Skip to main content

Natural Compounds Extracted from Medicinal Plants and Their Applications in Cardiovascular and Kidney Diseases

  • Chapter
  • First Online:
Natural Bio-active Compounds

Abstract

Natural compounds extracted from various medicinal plants have drawn a significant attention in the past few years for the treatment of a variety of diseases. Many natural compounds, such as alkaloids, phenylpropanoids, polyketides, terpenoids, etc., have been proven to possess good clinical potential, viz., antitumor, antimicrobial, antioxidant, immunosuppressant, antiprotozoal, and many others. The main focus of this book chapter is to explain the role of natural compounds in the treatment of cardiovascular and kidney diseases including acute renal failure and chronic kidney diseases. Data from the clinical studies in the past few years indicate that natural compounds from the medicinal plants have profound renal and cardioprotective potentials. Flavonoids present in citrus fruits, red wine, tea, cocoa, etc. exhibit anti-inflammatory activities, regulate blood pressure, and reduce oxidative stress. Olive oil rich in phenolic contents; omega-3 fatty acids in flaxseeds, soya beans, canola oil, and leafy vegetables; lycopene found in tomato, watermelon, and papaya; resveratrol in the skin and seeds of grapes; the bio-active ingredients of tea and coffee; and many other natural compounds like phytosterols, saponins, phenolic acids, phytic acid, isoflavones, etc. offer a safer application of them in the prevention and treatment of various chronic diseases. Natural compounds extracted from medicinal plants can be used as therapeutic adjuncts due to their widespread availability, better tolerability, lesser side effects, and their irreplaceable role in the traditional medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Afonso MS, de O Silva AM, Carvalho EB, Rivelli DP, Barros SB, Rogero MM, Lottenberg AM, Torres RP, Mancini-Filho J (2013) Phenolic compounds from rosemary (Rosmarinus officinalis L.) attenuate oxidative stress and reduce blood cholesterol concentrations in diet-induced hypercholesterolemic rats. Nutr Metab 10:19

    Article  CAS  Google Scholar 

  • Alpsoy S, Aktas C, Uygur R, Topcu B, Kanter M, Erboga M, Karakaya O, Gedikbasi A (2013) Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats. J Appl Toxicol 33:202–208

    Article  PubMed  CAS  Google Scholar 

  • Andersson C, Vasan RS (2018) Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol 15:230

    Article  PubMed  Google Scholar 

  • Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33:1582–1614

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bernatonienė J, Masteikova R, Majienė D, Savickas A, Kėvelaitis E, Bernatonienė R, Dvoráčková K, Civinskienė G, Lekas R, Vitkevičius K (2008) Free radical-scavenging activities of Crataegus monogyna extracts. Medicina 44:706–712

    Article  PubMed  Google Scholar 

  • Bhattacharya SK, Bhattacharya D, Sairam K, Ghosal S (2002) Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart. Phytomedicine 9:171–174

    Article  CAS  PubMed  Google Scholar 

  • Blanco M, Costa C, Freire A, Santos J Jr, Costa M (2009) Neurobehavioral effect of essential oil of Cymbopogon citratus in mice. Phytomedicine 16:265–270

    Article  CAS  PubMed  Google Scholar 

  • Chen BJ (2001) Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 42:253–265

    Article  CAS  PubMed  Google Scholar 

  • Chen DQ, Feng YL, Tian T, Chen H, Yin L, Zhao YY, Lin RC (2014) Diuretic and anti-diuretic activities of fractions of Alismatis rhizoma. J Ethnopharmacol 157:114–118

    Article  CAS  PubMed  Google Scholar 

  • Choi JH, Rho M-C, Lee SW, Kwon OE, Park HR, Kang JY, Lee SH, Lee HS, Bae KH, Kim YK (2007) Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. J Ethnopharmacol 110:563–566

    Article  CAS  PubMed  Google Scholar 

  • Daozong X, Jieer L, Peipei C (2009) The scavenging activities of total flavonoids from Plantago asiatica Linn. on free radicals and its protective effects on oxidative damage in mice. Bull Sci Technol 6:018

    Google Scholar 

  • De Lorgeril M, Salen P, Martin J-L, Monjaud I, Delaye J, Mamelle N (1999) Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon diet heart study. Circulation 99:779–785

    Article  PubMed  Google Scholar 

  • Di Mambro VM, Fonseca MJ (2005) Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts. J Pharm Biomed Anal 37:287–295

    Article  PubMed  CAS  Google Scholar 

  • Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Metabolites 2:303–336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Elkayam A, Peleg E, Grossman E, Shabtay Z, Sharabi Y (2013) Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats. Isr Med Assoc J 15:170–173

    PubMed  Google Scholar 

  • Ernst E (1987) Cardiovascular effects of garlic (Allium sativum): a review. Pharmatherapeutica 5(2):83–89

    CAS  PubMed  Google Scholar 

  • Fan SH, Zhang ZF, Zheng YL, Lu J, Wu DM, Shan Q, Hu B, Wang YY (2009) Troxerutin protects the mouse kidney from D-galactose-caused injury through anti-inflammation and anti-oxidation. Int Immunopharmacol 9:91–96

    Article  CAS  PubMed  Google Scholar 

  • Fang ZY, Lin R, Yuan BX, Yang GD, Liu Y, Zhang H (2008) Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit. J Ethnopharmacol 115:217–222

    Article  CAS  PubMed  Google Scholar 

  • Fitó M, Cladellas M, De La Torre R, Marti J, Alcantara M, Pujadas-Bastardes M, Marrugat J, Bruguera J, López-Sabater M, Vila J (2005) Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis 181:149–158

    Article  PubMed  CAS  Google Scholar 

  • Gu WZ, Banerjee S, Rauch J, Brandwein SR (1992) Suppression of renal disease and arthritis, and prolongation of survival in MRL-lpr mice treated with an extract of tripterygium wilfordii hook F. Arthritis Rheumatol 35:1381–1386

    Article  CAS  Google Scholar 

  • Guo Z (1992) Electrophysiological effects of neferine against ischemic ventricular tachyarrhythmias. Zhonghua Xin Xue Guan Bing Za Zhi 20:119–122

    CAS  PubMed  Google Scholar 

  • Han R, Rostami-Yazdi M, Gerdes S, Mrowietz U (2012) Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases. Br J Clin Pharmacol 74:424–436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hattori T, Hayashi K, Nagao T, Furuta K, Ito M, Suzuki Y (1992) Studies on antinephritic effects of plant components (3): effect of pachyman, a main component of Poria cocos Wolf on original-type anti-GBM nephritis in rats and its mechanisms. Jpn J Pharmacol 59:89–96

    Article  CAS  PubMed  Google Scholar 

  • Hernández TF, Rodríguez-Rodríguez E, Sanchez-Muniz FJ (2004) The green tea, a good choice for cardiovascular disease prevention. Arch Latinoam Nutr 54:380–394

    Google Scholar 

  • Javaid R, Aslam M, Nizami Q, Javaid R (2012) Role of antioxidant herbal drugs in renal disorders: an overview. Free Radicals Antioxid 2:2–5

    Article  CAS  Google Scholar 

  • Jha V (2010) Herbal medicines and chronic kidney disease. Nephrology 15:10–17

    Article  PubMed  Google Scholar 

  • Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY-M, Yang C-W (2013) Chronic kidney disease: global dimension and perspectives. Lancet 382:260–272

    Article  PubMed  Google Scholar 

  • Kang DG, Oh H, Sohn EJ, Hur TY, Lee KC, Kim KJ, Kim TY, Lee HS (2004) Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats. Life Sci 75:1801–1816

    Article  CAS  PubMed  Google Scholar 

  • Kim HS, Zhang YH, Oh KW, Ahn HY (1997) Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat. J Ethnopharmacol 58:117–123

    Article  CAS  PubMed  Google Scholar 

  • Kivimäki M, Steptoe A (2018) Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol 15:215

    Article  PubMed  CAS  Google Scholar 

  • Koçyõldõz ZÇ, Birman H, Olgaç V, Akgün-Dar K, Melikoğlu G, Meriçli A (2006) Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study. Phytother Res 20:66–70

    Article  Google Scholar 

  • Kuang S, Zheng X, Yang YB, Yan PK, Li K, Liao DF (2008) Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells. Acta Pharmacol Sin 29:555–563

    Article  PubMed  CAS  Google Scholar 

  • Langmead L, Rampton D (2001) Herbal treatment in gastrointestinal and liver disease-benefits and dangers. Aliment Pharmacol Ther 15:1239–1252

    Article  CAS  PubMed  Google Scholar 

  • Lee SM, Lee YJ, Yoon JJ, Kang DG, Lee HS (2012) Effect of Poria cocos on hypertonic stress-induced water channel expression and apoptosis in renal collecting duct cells. J Ethnopharmacol 141:368–376

    Article  PubMed  Google Scholar 

  • Levey AS, Coresh J, Bolton K, Culleton B, Harvey KS, Ikizler TA, Johnson CA, Kausz A, Kimmel PL, Kusek J (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39:S1–S266

    Google Scholar 

  • Li L (1996) End-stage renal disease in China. Kidney Int 49:287–301

    Article  CAS  PubMed  Google Scholar 

  • Li X, Wang H (2005) Chinese herbal medicine in the treatment of chronic kidney disease. Adv Chronic Kidney Dis 12:276–281

    Article  PubMed  Google Scholar 

  • Li L, Tao X, Yang G, Luo W (2001) Regulation effect of sodium ferulate on endothelial dysfunction in renal failure patient. Zhongguo Zhong Xi Yi Jie He Shen Bing Za Zhi 2:236–237

    Google Scholar 

  • Li P, Gong Y, Zu N, Li Y, Wang B, Shimizu F (2005) Therapeutic mechanism of Saikosaponin-d in anti-Thy1 mAb 1-22-3-induced rat model of glomerulonephritis. Nephron Exp Nephrol 101(4):e111–e118

    Article  CAS  PubMed  Google Scholar 

  • Li M, Wang W, Xue J, Gu Y, Lin S (2011) Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol 133:412–419

    Article  PubMed  Google Scholar 

  • Liu Q (2011) Triptolide and its expanding multiple pharmacological functions. Int J Immunopharmacol 11:377–383

    Article  CAS  Google Scholar 

  • Liu Y, Zhang H-G, Jia Y, Li X-H (2010) Panax notoginseng saponins attenuate atherogenesis accelerated by zymosan in rabbits. Biol Pharm Bull 33:1324–1330

    Article  CAS  PubMed  Google Scholar 

  • Lobo V, Patil A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4:118

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • London GM, Marchais SJ, Guerin AP, Metivier F, Adda H (2002) Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant 17:1713–1724

    Article  PubMed  Google Scholar 

  • Manna P, Sinha M, Sil PC (2006) Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med 6:33

    Article  PubMed  PubMed Central  Google Scholar 

  • Mashour NH, Lin GI, Frishman WH (1998) Herbal medicine for the treatment of cardiovascular disease: clinical considerations. Arch Intern Med 158:2225–2234

    Article  CAS  PubMed  Google Scholar 

  • Mathur R, Sharma A, Dixit V, Varma M (1996) Hypolipidaemic effect of fruit juice of Emblica officinalis in cholesterol-fed rabbits. J Ethnopharmacol 50:61–68

    Article  CAS  PubMed  Google Scholar 

  • Meng L, Qu L, Tang J, Cai SQ, Wang H, Li X (2007) A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. Vasc Pharmacol 47:174–183

    Article  CAS  Google Scholar 

  • Mimić-Oka J, Simić DV, Simić TP (1999) Free radicals in cardiovascular diseases. Med Biol 6:11–22

    Google Scholar 

  • Mohanty I, Arya DS, Dinda A, Joshi S, Talwar KK, Gupta SK (2004) Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Life Sci 75:1701–1711

    Article  CAS  PubMed  Google Scholar 

  • Nizamutdinova IT, Oh HM, Min YN, Park SH, Lee MJ, Kim JS, Yean MH, Kang SS, Kim YS, Chang KC (2007) Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-κB signaling pathways. Int Immunopharmacol 7:343–350

    Article  CAS  PubMed  Google Scholar 

  • Palipoch S (2013) A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants. Afr J Tradit Complement Altern Med 10:88–93

    CAS  PubMed  PubMed Central  Google Scholar 

  • Peng A, Gu Y, Lin S (2005) Herbal treatment for renal diseases. Ann Acad Med Singap 34:44–51

    CAS  PubMed  Google Scholar 

  • Prakash D, Singh BN, Upadhyay G (2007) Antioxidant and free radical scavenging activities of phenols from onion (Allium cepa). Food Chem 102:1389–1393

    Article  CAS  Google Scholar 

  • Qiu D, Kao PN (2003) Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii hook F. Drugs RD 4:1–18

    Article  CAS  Google Scholar 

  • Rafieian-kopaei M (2013) Medicinal plants for renal injury prevention. J Renal Inj Prev 2:63

    PubMed  PubMed Central  Google Scholar 

  • Rajendran S, Deepalakshmi P, Parasakthy K, Devaraj H, Devaraj SN (1996) Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis 123:235–241

    Article  CAS  PubMed  Google Scholar 

  • Ren D, Tao Y, Feng W (2001) Effect of Ligusticum on blood endothelial level and renal function in renal failure patients. Zhongguo Zhong Xi Yi Jie He Shen Bing Za Zhi 2:234–235

    Google Scholar 

  • Revathi K, Kumar C, Thamizhavahan K (2012) Combined antimicrobial activity of lemon grass oil and Tulasi oil. Int J Preclinical Pharm Res 3:79–81

    Google Scholar 

  • Ruparelia N, Chai JT, Fisher EA, Choudhury RP (2017) Inflammatory processes in cardiovascular disease: a route to targeted therapies. Nat Rev Cardiol 14:133

    Article  CAS  PubMed  Google Scholar 

  • Saravanan N, Nalini N (2007) Impact of Hemidesmus indicus R. Br. extract on ethanol-mediated oxidative damage in rat kidney. Redox Rep 12:229–235

    Article  CAS  PubMed  Google Scholar 

  • Saravanan G, Prakash J (2004) Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats. J Ethnopharmacol 94:155–158

    Article  CAS  PubMed  Google Scholar 

  • Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, McCullough PA, Kasiske BL, Kelepouris E, Klag MJ (2003) Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention. Circulation 108:2154–2169

    Article  PubMed  Google Scholar 

  • Shukla SK, Gupta S, Ojha SK, Sharma SB (2010) Cardiovascular friendly natural products: a promising approach in the management of CVD. Nat Prod Res 24:873–898

    Article  CAS  PubMed  Google Scholar 

  • Sinclair S (1998) Chinese herbs: a clinical review of Astragalus, Ligusticum, and Schizandrae. Altern Med Rev 3:338–344

    CAS  PubMed  Google Scholar 

  • Sohn S-H, Lee H, Nam JY, Kim SH, Jung HJ, Kim Y, Shin M, Hong M, Bae H (2009) Screening of herbal medicines for the recovery of cisplatin-induced nephrotoxicity. Environ Toxicol Pharmacol 28:206–212

    Article  CAS  PubMed  Google Scholar 

  • Soleas GJ, Diamandis EP, Goldberg DM (1997) Resveratrol: a molecule whose time has come? And gone? Clin Biochem 30:91–113

    Article  CAS  PubMed  Google Scholar 

  • Song H, Wang Z, Zhang F (2000) Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it. Chin J Integr Med 20:107–109

    CAS  Google Scholar 

  • Song J, Meng L, Li S, Qu L, Li X (2009) A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats. Vasc Pharmacol 50:185–193

    Article  CAS  Google Scholar 

  • Swamy AV, Gulliaya S, Thippeswamy A, Koti BC, Manjula DV (2012) Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmcol 44:73

    Article  CAS  Google Scholar 

  • Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A (2005) Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005) The Task Force for the diagnosis and treatment of chronic heart failure of the European Society of Cardiology. Eur Heart J 26:1115–1140

    Article  PubMed  Google Scholar 

  • Tam WY, Chook P, Qiao M, Chan LT, Chan TY, Poon YK, Fung KP, Leung PC, Woo KS (2009) The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients. J Altern Complement Med 15:415–421

    Article  PubMed  Google Scholar 

  • Tian T, Chen H, Zhao Y-Y (2014) Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: a review. J Ethnopharmacol 158:373–387

    Article  CAS  PubMed  Google Scholar 

  • Turk-Adawi K, Sarrafzadegan N, Fadhil I, Taubert K, Sadeghi M, Wenger NK, Tan NS, Grace SL (2018) Cardiovascular disease in the eastern Mediterranean region: epidemiology and risk factor burden. Nat Rev Cardiol 15:106

    Article  PubMed  Google Scholar 

  • Uttara B, Singh AV, Zamboni P, Mahajan R (2009) Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 7:65–74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44–84

    Article  CAS  PubMed  Google Scholar 

  • Verma S, Singh S (2008) Current and future status of herbal medicines. Vet World 11:347–350

    Article  Google Scholar 

  • Wang X, Yu R, Guo J, Wu Y, WU X (2000) Effect of extract from overground part of Tripterygium wilfordii hook. F. on masugi nephritis in rabbits. J Chinese Mater Med 25:231–233

    CAS  Google Scholar 

  • Wang J, Zhao Y, Xiao X, Li H, Zhao H, Zhang P, Jin C (2009) Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats. J Ethnopharmacol 124:18–25

    Article  PubMed  Google Scholar 

  • Wojcikowski K, Johnson DW, Gobe G (2006) Herbs or natural substances as complementary therapies for chronic kidney disease: ideas for future studies. J Lab Clin Med 147:160–166

    Article  PubMed  Google Scholar 

  • Xie S, Jin Q (1993) Prevention of sinomenine on isolated rat myocardial reperfusion injury. Acta Pharmacol Sin 14:S12–S15

    CAS  Google Scholar 

  • Yan LP, Chan SW, Chan ASC, Chen SL, Ma XJ, Xu HX (2006) Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci 79:324–330

    Article  CAS  PubMed  Google Scholar 

  • Yang PY, Almofti MR, Lu L, Kang H, Zhang J, Li TJ, Rui YC, Sun LN, Chen WS (2005) Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum. J Pharmacol Sci 99:294–300

    Article  CAS  PubMed  Google Scholar 

  • Yokozawa T, Zhou JJ, Hattori M, Inaba S, Okada T, Oura H, Nonaka GI, Nishioka I (1995) Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats. Jpn J Nephrol 37:105–111

    CAS  Google Scholar 

  • Zeng J, Cao H, Li Q, Xu Z, Guo Z (1996) Effects of oxymatrine on arrhythmia in dogs with myocardial infarction. Acta Pharmacol Sin 17:379–382

    CAS  Google Scholar 

  • Zhang HW, Lin ZX, Xu C, Leung C, Chan LS (2014a) Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database Syst Rev 10:CD008369. https://doi.org/10.1002/14651858.CD008369.pub2

    Article  Google Scholar 

  • Zhang T, Yang S, Du J (2014b) Protective effects of berberine on isoproterenol-induced acute myocardial ischemia in rats through regulating HMGB1-TLR4 axis. Evid-Based Complement Alternat Med 2014:849783. https://doi.org/10.1155/2014/849783

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhao X, Zhang J, Tong N, Liao X, Wang E, Li Z, Luo Y, Zuo H (2011) Berberine attenuates doxorubicin-induced cardiotoxicity in mice. J Int Med Res 39:1720–1727

    Article  CAS  PubMed  Google Scholar 

  • Zhao YY, Feng YL, Bai X, Tan XJ, Lin RC, Mei Q (2013) Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism. PLoS One 8:e59617

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou Z, Liu Y, Miao AD, Wang SQ (2005) Salvianolic acid B attenuates plasminogen activator inhibitor type 1 production in TNF-α treated human umbilical vein endothelial cells. J Cell Biochem 96:109–116

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Priyadarshini .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Faujdar, C., Priyadarshini (2019). Natural Compounds Extracted from Medicinal Plants and Their Applications in Cardiovascular and Kidney Diseases. In: Swamy, M., Akhtar, M. (eds) Natural Bio-active Compounds. Springer, Singapore. https://doi.org/10.1007/978-981-13-7205-6_13

Download citation

Publish with us

Policies and ethics