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Improvement of HDL

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High-Density Lipoproteins as Biomarkers and Therapeutic Tools

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Abstract

For more than three decades, lipid-lowering therapeutic modalities have focused on lowering LDL-cholesterol levels, as is the case in statin therapy. However, the focus of research in this area is currently shifting to enhancement of HDL-level both in quantity and quality. Two approaches are currently being exploited in HDL-oriented therapy for regression to reduce atherosclerotic plaque size via stimulating cholesterol efflux. One of these involves the use of synthetic HDL with recombinant apoA-I and its mutants, and the other employs the apolipoprotein-mimetic peptide, such as D4F.

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  1. LipoLab, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South Korea

    Kyung-Hyun Cho

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Cho, KH. (2019). Improvement of HDL. In: High-Density Lipoproteins as Biomarkers and Therapeutic Tools. Springer, Singapore. https://doi.org/10.1007/978-981-13-7383-1_1

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