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Leukemia Stem Cells in Hematologic Malignancies pp 147–171Cite as

DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1143))

Abstract

In humans, hematopoietic stem cells (HSCs) adopt unique responsive pathways counteracting with the DNA-damaging assaults to weigh the balance between the maintenance of normal stem cell poor for whole-life blood regeneration and the transformation to leukemia stem cells (LSCs) for leukemia initiation. LSCs also take actions of combating with the attack launched by externally therapeutic drugs that can kill most leukemic cells, to avoid extermination and promote disease relapse. Therefore, the collection of knowledge about all these underlined mechanisms would present a preponderance for later studies. In this chapter, the universal DNA damage response (DDR) mechanisms were firstly introduced, and then DDR of HSCs were presented focusing on the DNA double-strand breaks in the quiescent state of HSCs, which poses a big advantage in promoting its transformation into preleukemic HSCs. Lastly, the DDR of LSCs were summarized based on the major outcomes triggered by different pathways in specific leukemia, upon which some aspects for future investigations were envisioned under our currently limited scope of knowledge.

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Acknowledgements

This work was supported by Ministry of Science and Technology of China (Grant No. 2016YFE0107200) and the National Natural Science Foundation of China (Grant No. 81770151).

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  1. Authors Wenjun Zhang and Guangming Wang have been contributed equally to this chapter.

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  1. Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

    Wenjun Zhang, Guangming Wang & Aibin Liang

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  1. Wenjun Zhang
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Correspondence to Aibin Liang .

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  1. Medical Research Institute, Wuhan University, Wuhan, Hubei, China

    Haojian Zhang

  2. Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA

    Shaoguang Li

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Zhang, W., Wang, G., Liang, A. (2019). DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells. In: Zhang, H., Li, S. (eds) Leukemia Stem Cells in Hematologic Malignancies. Advances in Experimental Medicine and Biology, vol 1143. Springer, Singapore. https://doi.org/10.1007/978-981-13-7342-8_7

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