Gerwick WH (2007) Mitsoamide: a cytotoxic linear lipopeptide from the Madagascar marine cyanobacterium Geitlerinema sp. Pure Appl Chem 79:593–602

    Article  CAS  Google Scholar 

  • Atashrazm F, Lowenthal RM, Woods GM, Holloway AF, Karpiniec SS, Dickinson JL (2016) Fucoidan suppresses the growth of human acute promyelocytic leukemia cells in vitro and in vivo. J Cell Physiol 231:688–697

    Article  CAS  PubMed  Google Scholar 

  • Athukorala Y, Kim K-N, Jeon Y-J (2006) Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol 44:1065–1074

    Article  CAS  PubMed  Google Scholar 

  • Ayyad S-EN et al (2011) Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma. Eur J Med Chem 46:175–182

    Article  CAS  PubMed  Google Scholar 

  • Azuma I, Seya T (2001) Development of immunoadjuvants for immunotherapy of cancer. Int Immunopharmacol 1:1249–1259

    Article  CAS  PubMed  Google Scholar 

  • Bae M-A, Yamada K, Ijuin Y, Tsuji T, Yazawa K, Uemura D (1996) Aburatubolactam A, a novel inhibitor of superoxide anion generation from a marine microorganism. Heterocycl Commun 2:315–318

    Article  CAS  Google Scholar 

  • Bandaranayake W (1998) Traditional and medicinal uses of mangroves. Mangrove Salt Marshes 2:133–148

    Article  Google Scholar 

  • Barbier P, Guise S, Huitorel P, Amade P, Pesando D, Briand C, Peyrot V (2001) Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network. Life Sci 70:415–429

    Article  CAS  PubMed  Google Scholar 

  • Belofsky GN, Jensen PR, Fenical W (1999) Sansalvamide: a new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium. Tetrahedron Lett 40:2913–2916

    Article  CAS  Google Scholar 

  • Bernardo PH, Chai CL, Le Guen M, Smith GD, Waring P (2007) Structure–activity delineation of quinones related to the biologically active Calothrixin B. Bioorg Med Chem Lett 17:82–85

    Article  CAS  PubMed  Google Scholar 

  • Blokhin AV, Yoo H-D, Geralds RS, Nagle DG, Gerwick WH, Hamel E (1995) Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues. Mol Pharmacol 48:523–531

    CAS  PubMed  Google Scholar 

  • Boopathy NS, Kandasamy K, Subramanian M, You-Jin J (2011) Effect of mangrove tea extract from Ceriops decandra (Griff.) Ding Hou. on salivary bacterial flora of DMBA induced Hamster buccal pouch carcinoma. Indian J Microbiol 51:338–344

    Article  Google Scholar 

  • Bowers AA (2017) Biosynthesis: methylating mushrooms. Nat Chem Biol 13:821

    Article  CAS  PubMed  Google Scholar 

  • Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM (2008) Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc 130:11219–11222

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bringmann G et al (2005) The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain. Tetrahedron 61:7252–7265

    Article  CAS  Google Scholar 

  • Bugni TS, Andjelic CD, Pole AR, Rai P, Ireland CM, Barrows LR (2009) Biologically active components of a Papua New Guinea analgesic and anti-inflammatory lichen preparation. Fitoterapia 80:270–273

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burja AM, Banaigs B, Abou-Mansour E, Burgess JG, Wright PC (2001) Marine cyanobacteria – a prolific source of natural products. Tetrahedron 57:9347–9377

    Article  CAS  Google Scholar 

  • Burns A, Rowland I (2000) Anti-carcinogenicity of probiotics and prebiotics. Curr Issues Intest Microbiol 1:13–24

    CAS  PubMed  Google Scholar 

  • Burtin P (2003) Nutritional value of seaweeds. Electron J Environ Agric Food Chem 2:498–503

    Google Scholar 

  • Cao F, Yang Q, Shao C-L, Kong C-J, Zheng J-J, Liu Y-F, Wang C-Y (2015) Bioactive 7-oxabicyclic [6.3. 0] lactam and 12-membered macrolides from a gorgonian-derived Cladosporium sp. fungus. Mar Drugs 13:4171–4178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249

    Article  CAS  PubMed  Google Scholar 

  • Chatterji A, Kassim Z, Hassan A, Therwath A, Shaharom F (2010) Marine living resources in the practice of traditional medicine. J Coast Environ 1:41–52

    Google Scholar 

  • Chen JL, Gerwick WH, Schatzman R, Laney M (1994) Isorawsonol and related IMP dehydrogenase inhibitors from the tropical green alga Avrainvillea rawsonii. J Nat Prod 57:947–952

    Article  CAS  PubMed  Google Scholar 

  • Chen D, Wu X, Wen Z (2008) Sulfated polysaccharides and immune response: promoter or inhibitor? Panminerva Med 50:177–183

    CAS  PubMed  Google Scholar 

  • Claudio F, Stendardo B (1966) An experimental contribution to the clinical use of an algal phytocolloid (Algasol T331) in oncology. In: Proceedings of the Fifth International Seaweed Symposium, Halifax, August 25–28, 1965, Elsevier, p 369

    Chapter  Google Scholar 

  • Cumashi A et al (2007) A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17:541–552

    Article  CAS  PubMed  Google Scholar 

  • D’Ambrosio M, Guerriero A, Pietra F (1987) Sarcodictyin A and Sarcodictyin B, novel diterpenoidic alcohols esterified by (E)-N (1)-methylurocanic acid. Isolation from the Mediterranean Stolonifer Sarcodictyon roseum. Helv Chim Acta 70:2019–2027

    Article  Google Scholar 

  • Damonte EB, Matulewicz MC, Cerezo AS (2004) Sulfated seaweed polysaccharides as antiviral agents. Curr Med Chem 11:2399–2419

    Article  CAS  PubMed  Google Scholar 

  • David B, Wolfender J-L, Dias DA (2015) The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev 14:299–315

    Article  CAS  Google Scholar 

  • Davidson S, Allen S, Lim G, Anderson C, Haygood M (2001) Evidence for the biosynthesis of bryostatins by the bacterial symbiont “Candidatus Endobugula sertula” of the BryozoanBugula neritina. Appl Environ Microbiol 67:4531–4537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Delma CR, Somasundaram ST, Srinivasan GP, Khursheed M, Bashyam MD, Aravindan N (2015) Fucoidan from Turbinaria conoides: a multifaceted ‘deliverable’to combat pancreatic cancer progression. Int J Biol Macromol 74:447–457

    Article  CAS  PubMed  Google Scholar 

  • Devasagayam T, Tilak J, Boloor K, Sane KS, Ghaskadbi SS, Lele R (2004) Free radicals and antioxidants in human health: current status and future prospects. Japi 52:4

    Google Scholar 

  • Devine DA, Marsh PD (2009) Prospects for the development of probiotics and prebiotics for oral applications. J Oral Microbiol 1:1949

    Article  CAS  Google Scholar 

  • Dillehay TD, Ramirez C, Pino M, Collins MB, Rossen J, Pino-Navarro J (2008) Monte Verde: seaweed, food, medicine, and the peopling of South America. Science 320:784–786

    Article  CAS  PubMed  Google Scholar 

  • Dring MJ (2005) Stress resistance and disease resistance in seaweeds: the role of reactive oxygen metabolism. Adv Bot Res 43:175–207

    Article  CAS  Google Scholar 

  • Edelman MJ, Gandara DR, Hausner P, Israel V, Thornton D, DeSanto J, Doyle LA (2003) Phase 2 study of cryptophycin 52 (LY355703) in patients previously treated with platinum based chemotherapy for advanced non-small cell lung cancer. Lung Cancer 39:197–199

    Article  PubMed  Google Scholar 

  • Erba E et al (1999) Mode of action of thiocoraline, a natural marine compound with anti-tumour activity. Br J Cancer 80:971

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fan T (1994) Angiosuppressive therapy for cancer. Trends Pharmacol Sci 15:33–36

    Article  CAS  PubMed  Google Scholar 

  • Fenical W et al (1999) Marine derived pharmaceuticals and related bioactive compounds. National Academics Press, Washington, DC

    Google Scholar 

  • Fenical W, Jensen PR, Cheng XC (2000) Halimide, a cytotoxic marine natural product, and derivatives thereof. Google Patents

    Google Scholar 

  • Fernández J, Souto ML, Norte M (1998) Evaluation of the cytotoxic activity of polyethers isolated from Laurencia. Bioorg Med Chem 6:2237–2243

    Article  PubMed  Google Scholar 

  • Ferro V et al (2007) PI-88 and novel heparan sulphate mimetics inhibit angiogenesis. In: Seminars in thrombosis and hemostasis, vol 5. Stratton Intercontinental Medical Book Corporation, New York, c1974-, p 557

    Article  CAS  PubMed  Google Scholar 

  • Fleurence J (1999) Seaweed proteins: biochemical, nutritional aspects and potential uses. Trends Food Sci Technol 10:25–28

    Article  CAS  Google Scholar 

  • Foley SA, Szegezdi E, Mulloy B, Samali A, Tuohy MG (2011) An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro. J Nat Prod 74:1851–1861

    Article  CAS  PubMed  Google Scholar 

  • Folmer F, Jaspars M, Dicato M, Diederich M (2010) Photosynthetic marine organisms as a source of anticancer compounds. Phytochem Rev 9:557–579

    Article  CAS  Google Scholar 

  • Fouillaud M, Venkatachalam M, Girard-Valenciennes E, Caro Y, Dufossé L (2016) Anthraquinones and derivatives from marine-derived fungi: structural diversity and selected biological activities. Mar Drugs 14:64

    Article  PubMed Central  CAS  Google Scholar 

  • Frenz JL, Kohl AC, Kerr RG (2004) Marine natural products as therapeutic agents: part 2. Expert Opin Ther Pat 14:17–33

    Article  CAS  Google Scholar 

  • Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR (1992) A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem 35:3007–3011

    Article  CAS  PubMed  Google Scholar 

  • Ganesan P, Matsubara K, Ohkubo T, Tanaka Y, Noda K, Sugawara T, Hirata T (2010) Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile. Phytomedicine 17:1140–1144

    Article  CAS  PubMed  Google Scholar 

  • Guo Q, Shao Q, Xu W, Rui L, Sumi R, Eguchi F, Li Z (2017) Immunomodulatory and anti-IBDV activities of the polysaccharide AEX from Coccomyxa gloeobotrydiformis. Mar Drugs 15:36

    Article  PubMed Central  CAS  Google Scholar 

  • Gupta S, Abu-Ghannam N (2011) Recent developments in the application of seaweeds or seaweed extracts as a means for enhancing the safety and quality attributes of foods. Innov Food Sci Emerg Technol 12:600–609

    Article  CAS  Google Scholar 

  • Haefner B (2003) Drugs from the deep: marine natural products as drug candidates. Drug Discov Today 8:536–544

    Article  CAS  PubMed  Google Scholar 

  • Han L et al (2007) Unusual naphthoquinone derivatives from the twigs of Avicennia marina. J Nat Prod 70:923–927

    Article  CAS  PubMed  Google Scholar 

  • Haslam E (1996) Natural polyphenols (vegetable tannins) as drugs: possible modes of action. J Nat Prod 59:205–215

    Article  CAS  PubMed  Google Scholar 

  • Hau AM et al (2013) Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One 8:e65250

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang L, Wen K, Gao X, Liu Y (2010) Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats. Pharm Biol 48:422–426

    Article  CAS  PubMed  Google Scholar 

  • Huang C-H et al (2011) Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea. Mar Drugs 9:832–843

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang C et al (2012) The cytotoxicity and anticancer mechanisms of alterporriol L, a marine bianthraquinone, against MCF-7 human breast cancer cells. Appl Microbiol Biotechnol 93:777–785

    Article  CAS  PubMed  Google Scholar 

  • Huang L et al (2014) Anthraquinone G503 induces apoptosis in gastric cancer cells through the mitochondrial pathway. PLoS One 9:e108286

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hussain E, Wang L-J, Jiang B, Riaz S, Butt GY, Shi D-Y (2016) A review of the components of brown seaweeds as potential candidates in cancer therapy. RSC Adv 6:12592–12610

    Article  CAS  Google Scholar 

  • Irhimeh MR, Fitton JH, Lowenthal RM (2007) Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells. Exp Hematol 35:989–994

    Article  CAS  PubMed  Google Scholar 

  • Itoh H, Noda H, Amano H, Ito H (1995) Immunological analysis of inhibition of lung metastases by fucoidan (GIV-A) prepared from brown seaweed Sargassum thunbergii. Anticancer Res 15:1937–1947

    CAS  PubMed  Google Scholar 

  • Janmaat ML, Rodriguez JA, Jimeno J, Kruyt FA, Giaccone G (2005) Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling. Mol Pharmacol 68:502–510

    CAS  PubMed  Google Scholar 

  • Jaruchoktaweechai C, Suwanborirux K, Tanasupawatt S, Kittakoop P, Menasveta P (2000) New macrolactins from a marine Bacillus sp. Sc026. J Nat Prod 63:984–986

    Article  CAS  PubMed  Google Scholar 

  • Ji H-W, Shao H-Y, Zhang C-H, Hong P-Z, Xiong H-P (2007) Antitumor and immunomodulatory activities of polysaccharides from Caulerpa racemosa [J]. J Food Sci Biotechnol 4:015

    Google Scholar 

  • Ji H, Shao H, Zhang C, Hong P, Xiong H (2008a) Separation of the polysaccharides in Caulerpa racemosa and their chemical composition and antitumor activity. J Appl Polym Sci 110:1435–1440

    Article  CAS  Google Scholar 

  • Ji NY, Li XM, Xie H, Ding J, Li K, Ding LP, Wang BG (2008b) Highly oxygenated triterpenoids from the marine red alga Laurencia mariannensis (Rhodomelaceae). Helv Chim Acta 91:1940–1946

    Article  CAS  Google Scholar 

  • Ji YB, Ji CF, Zhang H (2012) Laminarin induces apoptosis of human colon cancer LOVO cells through a mitochondrial pathway. Molecules 17:9947–9960

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jiang Z, Okimura T, Yokose T, Yamasaki Y, Yamaguchi K, Oda T (2010) Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: a comparative study on ascophyllan and fucoidan. J Biosci Bioeng 110:113–117

    Article  CAS  PubMed  Google Scholar 

  • Jiao L, Li X, Li T, Jiang P, Zhang L, Wu M, Zhang L (2009) Characterization and anti-tumor activity of alkali-extracted polysaccharide from Enteromorpha intestinalis. Int Immunopharmacol 9:324–329

    Article  CAS  PubMed  Google Scholar 

  • Jiao G, Yu G, Zhang J, Ewart HS (2011) Chemical structures and bioactivities of sulfated polysaccharides from marine algae. Mar Drugs 9:196–223

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jiménez-Escrig A, Sánchez-Muniz F (2000) Dietary fibre from edible seaweeds: chemical structure, physicochemical properties and effects on cholesterol metabolism. Nutr Res 20:585–598

    Article  Google Scholar 

  • John Davis GD, Kumar V (2012) Techniques in anticancer drug discovery marine pharmacognosy: trends and applications. CRC Press, Boca Raton, p 393

    Book  Google Scholar 

  • Jones WP et al (2005) Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida. J Pharm Pharmacol 57:1101–1108

    Article  CAS  PubMed  Google Scholar 

  • Kalan AE, Rad JS, Kafami L, Mohamadnezhad D, Khaki AA, Roushandeh AM (2014) MS14, a marine herbal medicine, an immunosuppressive drug in experimental autoimmune encephalomyelitis. Iran Red Crescent Med J 16:e16956

    Google Scholar 

  • Kang S-M et al (2011) Anti-inflammatory activity of polysaccharide purified from AMG-assistant extract of Ecklonia cava in LPS-stimulated RAW 264.7 macrophages. Carbohydr Polym 85:80–85

    Article  CAS  Google Scholar 

  • Kasai Y, Komatsu K, Shigemori H, Tsuda M, Mikami Y, Kobayashi J (2005) Cladionol A, a polyketide glycoside from marine-derived fungus Gliocladium species. J Nat Prod 68:777–779

    Article  CAS  PubMed  Google Scholar 

  • Kathiresan K (2000) A review of studies on Pichavaram mangrove, southeast India. Hydrobiologia 430:185–205

    Article  Google Scholar 

  • Kathiresan K, Qasim SZ (2005) Biodiversity of mangrove ecosystems. Hindustan Publishing, New Delhi (India)

    Google Scholar 

  • Kathiresan K, Nabeel M, Manivannan S (2008) Bioprospecting of marine organisms for novel bioactive compounds. Sci Trans Environ Technovation 1:107–120

    Google Scholar 

  • Kim H (1998) Aburatubolactam C, a novel apoptosis-inducing substance produced by marine Streptomyces sp. SCRC A-20. J Microbiol Biotechnol 8(5):455–460

    Google Scholar 

  • Kim M-H, Joo H-G (2008) Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells. Immunol Lett 115:138–143

    Article  CAS  PubMed  Google Scholar 

  • Kim S-K, Wijesekara I (2010) Development and biological activities of marine-derived bioactive peptides: a review. J Funct Foods 2:1–9

    Article  CAS  Google Scholar 

  • Kim JH et al (2004) Antioxidants and inhibitor of matrix metalloproteinase-1 expression from leaves of zostera marina L. Arch Pharm Res 27:177

    Article  CAS  PubMed  Google Scholar 

  • Kim J-Y et al (2007) Methanolic extracts of Plocamium telfairiae induce cytotoxicity and caspase-dependent apoptosis in HT-29 human colon carcinoma cells. J Med Food 10:587–593

    Article  CAS  PubMed  Google Scholar 

  • Kim RK et al (2015) Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition. Cancer Sci 106:94–101

    Article  CAS  PubMed  Google Scholar 

  • Kladi M, Xenaki H, Vagias C, Papazafiri P, Roussis V (2006) New cytotoxic sesquiterpenes from the red algae Laurencia obtusa and Laurencia microcladia. Tetrahedron 62:182–189

    Article  CAS  Google Scholar 

  • Kobayashi J, Tsuda M (2004) Bioactive products from Okinawan marine micro-and macroorganisms. Phytochem Rev 3:267–274

    Article  CAS  Google Scholar 

  • Kobayashi J, Shigemori H, Ishibashi M, Yamasu T, Hirota H, Sasaki T (1991) Amphidinolides G and H: new potent cytotoxic macrolides from the cultured symbiotic dinoflagellate Amphidinium sp. J Org Chem 56:5221–5224

    Article  CAS  Google Scholar 

  • Koehn FE, Longley RE, Reed JK (1992) Microcolins A and B, new immunosuppressive peptides from the blue-green alga Lyngbya majuscula. J Nat Prod 55:613–619

    Article  CAS  PubMed  Google Scholar 

  • Kolanjinathan K, Ganesh P, Saranraj P (2014) Pharmacological importance of seaweeds: a review. World J Fish Mar Sci 6:1–15

    CAS  Google Scholar 

  • Kong C-S et al (2009a) Protective effect of isorhamnetin 3-О-β-d-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage. Food Chem Toxicol 47:1914–1920

    Article  CAS  PubMed  Google Scholar 

  • Kong C-S, Kim J-A, Yoon N-Y, Kim S-K (2009b) Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells. Food Chem Toxicol 47:1653–1658

    Article  CAS  PubMed  Google Scholar 

  • König GM, Wright AD (1996) Marine natural products research: current directions and future potential. Planta Med 62:193–211

    Article  PubMed  Google Scholar 

  • Kovarik JM, Burtin P (2003) Immunosuppressants in advanced clinical development for organ transplantation and selected autoimmune diseases. Expert Opin Emerg Drugs 8:47–62

    Article  CAS  PubMed  Google Scholar 

  • Koyanagi S, Tanigawa N, Nakagawa H, Soeda S, Shimeno H (2003) Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol 65:173–179

    Article  CAS  PubMed  Google Scholar 

  • Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V (2012) A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect 45:165–184

    Article  CAS  PubMed  Google Scholar 

  • Laphookhieo S, Cheenpracha S, Karalai C, Chantrapromma S, Ponglimanont C, Chantrapromma K (2004) Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry 65:507–510

    Article  CAS  PubMed  Google Scholar 

  • Lavakumar V, Ahamed K, Ravichandiran V (2012) Anticancer and antioxidant effect of Acanthophora spicifera against EAC induced carcinoma in mice. J Pharm Res 5:1503–1507

    Google Scholar 

  • Lee S-H et al (2012) Molecular characteristics and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava. Carbohydr Polym 89:599–606

    Article  CAS  PubMed  Google Scholar 

  • Leiro JM, Castro R, Arranz JA, Lamas J (2007) Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh Int Immunopharmacol 7:879–888

    Article  CAS  PubMed  Google Scholar 

  • Levine B, Sinha SC, Kroemer G (2008) Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 4:600–606

    Article  CAS  PubMed  Google Scholar 

  • Li B, Lu F, Wei X, Zhao R (2008) Fucoidan: structure and bioactivity. Molecules 13:1671–1695

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Z-S, Noda K, Fujita E, Manabe Y, Hirata T, Sugawara T (2014) The green algal carotenoid siphonaxanthin inhibits adipogenesis in 3T3-L1 preadipocytes and the accumulation of lipids in white adipose tissue of KK-Ay mice 1–3. J Nutr 145:490–498

    Article  PubMed  CAS  Google Scholar 

  • Li Y-X, Li Y, Je J-Y, Kim S-K (2015) Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation. Environ Toxicol Pharmacol 39:259–270

    Article  CAS  PubMed  Google Scholar 

  • Lin A-S, Engel S, Smith BA, Fairchild CR, Aalbersberg W, Hay ME, Kubanek J (2010) Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp. Bioorg Med Chem 18:8264–8269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu B-H, Lee Y-K (1999) Composition and biosynthetic pathways of carotenoids in the astaxanthin-producing green alga Chlorococcum sp. Biotechnol Lett 21:1007–1010

    Article  CAS  Google Scholar 

  • Liu L, Heinrich M, Myers S, Dworjanyn SA (2012) Towards a better understanding of medicinal uses of the brown seaweed Sargassum in traditional Chinese medicine: a phytochemical and pharmacological review. J Ethnopharmacol 142:591–619

    Article  PubMed  Google Scholar 

  • Lombó F et al (2006) Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species. Chembiochem 7:366–376

    Article  PubMed  CAS  Google Scholar 

  • Lowe SW, Lin AW (2000) Apoptosis in cancer. Carcinogenesis 21:485–495

    Article  CAS  PubMed  Google Scholar 

  • Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH (2001) Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. J Nat Prod 64:907–910

    Article  CAS  PubMed  Google Scholar 

  • Luesch H et al (2006) A functional genomics approach to the mode of action of apratoxin A. Nat Chem Biol 2:158

    Article  CAS  PubMed  Google Scholar 

  • Manivannan K, Thirumaran G, Devi GK, Hemalatha A, Anantharaman P (2008) Biochemical composition of seaweeds from Mandapam coastal regions along Southeast Coast of India. Am-Eurasian J Bot 1:32–37

    Google Scholar 

  • Marante FT, Castellano AG, Rosas FE, Aguiar JQ, Barrera JB (2003) Identification and quantitation of allelochemicals from the lichen Lethariella canariensis: phytotoxicity and antioxidative activity. J Chem Ecol 29:2049–2071

    Article  CAS  Google Scholar 

  • Maskey RP, Helmke E, Fiebig H-H, Laatsch H (2002) Parimycin: isolation and structure elucidation of a novel cytotoxic 2, 3-dihydroquinizarin analogue of γ-indomycinone from a marine Streptomycete isolate. J Antibiot 55:1031–1035

    Article  CAS  Google Scholar 

  • Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H (2004a) Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry. J Antibiot 57:771–779

    Article  CAS  Google Scholar 

  • Maskey RP, Sevvana M, Usón I, Helmke E, Laatsch H (2004b) Gutingimycin: a highly complex metabolite from a marine streptomycete. Angew Chem Int Ed 43:1281–1283

    Article  CAS  Google Scholar 

  • Matou S, Helley D, Chabut D, Bros A, Fischer A-M (2002) Effect of fucoidan on fibroblast growth factor-2-induced angiogenesis in vitro. Thromb Res 106:213–221

    Article  CAS  PubMed  Google Scholar 

  • Matsubara K, Xue C, Zhao X, Mori M, Sugawara T, Hirata T (2005) Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells. Int J Mol Med 15:695–699

    CAS  PubMed  Google Scholar 

  • Matsuda M, Yamori T, Naitoh M, Okutani K (2003) Structural revision of sulfated polysaccharide B-1 isolated from a marine Pseudomonas species and its cytotoxic activity against human cancer cell lines. Mar Biotechnol 5:13–19

    Article  CAS  Google Scholar 

  • Mayer AM et al (2010) The odyssey of marine pharmaceuticals: a current pipeline perspective. Trends Pharmacol Sci 31:255–265

    Article  CAS  PubMed  Google Scholar 

  • Medina RA et al (2008) Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp. J Am Chem Soc 130:6324–6325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Millot M, Tomasi S, Studzinska E, Rouaud I, Boustie J (2009) Cytotoxic constituents of the lichen Diploicia canescens. J Nat Prod 72:2177–2180

    Article  CAS  PubMed  Google Scholar 

  • Molinski TF, Dalisay DS, Lievens SL, Saludes JP (2009) Drug development from marine natural products. Nat Rev Drug Discov 8:69

    Article  CAS  PubMed  Google Scholar 

  • Montaser R, Luesch H (2011) Marine natural products: a new wave of drugs? Future Med Chem 3:1475–1489

    Article  CAS  PubMed  Google Scholar 

  • Montero A, Beierle JM, Olsen CA, Ghadiri MR (2009) Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic α/β-tetrapeptide architectures. J Am Chem Soc 131:3033–3041

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mshigeni KE (1990) Seaweeds in medicine and pharmacy: a global perspective. In: Proceedings of an international conference of experts from developing countries on traditional medicinal plants. The United Republic of Tanzania, Ministry of Health, Dares Salaam University Press

    Google Scholar 

  • Murti Y, Agrawal T (2010) Marine derived pharmaceuticals-development of natural health products from marine biodiversity. Int J Chem Tech Res 2:2198–2217

    CAS  Google Scholar 

  • Nagle DG, Zhou YD, Mora FD, Mohammed KA, Kim YP (2004) Mechanism targeted discovery of antitumor marine natural products. Curr Med Chem 11:1725–1756

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ngo D-H, Wijesekara I, Vo T-S, Van Ta Q, Kim S-K (2011) Marine food-derived functional ingredients as potential antioxidants in the food industry: an overview. Food Res Int 44:523–529

    Article  CAS  Google Scholar 

  • Nicholson R, Gee J, Harper M (2001) EGFR and cancer prognosis. Eur J Cancer 37:9–15

    Article  Google Scholar 

  • Noguti J, Andersen ML, Cirelli C, Ribeiro DA (2013) Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association? Sleep Breath 17:905–910

    Article  PubMed  Google Scholar 

  • Norte M, Fernández J, Souto ML, García-Grávalos MD (1996) Two new antitumoral polyether squalene derivatives. Tetrahedron Lett 37:2671–2674

    Article  CAS  Google Scholar 

  • Pacheco FC, Villa-Pulgarin JA, Mollinedo F, Martín MN, Fernández JJ, Daranas AH (2011) New polyether triterpenoids from Laurencia viridis and their biological evaluation. Mar Drugs 9:2220–2235

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Palermo JA, Flower PB, Seldes AM (1992) Chondriamides A and B, new indolic metabolites from the red alga Chondria sp. Tetrahedron Lett 33:3097–3100

    Article  CAS  Google Scholar 

  • Pallela R, Na-Young Y, Kim S-K (2010) Anti-photoaging and photoprotective compounds derived from marine organisms. Mar Drugs 8:1189–1202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele MC, Picci N (2009) Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett 283:108–117

    Article  CAS  PubMed  Google Scholar 

  • Park H-K, Kim I-H, Kim J, Nam T-J (2013) Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells. Int J Mol Med 32:291–295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Partida-Martinez LP, Hertweck C (2005) Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature 437:884

    Article  CAS  PubMed  Google Scholar 

  • Piel J, Hui D, Wen G, Butzke D, Platzer M, Fusetani N, Matsunaga S (2004) Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei. Proc Natl Acad Sci U S A 101:16222–16227

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rademaker-Lakhai JM et al (2005) Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer. Clin Cancer Res 11:1854–1862

    Article  CAS  PubMed  Google Scholar 

  • Ray GC (1988) Ecological diversity in coastal zones and oceans. In: Wilson EO, Peter FM (eds) Biodiversity. National Academies Press (US), Washington (DC), pp 36–50

    Google Scholar 

  • Reed JC (1999) Dysregulation of apoptosis in cancer. J Clin Oncol 17:2941–2941

    Article  CAS  PubMed  Google Scholar 

  • Ren H, Liu W-W (2011) Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27. Arch Pharm Res 34:901–905

    Article  CAS  PubMed  Google Scholar 

  • Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 49:1603–1616

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Romero F, Espliego F, BAZ JP, de Quesada TG, Grávalos D, De La Calle F, Fernández-Puentes JL (1997) Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. J Antibiot 50:734–737

    Article  CAS  Google Scholar 

  • Rowland S, Belt S, Wraige E, Massé G, Roussakis C, Robert J-M (2001) Effects of temperature on polyunsaturation in cytostatic lipids of Haslea ostrearia. Phytochemistry 56:597–602

    Article  CAS  PubMed  Google Scholar 

  • Sabharwal SS, Schumacker PT (2014) Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel? Nat Rev Cancer 14:709

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Scorei IR (2013) Boron-containing compounds, regulation of therapeutic potential. In: Kretsinger RH, Uversky NV, Permyako EA (eds) Encyclopedia of Metalloproteins. Springer-Verlag, New York, pp 301–308

    Chapter  Google Scholar 

  • Senthilkumar K, Manivasagan P, Venkatesan J, Kim S-K (2013) Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer. Int J Biol Macromol 60:366–374

    Article  CAS  PubMed  Google Scholar 

  • Seon-Jin L et al (2003) Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IkB kinase-dependent NF-kB activation. Mol Cells 16:97–105

    Google Scholar 

  • Shibata T, Fujimoto K, Nagayama K, Yamaguchi K, Nakamura T (2002) Inhibitory activity of brown algal phlorotannins against hyaluronidase. Int J Food Sci Technol 37:703–709

    Article  CAS  Google Scholar 

  • Shibata H et al (2003) Preventive effects of Cladosiphon fucoidan against Helicobacter pylori infection in Mongolian gerbils. Helicobacter 8:59–65

    Article  CAS  PubMed  Google Scholar 

  • Shimizu J, Wada-Funada U, Mano H, Matahira Y, Kawaguchi M, Wada M (2005) Proportion of murine cytotoxic T cells is increased by high molecular-weight fucoidan extracted from Okinawa mozuku (Cladosiphon okamuranus). J Health Sci 51:394–397

    Article  CAS  Google Scholar 

  • Shin HJ, Kim TS, Lee H-S, Park JY, Choi I-K, Kwon HJ (2008) Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973. Phytochemistry 69:2363–2366

    Article  CAS  PubMed  Google Scholar 

  • Simmons TL, McPhail KL, Ortega-Barría E, Mooberry SL, Gerwick WH (2006) Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium. Tetrahedron Lett 47:3387–3390

    Article  CAS  Google Scholar 

  • Sithranga Boopathy N, Kathiresan K (2010) Anticancer drugs from marine flora: an overview. J Oncol 2010:214186

    Article  CAS  PubMed  Google Scholar 

  • Smith CD, Zhang X (1996) Mechanism of action of cryptophycin interaction with the Vinca alkaloid domain of tubulin. J Biol Chem 271:6192–6198

    Article  CAS  PubMed  Google Scholar 

  • Smith CD, Zhang X, Mooberry SL, Patterson GM, Moore RE (1994) Cryptophycin: a new antimicrotubule agent active against drug-resistant cells. Cancer Res 54:3779–3784

    CAS  PubMed  Google Scholar 

  • Smyrniotopoulos V, Vagias C, Bruyère C, Lamoral-Theys D, Kiss R, Roussis V (2010) Structure and in vitro antitumor activity evaluation of brominated diterpenes from the red alga Sphaerococcus coronopifolius. Bioorg Med Chem 18:1321–1330

    Article  CAS  PubMed  Google Scholar 

  • Sogawa K et al (1998) Decrease of nuclear protein phosphatase 1 activity and induction of mitotic arrest and apoptosis by a marine microalgal polysaccharide in human myeloid leukemia U937 cells. Res Commun Mol Pathol Pharmacol 99:267–282

    CAS  PubMed  Google Scholar 

  • Souto ML, Manríquez CP, Norte M, Leira F, Fernández JJ (2003) The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. Bioorg Med Chem Lett 13:1261–1264

    Article  CAS  PubMed  Google Scholar 

  • Srinivas G, Babykutty S, Sathiadevan PP, Srinivas P (2007) Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev 27:591–608

    Article  CAS  PubMed  Google Scholar 

  • Steele VE et al (2001) Polyphenols and Cancer prevention. In: Chèze C, Vercauteren J, Verpoorte R (eds) Polyphenols, wine and health. Proceedings of the Phythochemical Society of Europe, vol 48. Springer, Dordrecht, pp 177–190

    Google Scholar 

  • Suárez Y, González L, Cuadrado A, Berciano M, Lafarga M, Muñoz A (2003) Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Mol Cancer Ther 2:863–872

    PubMed  Google Scholar 

  • Sugawara T, Matsubara K, Akagi R, Mori M, Hirata T (2006) Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. J Agric Food Chem 54:9805–9810

    Article  CAS  PubMed  Google Scholar 

  • Tabarsa M, Park G-M, Shin I-S, Lee E, Kim J-K, You S (2015) Structure-activity relationships of sulfated glycoproteins from Codium fragile on nitric oxide releasing capacity from RAW264. 7 cells. Mar Biotechnol 17:266–276

    Article  CAS  Google Scholar 

  • Takahashi C, Numata A, Ito Y, Matsumura E, Araki H, Iwaki H, Kushida K (1994) Leptosins, antitumour metabolites of a fungus isolated from a marine alga. J Chem Soc Perkin Trans 1:1859–1864

    Article  Google Scholar 

  • Tan LT (2007) Bioactive natural products from marine cyanobacteria for drug discovery. Phytochemistry 68:954–979

    Article  CAS  PubMed  Google Scholar 

  • Tanaka H, Nishida K, Sugita K, Yoshioka T (1999) Antitumor efficacy of hypothemycin, a new Ras-signaling. Inhibitor Cancer Sci 90:1139–1145

    CAS  Google Scholar 

  • Taori K, Paul VJ, Luesch H (2008) Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc 130:1806–1807

    Article  CAS  PubMed  Google Scholar 

  • Taskin E, Caki Z, Ozturk M (2010) Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea. Afr J Biotechnol 9:4272–4277

    Google Scholar 

  • Telles CBS et al (2018) Immunomodulatory effects and antimicrobial activity of heterofucans from Sargassum filipendula. J Appl Phycol 30:569–578

    Article  CAS  Google Scholar 

  • Thomas NV, Kim S-K (2011) Potential pharmacological applications of polyphenolic derivatives from marine brown algae. Environ Toxicol Pharmacol 32:325–335

    Article  CAS  PubMed  Google Scholar 

  • Tsang SW, Bian ZX (2015) Anti-fibrotic and anti-tumorigenic effects of Rhein, a natural anthraquinone derivative, in mammalian stellate and carcinoma cells. Phytother Res 29:407–414

    Article  CAS  PubMed  Google Scholar 

  • Umemura K, Yanase K, Suzuki M, Okutani K, Yamori T, Andoh T (2003) Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide. Biochem Pharmacol 66:481–487

    Article  CAS  PubMed  Google Scholar 

  • Usui T et al (2004) Amphidinolide H, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament. Chem Biol 11:1269–1277

    Article  CAS  PubMed  Google Scholar 

  • Varshney A, Singh V (2013) Effects of algal compounds on cancer cell line. J Exp Biol 1:337–352

    Google Scholar 

  • Vishchuk OS, Ermakova SP, Zvyagintseva TN (2013) The fucoidans from brown algae of Far-Eastern seas: anti-tumor activity and structure–function relationship. Food Chem 141:1211–1217

    Article  CAS  PubMed  Google Scholar 

  • Wang Y-Q, Miao Z-H (2013) Marine-derived angiogenesis inhibitors for cancer therapy. Mar Drugs 11:903–933

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Zhang Q, Zhang Z, Li Z (2008) Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. Int J Biol Macromol 42:127–132

    Article  PubMed  CAS  Google Scholar 

  • Wang L, Wang X, Wu H, Liu R (2014a) Overview on biological activities and molecular characteristics of sulfated polysaccharides from marine green algae in recent years. Mar Drugs 12:4984–5020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Y, Qi X, Li D, Zhu T, Mo X, Li J (2014b) Anticancer efficacy and absorption, distribution, metabolism, and toxicity studies of aspergiolide A in early drug development. Drug Des Devel Ther 8:1965

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wijesekara I, Pangestuti R, Kim S-K (2011) Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr Polym 84:14–21

    Article  CAS  Google Scholar 

  • Williams AB, Jacobs RS (1993) A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line. Cancer Lett 71:97–102

    Article  CAS  PubMed  Google Scholar 

  • Williams DE, Sturgeon CM, Roberge M, Andersen RJ (2007) Nigricanosides A and B, antimitotic glycolipids isolated from the green alga Avrainvillea nigricans collected in Dominica. J Am Chem Soc 129:5822–5823

    Article  CAS  PubMed  Google Scholar 

  • Wollowski I, Rechkemmer G, Pool-Zobel BL (2001) Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr 73:451s–455s

    Article  CAS  PubMed  Google Scholar 

  • Xie G et al (2010) SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. Br J Pharmacol 159:689–697

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu J et al (2009) Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. J Nat Prod 72:662–665

    Article  CAS  PubMed  Google Scholar 

  • Yang F et al (2010) A novel sesquiterpene hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species. Chin J Cancer 29:655–660

    Article  CAS  PubMed  Google Scholar 

  • Yang F et al (2012) Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. J Pharmacol Sci 119:214–220

    Article  CAS  PubMed  Google Scholar 

  • Yeh C-C et al (2012) Anti-proliferative effect of methanolic extract of Gracilaria tenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress. BMC Complement Altern Med 12:142

    Article  PubMed  PubMed Central  Google Scholar 

  • Yin S, Fan C-Q, Wang X-N, Lin L-P, Ding J, Yue J-M (2006) Xylogranatins A−D: novel Tetranortriterpenoids with an unusual 9, 10-s eco scaffold from Marine Mangrove Xylocarpus g ranatum. Org Lett 8:4935–4938

    Article  CAS  PubMed  Google Scholar 

  • Yin S, Wang X-N, Fan C-Q, Lin L-P, Ding J, Yue J-M (2007) Limonoids from the seeds of the marine mangrove Xylocarpus granatum. J Nat Prod 70:682–685

    Article  CAS  PubMed  Google Scholar 

  • You X, Feng S, Luo S, Cong D, Yu Z, Yang Z, Zhang J (2013) Studies on a rhein-producing endophytic fungus isolated from Rheum palmatum L. Fitoterapia 85:161–168

    Article  CAS  PubMed  Google Scholar 

  • Yue PY et al (2017) Angiosuppressive properties of marine-derived compounds – a mini review. Environ Sci Pollut Res 24:8990–9001

    Article  Google Scholar 

  • Zhang L-H, Longley RE, Koehn FE (1997) Antiproliferative and immunosuppressive properties of microcolin A, a marine-derived lipopeptide. Life Sci 60:751–762

    Article  CAS  PubMed  Google Scholar 

  • Zhang A, Ding C, Cheng C, Yao Q (2007) Convenient synthesis of 2, 7-naphthyridine lophocladines A and B and their analogues. J Comb Chem 9:916–919

    Article  CAS  PubMed  Google Scholar 

  • Zhang J-L, Tian H-Y, Li J, Jin L, Luo C, Ye W-C, Jiang R-W (2012) Steroids with inhibitory activity against the prostate cancer cells and chemical diversity of marine alga Tydemania expeditionis. Fitoterapia 83:973–978

    Article  CAS  PubMed  Google Scholar 

  • Zhang G, Zhang Z, Liu Z (2013) Scytonemin inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in multiple myeloma cells. Tumor Biol 34:2241–2247

    Article  CAS  Google Scholar 

  • Zhuang C, Itoh H, Mizuno T, Ito H (1995) Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii). Biosci Biotechnol Biochem 59:563–567

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We are grateful to the Director, TIFR-National Centre for Biological Sciences (NCBS), for his support and encouragement. We appreciate the valuable suggestions given by Dr. Swatantar Kumar (Max Planck Institute for Biogeochemistry, Jena, Germany) and Dr. Sanjukta Mukherjee (TIFR-NCBS, India) during manuscript preparations. This work was supported by NCBS.

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  1. National Centres for Biological Sciences, TIFR, Bangalore, Karnataka, India

    Anshika Singh & Sudhir Krishna

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  1. Anshika Singh
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  2. Sudhir Krishna
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Correspondence to Anshika Singh or Sudhir Krishna .

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  1. Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala, Haryana, India

    Anil K. Sharma

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Singh, A., Krishna, S. (2019). Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer. In: Sharma, A. (eds) Bioactive Natural Products for the Management of Cancer: from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-13-7607-8_7

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