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Understanding HDL: Overview

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Book cover High-Density Lipoproteins as Biomarkers and Therapeutic Tools

Abstract

As shown in below diagram, the first leading causes of death in the world are cardiovascular disease (48%) and the second and the third one are respiratory disease (12%) and diabetes (3%). Total 63% of leading cause of death is directly related with HDL-cholesterol and its functionality. Interestingly, incidence of cancer is also associated with change of HDL-cholesterol level. Yang et al. (2015) reported that 1 mg/dL reduction of HDL-C was associated with 14% increased risk of having cancer. Furthermore, inverse correlations between HDL-C level and risk of developing cancer from several randomized controlled trials of lipid-altering therapy (Jafri et al. 2010). Although the role of low HDL-C as a causative factor of cancer remains uncertain, plasma HDL-C level was often decrease in patients with cancer (Dilman et al. 1981). Typically, cancer induced dyslipidemia showed low HDL-C in various solid tumors such as breast cancers (Touvier et al. 2015), liver cancers (Nderitu et al. 2017), and lung cancers (Chi et al. 2014).

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    Kyung-Hyun Cho

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Cho, KH. (2019). Understanding HDL: Overview. In: High-Density Lipoproteins as Biomarkers and Therapeutic Tools. Springer, Singapore. https://doi.org/10.1007/978-981-13-7387-9_1

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