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Phytotherapeutics: The Substitutes for Glioblastoma Multiforme

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Natural Bio-active Compounds

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Abstract

Glioblastoma multiforme (GBM) is classified as a grade IV brain tumors. It is a very aggressive, malignant, and lethal brain tumor having 10–15 months of median survival rate. Currently, chemotherapeutics used for treatment have limitations of low efficacy and toxicity which gets further compounded by development of chemoresistance. There is a need to explore alternative treatments for GBM to augment the existing chemotherapeutics presently in use. The plant-derived compounds through their alternate mechanism of action may have an emerging strategy to prevent brain tumor. It can be used as single compound or combined with standard chemotherapeutic. Phytochemical can help to augment the efficacy, reduce toxicity, and improve the prognosis. All across the world, a range of different types of medicinal plants exist; out of these numbers of medicinal plants have anticancer properties. It has been shown that some phytochemicals have anti-invasive, anti-angiogenic, antiproliferative, and pro-apoptotic effects under in vitro conditions, while there are far less clinical trials on phytotherapeutics to prove its efficacy. Thus, the aim of this chapter is to focus on plant-derived compounds which have anticancer properties (like curcumin, resveratrol, lycopene, gingerol, etc.) toward their effect on brain tumor and their future prospects. The development of novel therapeutics that can improve survival in patients with GBM is need of the hour.

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Authors and Affiliations

  1. Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India

    Megha Gautam, Sahil Srivastav, Niharika Tiwary, Shweta Dang & Reema Gabrani

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  1. Megha Gautam
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  2. Sahil Srivastav
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  3. Niharika Tiwary
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  4. Shweta Dang
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  5. Reema Gabrani
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Correspondence to Reema Gabrani .

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Editors and Affiliations

  1. Department of Biotechnology, East West First Grade College of Science, Bengaluru, Karnataka, India

    Mallappa Kumara Swamy

  2. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

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Gautam, M., Srivastav, S., Tiwary, N., Dang, S., Gabrani, R. (2019). Phytotherapeutics: The Substitutes for Glioblastoma Multiforme. In: Swamy, M., Akhtar, M. (eds) Natural Bio-active Compounds. Springer, Singapore. https://doi.org/10.1007/978-981-13-7205-6_9

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