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Hue and Cry

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Shed Tears for Diagnostics

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Abstract

This section covers interesting aspects of tear-based syndromes, artificial tears, those obtained from women in different stages of their lifecycle, babies and twins.Tear chemistry of contact lens users has been discussed in some detail.

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References: Author’s Tears

  • Acera A, Vecino E, Duran JA (2013) Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis. Invest Ophthalmol Vis Sci 54:8285–8291

    CAS  PubMed  Google Scholar 

  • Adams J, Schaaf CP (2018) Diagnosis and genetics of alacrima. Clin Genet 94:54–60

    Article  CAS  PubMed  Google Scholar 

  • Aho VV, Paavilainen V, Nevalainen TJ, Peuravuori H, Saari KM (2003a) Diurnal variation in group IIa phospholipase A2 content in tears of contact lens wearers and normal controls. Graefes Arch Clin Exp Ophthalmol 241:85–88

    CAS  PubMed  Google Scholar 

  • Aho VV, Holopainen JM, Tervo T, Moilanen JA et al (2003b) Group IIA phospholipase A(2) content in tears of patients having photorefractive keratectomy. J Cataract Refract Surg 29:2163–2167

    PubMed  Google Scholar 

  • Akar Y, Cira A, Apaydin C, Erman MA, Yilmaz A (2004) The effect of prematurity on tear production. Curr Eye Res 28:145–151

    Article  PubMed  Google Scholar 

  • Alevi D, Perry HD, Wedel A, Rosenberg E et al (2017) Effect of sleep position on the ocular surface. Cornea 36:567–571

    PubMed  Google Scholar 

  • Am M, Ra F, El-Naggar AH, Tm A, Akhtar S (2018) Structure and microanalysis of tear film ferning of camel tears, human tears, and Refresh Plus. Mol Vis 24:305–314

    PubMed  PubMed Central  Google Scholar 

  • Ananthi S, Santhosh RS, Nila MV, Prajna NV et al (2011) Comparative proteomics of human male and female tears by two-dimensional electrophoresis. Exp Eye Res 92:454–463

    CAS  PubMed  Google Scholar 

  • Apt L, Cullen BF (1964) Newborns do secrete tears. JAMA 189:951–953

    Article  CAS  PubMed  Google Scholar 

  • Baca JT, Finegold DN, Asher SA (2007a) Tear glucose analysis for the noninvasive detection and monitoring of diabetes mellitus. Ocul Surf 5:280–293

    Article  PubMed  Google Scholar 

  • Baca JT, Taormina CR, Feingold E, Finegold DN et al (2007b) Mass spectral determination of fasting tear glucose concentrations in nondiabetic volunteers. Clin Chem 53:1370–1372

    Article  CAS  PubMed  Google Scholar 

  • Badamchian M, Damavandy AA, Damavandy H, Wadhwa SD et al (2007) Identification and quantification of thymosin beta4 in human saliva and tears. Ann N Y Acad Sci 1112:458–465

    CAS  PubMed  Google Scholar 

  • Badugu R, Jeng BH, Reece EA, Lakowicz JR (2018) Contact lens to measure individual ion concentrations in tears and applications to dry eye disease. Anal Biochem 542:84–94

    CAS  PubMed  Google Scholar 

  • Bae SH, Shin YJ, Kim HK, Hyon JY et al (2016) Vitamin D supplementation for patients with dry eye syndrome refractory to conventional treatment. Sci Rep 6:33083

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bagheri A, Najmi H, Salim RE, Yazdani S (2015) Tear condition following unilateral ptosis surgery. Orbit 34:66–71

    PubMed  Google Scholar 

  • Baker GR, Morton M, Rajapaska RS, Bullock M et al (2006) Altered tear composition in smokers and patients with graves ophthalmopathy. Arch Ophthalmol 124:1451–1456

    CAS  PubMed  Google Scholar 

  • Bakhurji S, Yassin SA, Abdulhameed RM (2018) A healthy infant with bloody tears: case report and mini-review of the literature. Saudi J Ophthalmol 32:246–249

    PubMed  Google Scholar 

  • Balasubramanian SA, Pye DC, Willcox MD (2012a) Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus. Exp Eye Res 96:132–137

    CAS  PubMed  Google Scholar 

  • Balasubramanian SA, Pye DC, Willcox MD (2013a) Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus. Clin Exp Optom 96:214–218

    PubMed  Google Scholar 

  • Baleriola-Lucas C, Willcox MD (1998) The ability of ocular bacteria to bind to fibronectin. Clin Exp Optom 81:81–87

    Article  Google Scholar 

  • Baleriola-Lucas C, Fukuda M, Willcox MD, Sweeney DF, Holden BA (1997) Fibronectin concentration in tears of contact lens wearers. Exp Eye Res 64:37–43

    Article  CAS  PubMed  Google Scholar 

  • Barba Gallardo LF, Munoz Ortega MH, Ventura Juarez J, Aldaba Muruato LR et al (2018) Extended low oxygen transmissibility contact lens use induces alterations in the concentration of proinflammatory cytokines, enzymes and electrolytes in tear fluid. Exp Ther Med 15:4291–4297

    PubMed  PubMed Central  Google Scholar 

  • Barrett A, Gnehm D, Jones J, Trask BC (2014) alpha1-antitrypsin and C-reactive protein levels in tear fluid after continuous contact lens wear. Clin Exp Optom 97:66–71

    Article  PubMed  Google Scholar 

  • Battat L, Macri A, Dursun D, Pflugfelder SC (2001) Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology 108:1230–1235

    CAS  PubMed  Google Scholar 

  • Beden U, Turgut-Coban D, Aygun C, Ulu-Gungor I et al (2008) Tear secretion and ferning patterns among premature and full-term newborns. Turk J Pediatr 50:155–159

    PubMed  Google Scholar 

  • Benito MJ, Gonzalez-Garcia MJ, Teson M, Garcia N et al (2014) Intra- and inter-day variation of cytokines and chemokines in tears of healthy subjects. Exp Eye Res 120:43–49

    CAS  PubMed  Google Scholar 

  • Benlloch-Navarro S, Franco I, Sanchez-Vallejo V, Silvestre D et al (2013) Lipid peroxidation is increased in tears from the elderly. Exp Eye Res 115:199–205

    CAS  PubMed  Google Scholar 

  • Bitton E, Keech A, Jones L, Simpson T (2008) Subjective and objective variation of the tear film pre- and post-sleep. Optom Vis Sci 85:740–749

    PubMed  Google Scholar 

  • Borderie VM, Gineys R, Goldschmidt P, Batellier L et al (2012) Association of anti-herpes simplex virus IgG in tears and serum with clinical presentation in patients with presumed herpetic simplex keratitis. Cornea 31:1251–1256

    PubMed  Google Scholar 

  • Butrus SI, Ochsner KI, Abelson MB, Schwartz LB (1990) The level of tryptase in human tears. An indicator of activation of conjunctival mast cells. Ophthalmology 97:1678–1683

    CAS  PubMed  Google Scholar 

  • Byun YS, Lee HJ, Shin S, Chung SH (2017) Elevation of autophagy markers in Sjogren syndrome dry eye. Sci Rep 7:17280

    PubMed  PubMed Central  Google Scholar 

  • Caffery BE (1991) Influence of diet on tear function. Optom Vis Sci 68:58–72

    CAS  PubMed  Google Scholar 

  • Careba I, Chiva A, Totir M, Ungureanu E, Gradinaru S (2015a) Tear lipocalin, lysozyme and lactoferrin concentrations in postmenopausal women. J Med Life 8(Spec Issue):94–98

    CAS  PubMed  PubMed Central  Google Scholar 

  • Careba I, Gradinaru D, Chiva A, Totir M et al (2015b) Correlations between eyelid tumors and tear lipocalin, lysozyme and lactoferrin concentrations in postmenopausal women. J Med Life 8:94–98

    CAS  PubMed  PubMed Central  Google Scholar 

  • Carney LG (1991) Considerations in contact lens use under adverse conditions: proceedings of a symposium. The National Academies Press, Washington, DC

    Google Scholar 

  • Carney LG, Hill RM (1976) Human tear pH. Diurnal variations. Arch Ophthalmol 94:821–824

    CAS  PubMed  Google Scholar 

  • Carracedo G, Carpena C, Concepcion P, Diaz V et al (2017) Presence of melatonin in human tears. J Optom 10:3–4

    PubMed  Google Scholar 

  • Chiva A (2011) Electrophoresis of tear proteins as a new diagnostic tool for two high risk groups for dry eye: computer users and contact lens wearers. J Med Life 4:228–233

    PubMed  PubMed Central  Google Scholar 

  • Chong RS, Jiang YZ, Boey PY, Yu SJ et al (2010) Tear cytokine profile in medicated glaucoma patients: effect of monocyte chemoattractant protein 1 on early posttrabeculectomy outcome. Ophthalmology 117:2353–2358

    PubMed  Google Scholar 

  • Choy CK, Benzie IF, Cho P (2000) Ascorbic acid concentration and total antioxidant activity of human tear fluid measured using the FRASC assay. Invest Ophthalmol Vis Sci 41:3293–3298

    CAS  PubMed  Google Scholar 

  • Choy C, Benzie I, Cho P (2003) Antioxidants in tears and plasma: Inter-relationships and effect of vitamin C supplementation. Curr Eye Res 27:55–60

    PubMed  Google Scholar 

  • Claustrat B, Leston J (2015) Melatonin: physiological effects in humans. Neurochirurgie 61:77–84

    CAS  PubMed  Google Scholar 

  • Coles WH, Jaros PA (1984) Dynamics of ocular surface pH. Br J Ophthalmol 68:549–552

    CAS  PubMed  PubMed Central  Google Scholar 

  • Colligris B, Alkozi HA, Pintor J (2014) Recent developments on dry eye disease treatment compounds. Saudi J Ophthalmol 28:19–30

    PubMed  Google Scholar 

  • Cortes M, Esposito G, Sacco R, Gillet VB et al (2018) NGF and iNOS changes in tears from video display terminal workers. Curr Eye Res 43:1119–1125

    CAS  PubMed  Google Scholar 

  • Craig JP, Müller A, McGhee CNJ (2005) Comparison of artificial tear supplements on the ocular surface health and tear film in patients with dry eye. Ocul Surf 3:S55

    Article  Google Scholar 

  • Cumurcu T, Gunduz A, Cumurcu BE, Gul IG et al (2013) The changes in tear film parameters and impression cytology in heavily drinking men. Cornea 32:237–241

    PubMed  Google Scholar 

  • da Silva CM, de Sousa RA, Baptista AM (2013) Assessment of tear amount in subjects under the effect of (inhaled) cocaine. J Psychoactive Drugs 45:195–198

    PubMed  Google Scholar 

  • Dahl H, Dahl C (1985) Hydrogen ion concentration of tear fluid in newborn infants. Acta Ophthalmol (Copenh) 63:692–694

    Article  CAS  Google Scholar 

  • Daniel E, Duriasamy M, Ebenezer GJ, Shobhana, Job CK (2004) Elevated free tear lactoferrin levels in leprosy are associated with Type 2 reactions. Indian J Ophthalmol 52:51–56

    PubMed  Google Scholar 

  • de Oliveira D, Gomes-Ferreira PH, Carrasco LC, de Deus CB et al (2016) The importance of correct diagnosis of crocodile tears syndrome. J Craniofac Surg 27:e661–e662

    Article  PubMed  Google Scholar 

  • Deai T, Fukuda M, Tomoda Y, Higaki S et al (2004) Excimer laser photokeratectomy reactivates latent herpes simplex virus. Jpn J Ophthalmol 48:570–572

    PubMed  Google Scholar 

  • Deinema LA, Vingrys AJ, Wong CY, Jackson DC et al (2017) A randomized, double-masked, placebo-controlled clinical trial of two forms of omega-3 supplements for treating dry eye disease. Ophthalmology 124:43–52

    PubMed  Google Scholar 

  • Demirci G, Karaman Erdur S, Ozsutcu M, Eliacik M et al (2018) Dry eye assessment in patients with vitamin D deficiency. Eye Contact Lens 44(Suppl 1):S62–S65

    PubMed  Google Scholar 

  • Dogru M, Kojima T, Matsumoto Y, Ibrahim O et al (2010) The early effects of alcohol consumption on tear functions and ocular surface. Invest Ophthalmol Vis Sci 51:6257

    Google Scholar 

  • Dogru M, Ward SK, Wakamatsu T, Ibrahim O et al (2011) The effects of 2 week senofilcon-A silicone hydrogel contact lens daily wear on tear functions and ocular surface health status. Cont Lens Anterior Eye 34:77–82

    Article  PubMed  Google Scholar 

  • Downie LE, Gad A, Wong CY, Gray JHV et al (2018) Modulating contact lens discomfort with anti-inflammatory approaches: a randomized controlled trial. Invest Ophthalmol Vis Sci 59:3755–3766

    CAS  PubMed  Google Scholar 

  • Dutta S, Islam MN, Chakroborty S, Mondal A et al (2014) Effect of anti-oxidant on tear film in patients suffering from diabetes mellitus. J Indian Med Assoc 112:108–109

    PubMed  Google Scholar 

  • Ebeigbe JA, Ebeigbe PN (2014) The influence of sex hormone levels on tear production in postmenopausal Nigerian women. Afr J Med Med Sci 43:205–211

    CAS  PubMed  Google Scholar 

  • Enriquez-de-Salamanca A, Castellanos E, Stern ME, Fernandez I et al (2010) Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease. Mol Vis 16:862–873

    CAS  PubMed  PubMed Central  Google Scholar 

  • Epitropoulos AT, Donnenfeld ED, Shah ZA, Holland EJ et al (2016) Effect of oral re-esterified omega-3 nutritional supplementation on dry eyes. Cornea 35:1185–1191

    PubMed  PubMed Central  Google Scholar 

  • Esmaeelpour M, Watts PO, Boulton ME, Cai J, Murphy PJ (2011) Tear film volume and protein analysis in full-term newborn infants. Cornea 30:400–404

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Esmaeli B (2005) Management of excessive tearing as a side effect of docetaxel. Clin Breast Cancer 5:455–457

    CAS  PubMed  Google Scholar 

  • Esmaeli B, Ahmadi MA, Rivera E, Valero V et al (2002) Docetaxel secretion in tears: association with lacrimal drainage obstruction. Arch Ophthalmol 120:1180–1182

    CAS  PubMed  Google Scholar 

  • Evans KS, North RV, Purslow C (2009) Tear ferning in contact lens wearers. Ophthalmic Physiol Opt 29:199–204

    Article  PubMed  Google Scholar 

  • Fariselli C, Giannaccare G, Fresina M, Versura P (2018) Trehalose/hyaluronate eyedrop effects on ocular surface inflammatory markers and mucin expression in dry eye patients. Clin Ophthalmol 12:1293–1300

    PubMed  PubMed Central  Google Scholar 

  • Fenga C, Aragona P, Cacciola A, Spinella R et al (2008) Meibomian gland dysfunction and ocular discomfort in video display terminal workers. Eye (Lond) 22:91–95

    CAS  Google Scholar 

  • Fitzgerald-Hayes A, Reichsman F (2009) DNA and biotechnology. Academic, New York

    Google Scholar 

  • Flanagan JL, Willcox MD (2009) Role of lactoferrin in the tear film. Biochimie 91:35–43

    CAS  PubMed  Google Scholar 

  • Fodor M (2009) Doctoral school in clinical medicine. University of Debrecen, Debrecen

    Google Scholar 

  • Fuchigami A, Huang J, Nakajima K, Kozawa M et al (2015) Impact of a case series of corneal transplant rejection on the kinetics of cytokine concentrations in human tears after keratoplasty. Int J Ophthalmic Res 1:59–65

    Article  Google Scholar 

  • Fukuda M, Fullard RJ, Willcox MD, Baleriola-Lucas C et al (1996) Fibronectin in the tear film. Invest Ophthalmol Vis Sci 37:459–467

    CAS  PubMed  Google Scholar 

  • Fullard RJ, Snyder C (1990) Protein levels in nonstimulated and stimulated tears of normal human subjects. Invest Ophthalmol Vis Sci 31:1119–1126

    CAS  PubMed  Google Scholar 

  • Fust A, Veres A, Kiszel P, Nagy ZZ et al (2003) Changes in tear protein pattern after photorefractive keratectomy. Eur J Ophthalmol 13:525–531

    CAS  PubMed  Google Scholar 

  • Gad A, Vingrys AJ, Wong CY, Jackson DC, Downie LE (2018) Tear film inflammatory cytokine upregulation in contact lens discomfort. Ocul Surf. https://doi.org/10.1016/j.jtos.2018.10.004

    Article  PubMed  Google Scholar 

  • Gagliano C, Caruso S, Napolitano G, Malaguarnera G et al (2014) Low levels of 17-beta-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study. Br J Ophthalmol 98:371–376

    Article  PubMed  Google Scholar 

  • Galbis-Estrada C, Pinazo-Duran MD, Martinez-Castillo S, Morales JM et al (2015) A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids. Mol Vis 21:555–567

    CAS  PubMed  PubMed Central  Google Scholar 

  • Garrett Q, Chatelier RC, Griesser HJ, Milthorpe BK (1998) Effect of charged groups on the adsorption and penetration of proteins onto and into carboxymethylated poly(HEMA) hydrogels. Biomaterials 19:2175–2186

    Article  CAS  PubMed  Google Scholar 

  • Gauba V, Curtis ZJ (2014) Sleep position and the ocular surface in a high airflow environment. Saudi J Ophthalmol 28:66–68

    PubMed  Google Scholar 

  • Gaudana R, Ananthula HK, Parenky A, Mitra AK (2010) Ocular drug delivery. AAPS J 12:348–360

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gayton JL (2009) Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol 3:405–412

    PubMed  PubMed Central  Google Scholar 

  • Geroski DH, Edelhauser HF (2000) Drug delivery for posterior segment eye disease. Invest Ophthalmol Vis Sci 41:961–964

    CAS  PubMed  Google Scholar 

  • Giannaccare G, Blalock W, Fresina M, Vagge A, Versura P (2016) Intolerant contact lens wearers exhibit ocular surface impairment despite 3 months wear discontinuation. Graefes Arch Clin Exp Ophthalmol 254:1825–1831

    Article  PubMed  Google Scholar 

  • Gipson IK, Spurr-Michaud SJ, Senchyna M, Ritter R 3rd, Schaumberg D (2011) Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye. Cornea 30:1346–1352

    Article  PubMed  PubMed Central  Google Scholar 

  • Girard B, Piaton JM, Keller P, Nguyen TH (2018) Botulinum neurotoxin A injection for the treatment of epiphora with patent lacrymal ducts. J Fr Ophtalmol 41:343–349

    CAS  PubMed  Google Scholar 

  • Glasgow BJ, Gasymov OK (2011) Focus on molecules: tear lipocalin. Exp Eye Res 92:242–243

    CAS  PubMed  Google Scholar 

  • Glasson M, Stapleton F, Willcox M (2002) Lipid, lipase and lipocalin differences between tolerant and intolerant contact lens wearers. Curr Eye Res 25:227–235

    Article  CAS  PubMed  Google Scholar 

  • Glasson MJ, Stapleton F, Keay L, Sweeney D, Willcox MD (2003) Differences in clinical parameters and tear film of tolerant and intolerant contact lens wearers. Invest Ophthalmol Vis Sci 44:5116–5124

    Article  PubMed  Google Scholar 

  • Grube M, Holler E, Weber D, Holler B et al (2016) Risk factors and outcome of chronic graft-versus-host disease after allogeneic stem cell transplantation-results from a single-center observational study. Biol Blood Marrow Transplant 22:1781–1791

    PubMed  Google Scholar 

  • Grumetto L, Cennamo G, Del Prete A, La Rotonda MI, Barbato F (2002) Pharmacokinetics of cetirizine in tear fluid after a single oral dose. Clin Pharmacokinet 41:525–531

    CAS  PubMed  Google Scholar 

  • Guillon M, Maissa C (2008) Contact lens wear affects tear film evaporation. Eye Contact Lens 34:326–330

    Article  PubMed  Google Scholar 

  • Guillon M, Maissa C (2010) Tear film evaporation – effect of age and gender. Cont Lens Anterior Eye 33:171–175

    PubMed  Google Scholar 

  • Hahn SK, Keum DH (2016) Smart contact lens and smart eye glasses. Front Bioeng Biotechnol 4:454–461

    Google Scholar 

  • Hirayama M, Murat D, Liu Y, Kojima T et al (2013) Efficacy of a novel moist cool air device in office workers with dry eye disease. Acta Ophthalmol 91:756–762

    PubMed  Google Scholar 

  • Holopainen JM, Moilanen JA, Sorsa T, Kivela-Rajamaki M et al (2003) Activation of matrix metalloproteinase-8 by membrane type 1-MMP and their expression in human tears after photorefractive keratectomy. Invest Ophthalmol Vis Sci 44:2550–2556

    PubMed  Google Scholar 

  • Hori Y, Argueso P, Spurr-Michaud S, Gipson IK (2006) Mucins and contact lens wear. Cornea 25:176–181

    Article  PubMed  Google Scholar 

  • Horwitz BL, Christensen GR, Ritzmann SR (1978) Diurnal profiles of tear lysozyme and gamma A globulin. Ann Ophthalmol 10:75–80

    CAS  PubMed  Google Scholar 

  • Hume EB, Cole N, Parmar A, Tan ME et al (2004) Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion. Invest Ophthalmol Vis Sci 45:3161–3164

    Article  PubMed  Google Scholar 

  • Huth SW, Miller MJ, Leopold IH (1981) Calcium and protein in tears: diurnal variation. Arch Ophthalmol 99:1628–1633

    CAS  PubMed  Google Scholar 

  • Iannella G, Di Nardo G, Plateroti R, Rossi P et al (2015) Investigation of pepsin in tears of children with laryngopharyngeal reflux disease. Int J Pediatr Otorhinolaryngol 79:2312–2315

    Article  PubMed  Google Scholar 

  • Idu FK, Emina MO, Ubaru CO (2013) Tear secretion and tear stability of women on hormonal contraceptives. J Optom 6:45–50

    Google Scholar 

  • Isenberg SJ, Del Signore M, Chen A, Wei J, Guillon JP (2003) The lipid layer and stability of the preocular tear film in newborns and infants. Ophthalmology 110:1408–1411

    Article  PubMed  Google Scholar 

  • Jee D, Park SH, Kim MS, Kim EC (2014) Antioxidant and inflammatory cytokine in tears of patients with dry eye syndrome treated with preservative-free versus preserved eye drops. Invest Ophthalmol Vis Sci 55:5081–5089

    Article  PubMed  Google Scholar 

  • Jensen OL, Gluud BS, Eriksen HO (1985a) Fibronectin in tears following surgical trauma to the eye. Acta Ophthalmol (Copenh) 63:346–350

    CAS  Google Scholar 

  • Jensen OL, Gluud BS, Eriksen HO, Birgens HS (1985b) In: Peeters H (ed) Protides of the biological fluids. Elsevier, Amsterdam, pp 157–160

    Google Scholar 

  • Jiang N, Montelongo Y, Butt H, Yetisen AK (2018) Microfluidic Contact Lenses. Small 14:e1704363

    Article  PubMed  Google Scholar 

  • Jung JW, Han SJ, Nam SM, Kim TI et al (2016) Meibomian gland dysfunction and tear cytokines after cataract surgery according to preoperative meibomian gland status. Clin Exp Ophthalmol 44:555–562

    PubMed  Google Scholar 

  • Kangari H, Eftekhari MH, Sardari S, Hashemi H et al (2013) Short-term consumption of oral omega-3 and dry eye syndrome. Ophthalmology 120:2191–2196

    PubMed  Google Scholar 

  • Karamitsos A, Kokkas V, Goulas A, Paraskevopoulos P et al (2013) Ocular surface and tear film abnormalities in women under adjuvant chemotherapy for breast cancer with the 5-Fluorouracil, Epirubicin and Cyclophosphamide (FEC) regimen. Hippokratia 17:120–125

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kawai S, Nakajima T, Hokari S, Komoda T, Kawai K (2002) Apolipoprotein A-I concentration in tears in diabetic retinopathy. Ann Clin Biochem 39:56–61

    CAS  PubMed  Google Scholar 

  • Kerimoglu H, Ozturk B, Gunduz K, Bozkurt B et al (2010) Effect of altered eating habits and periods during Ramadan fasting on intraocular pressure, tear secretion, corneal and anterior chamber parameters. Eye (Lond) 24:97–100

    CAS  Google Scholar 

  • Khaksari M, Mazzoleni LR, Ruan C, Kennedy RT, Minerick AR (2017) Determination of water-soluble and fat-soluble vitamins in tears and blood serum of infants and parents by liquid chromatography/mass spectrometry. Exp Eye Res 155:54–63

    Article  CAS  PubMed  Google Scholar 

  • Khalil HE, Aboud S, Azzab M (2018) Comparative study between smokers and nonsmokers regarding dry eye. Delta J Ophthalmol 19:9–13

    Google Scholar 

  • Kim JH, Kim JH, Nam WH, Yi K et al (2012) Oral alcohol administration disturbs tear film and ocular surface. Ophthalmology 119:965–971

    PubMed  Google Scholar 

  • Kim N, Kim JW, Baek JH, Kim JS et al (2018) S-1-induced lacrimal drainage obstruction and its association with ingredients/metabolites of S-1 in tears and plasma: a prospective multi-institutional study. Cancer Res Treat 50:30–39

    CAS  PubMed  Google Scholar 

  • Kishazi E, Dor M, Eperon S, Oberic A et al (2018) Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy. Sci Rep 8:10792

    PubMed  PubMed Central  Google Scholar 

  • Komatsu H, Inui A, Sogo T, Tateno A et al (2012) Tears from children with chronic hepatitis B virus (HBV) infection are infectious vehicles of HBV transmission: experimental transmission of HBV by tears, using mice with chimeric human livers. J Infect Dis 206:478–485

    Article  CAS  PubMed  Google Scholar 

  • Kramann C, Boehm N, Lorenz K, Wehrwein N et al (2011) Effect of contact lenses on the protein composition in tear film: a ProteinChip study. Graefes Arch Clin Exp Ophthalmol 249:233–243

    Article  PubMed  Google Scholar 

  • Kumar R, Parmar IP, Chhillar N, Lal H (1997) Tear lactoferrin concentration during postoperative ocular inflammation in cataract surgery. Acta Ophthalmol Scand 75:142–144

    CAS  PubMed  Google Scholar 

  • Kumar G, Swarna S, Mahadevan R (2017) The ocular surface and lens comfort. Contact Lens Spectrum 32:38–39

    Google Scholar 

  • Kurtul BE, Ozer PA, Aydinli MS (2015) The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjogren dry eye. Eye (Lond) 29:1081–1084

    CAS  Google Scholar 

  • Kuscu NK, Toprak AB, Vatansever S, Koyuncu FM, Guler C (2003) Tear function changes of postmenopausal women in response to hormone replacement therapy. Maturitas 44:63–68

    Article  CAS  PubMed  Google Scholar 

  • Kyrmizakis DE, Pangalos A, Papadakis CE, Logothetis J et al (2004) The use of botulinum toxin type A in the treatment of Frey and crocodile tears syndromes. J Oral Maxillofac Surg 62:840–844

    PubMed  Google Scholar 

  • Lam SM, Tong L, Reux B, Duan X et al (2014b) Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. J Lipid Res 55:299–306

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lam-Franco L, Perfecto-Avalos Y, Patino-Ramirez BE, Rodriguez Garcia A (2018) IL-1alpha and MMP-9 tear levels of patients with active ocular rosacea before and after treatment with systemic azithromycin or doxycycline. Ophthalmic Res 60:109–114

    CAS  PubMed  Google Scholar 

  • Lane JD, Krumholz DM, Sack RA, Morris C (2006) Tear glucose dynamics in diabetes mellitus. Curr Eye Res 31:895–901

    CAS  PubMed  Google Scholar 

  • Lawrenson JG, Murphy PJ, Esmaeelpour M (2003) The neonatal tear film. Cont Lens Anterior Eye 26:197–202

    Article  PubMed  Google Scholar 

  • Lee JB, Ryu CH, Kim J, Kim EK, Kim HB (2000) Comparison of tear secretion and tear film instability after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg 26:1326–1331

    CAS  PubMed  Google Scholar 

  • Lee YB, Koh JW, Hyon JY, Wee WR et al (2014) Sleep deprivation reduces tear secretion and impairs the tear film. Invest Ophthalmol Vis Sci 55:3525–3531

    PubMed  Google Scholar 

  • Leonardi A, Abelson MB (2003) Double-masked, randomized, placebo-controlled clinical study of the mast cell-stabilizing effects of treatment with olopatadine in the conjunctival allergen challenge model in humans. Clin Ther 25:2539–2552

    CAS  PubMed  Google Scholar 

  • Lifshitz M, Weinstein O, Gavrilov V, Rosenthal G, Lifshitz T (1999) Acetaminophen (paracetamol) levels in human tears. Ther Drug Monit 21:544–546

    CAS  PubMed  Google Scholar 

  • Liu J, Shi B, He S, Yao X et al (2010a) Changes to tear cytokines of type 2 diabetic patients with or without retinopathy. Mol Vis 16:2931–2938

    CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Q, Liu J, Ren C, Cai W et al (2017) Proteomic analysis of tears following acupuncture treatment for menopausal dry eye disease by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry. Int J Nanomedicine 12:1663–1671

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lopez-Miguel A, Teson M, Martin-Montanez V, Enriquez-de-Salamanca A et al (2014) Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions. Am J Ophthalmol 157:788–798 e782

    PubMed  Google Scholar 

  • Lopez-Miguel A, Teson M, Martin-Montanez V, Enriquez-de-Salamanca A et al (2016) Clinical and molecular inflammatory response in sjogren syndrome-associated dry eye patients under desiccating stress. Am J Ophthalmol 161:133–141. e131-132

    CAS  PubMed  Google Scholar 

  • Loprinzi CL, Love RR, Garrity JA, Ames MM (1990) Cyclophosphamide, methotrexate, and 5-fluorouracil (CMF)-induced ocular toxicity. Cancer Invest 8:459–465

    CAS  PubMed  Google Scholar 

  • Luensmann D, Jones L (2008) Albumin adsorption to contact lens materials: a review. Cont Lens Anterior Eye 31:179–187

    Article  PubMed  Google Scholar 

  • Luensmann D, Jones L (2012) Protein deposition on contact lenses: the past, the present, and the future. Cont Lens Anterior Eye 35:53–64

    PubMed  Google Scholar 

  • Luevano-Contreras C, Chapman-Novakofski K (2010) Dietary advanced glycation end products and aging. Nutrients 2:1247–1265

    CAS  PubMed  PubMed Central  Google Scholar 

  • Madej KA (2010) Analysis of meconium, nails and tears for determination of medicines and drugs of abuse. Trends Analy Chem 29:246–259

    Article  CAS  Google Scholar 

  • Makateb A, Torabifard H (2017) Dry eye signs and symptoms in night-time workers. J Curr Ophthalmol 29:270–273

    PubMed  PubMed Central  Google Scholar 

  • Mann A, Tighe B (2013) Contact lens interactions with the tear film. Exp Eye Res 117:88–98

    Article  CAS  PubMed  Google Scholar 

  • Mantelli F, Tiberi E, Micera A, Lambiase A et al (2007) MUC5AC overexpression in tear film of neonates. Graefes Arch Clin Exp Ophthalmol 245:1377–1381

    Article  CAS  PubMed  Google Scholar 

  • Mantelli F, Lambiase A, Sacchetti M, Orlandi V et al (2015) Cocaine snorting may induce ocular surface damage through corneal sensitivity impairment. Graefes Arch Clin Exp Ophthalmol 253:765–772

    CAS  PubMed  Google Scholar 

  • Markoulli M, Papas E, Cole N, Holden BA (2012) The diurnal variation of matrix metalloproteinase-9 and its associated factors in human tears. Invest Ophthalmol Vis Sci 53:1479–1484

    Article  CAS  PubMed  Google Scholar 

  • Martin XD, Brennan MC (1994) Serotonin in human tears. Eur J Ophthalmol 4:159–165

    CAS  PubMed  Google Scholar 

  • Martinez R, Acera A, Soria J, Gonzalez N, Suarez T (2011) Allergic mediators in tear from children with seasonal and perennial allergic conjunctivitis. Arch Soc Esp Oftalmol 86:187–192

    CAS  PubMed  Google Scholar 

  • Martin-Montanez V, Enriquez-de-Salamanca A, Lopez-de la Rosa A, Lopez-Miguel A et al (2016) Effect of environmental conditions on the concentration of tear inflammatory mediators during contact lens wear. Cornea 35:1192–1198

    PubMed  Google Scholar 

  • Masmali AM, Al-Bahlal JM, El-Hiti GA, Akhtar S et al (2015b) Repeatability and diurnal variation of tear ferning test. Eye Contact Lens 41:262–267

    PubMed  Google Scholar 

  • Masmali AM, Al-Shehri A, Alanazi SA, Abusharaha A et al (2016) Assessment of tear film quality among smokers using tear ferning patterns. J Ophthalmol 2016:8154315

    PubMed  PubMed Central  Google Scholar 

  • Masoudi S, Stapleton FJ, Willcox MD (2016) Contact lens-induced discomfort and protein changes in tears. Optom Vis Sci 93:955–962

    Article  PubMed  Google Scholar 

  • Matsumoto Y, Dogru M, Goto E, Sasaki Y et al (2008) Alterations of the tear film and ocular surface health in chronic smokers. Eye (Lond) 22:961–968

    CAS  Google Scholar 

  • Maurya RP, Bhushan P, Singh VP, Singh MK et al (2014) Immunoglobulin concentration in tears of contact lens wearers. J Ophthalmic Vis Res 9:320–323

    PubMed  PubMed Central  Google Scholar 

  • McDermott AM (2004) Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf 2:229–247

    PubMed  PubMed Central  Google Scholar 

  • McGill JI, Liakos GM, Goulding N, Seal DV (1984) Normal tear protein profiles and age-related changes. Br J Ophthalmol 68:316–320

    CAS  PubMed  PubMed Central  Google Scholar 

  • McMurray DN, Rey H, Casazza LJ, Watson RR (1977) Effect of moderate malnutrition on concentrations of immunoglobulins and enzymes in tears and saliva of young Colombian children. Am J Clin Nutr 30:1944–1948

    CAS  PubMed  Google Scholar 

  • Megwas WA, Izuawuba MA (2008) The effect of acetaminophen (Paracetamol) on tear production. J Nigerian Opt Assoc 14:27–29

    Google Scholar 

  • Micera A, Di Zazzo A, Esposito G, Longo R et al (2018) Age-related changes to human tear composition. Invest Ophthalmol Vis Sci 59:2024–2031

    CAS  PubMed  Google Scholar 

  • Modi P, Arsiwalla T (2018) StatPearls. StatPearls Publishing, Treasure Island

    Google Scholar 

  • Monaco F, Piredda S, Mutani R, Mastropaolo C, Tondi M (1982) The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid. Epilepsia 23:23–26

    CAS  PubMed  Google Scholar 

  • Mora P, Ceglarek U, Manzotti F, Zavota L et al (2008) Cyclosporin A in the ocular fluids of uveitis patients following long-term systemic administration. Graefes Arch Clin Exp Ophthalmol 246:1047–1052

    CAS  PubMed  Google Scholar 

  • Moshirfar M, Pierson K, Hanamaikai K, Santiago-Caban L et al (2014) Artificial tears potpourri: a literature review. Clin Ophthalmol 8:1419–1433

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mucci LA, Hjelmborg JB, Harris JR, Czene K et al (2016) Familial risk and heritability of cancer among twins in Nordic countries. JAMA 315:68–76

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muntz A, Subbaraman LN, Sorbara L, Jones L (2015) Tear exchange and contact lenses: a review. J Optom 8:2–11

    Article  PubMed  PubMed Central  Google Scholar 

  • Murube J (2008) REM sleep: tear secretion and dreams. Ocul Surf 6:2–8

    PubMed  Google Scholar 

  • Nair S, Vanathi M, Mahapatra M, Seth T et al (2018) Tear inflammatory mediators and protein in eyes of post allogenic hematopoeitic stem cell transplant patients. Ocul Surf 16:352–367

    PubMed  Google Scholar 

  • Navascues-Cornago M, Morgan PB, Maldonado-Codina C (2015) Effect of three interventions on contact lens comfort in symptomatic wearers: a randomized clinical trial. PLoS One 10:e0135323

    Article  PubMed  PubMed Central  Google Scholar 

  • Nejima R, Miyata K, Tanabe T, Okamoto F et al (2005) Corneal barrier function, tear film stability, and corneal sensation after photorefractive keratectomy and laser in situ keratomileusis. Am J Ophthalmol 139:64–71

    PubMed  Google Scholar 

  • Nemet AY (2016) The etiology of epiphora: a multifactorial issue. Semin Ophthalmol 31:275–279

    PubMed  Google Scholar 

  • Norn M (1985) The effects of drugs on tear flow. Trans Ophthalmol Soc U K 104(Pt 4):410–414

    PubMed  Google Scholar 

  • Oh JW, Shin JC, Jang SJ, Lee HB (1999) Expression of ICAM-1 on conjunctival epithelium and ECP in tears and serum from children with allergic conjunctivitis. Ann Allergy Asthma Immunol 82:579–585

    CAS  PubMed  Google Scholar 

  • Okada E, Matsuda T, Yokoyama T, Okuda K (2006) Lysozyme penetration in group IV soft contact lenses. Eye Contact Lens 32:174–177

    Article  PubMed  Google Scholar 

  • Omali NB, Subbaraman LN, Coles-Brennan C, Fadli Z, Jones LW (2015) Biological and clinical implications of lysozyme deposition on soft contact lenses. Optom Vis Sci 92:750–757

    PubMed  PubMed Central  Google Scholar 

  • Osei KA, Ovenseri-Ogbomo G, Kyei S, Ntodie M (2014) The effect of caffeine on tear secretion. Optom Vis Sci 91:171–177

    PubMed  Google Scholar 

  • Otto CS, McMann MA, Parmley VC, Dahlhauser KF et al (2002) Warm balanced salt solution for clearing tear film precipitation during cataract surgery. J Cataract Refract Surg 28:1318–1319

    PubMed  Google Scholar 

  • Park S, Lee DY (2018) Materials and applications of smart diagnostic contact lens systems. Adv Exp Med Biol 1078:155–160

    Article  PubMed  Google Scholar 

  • Pastori V, Tavazzi S, Lecchi M (2015) Lactoferrin-loaded contact lenses: eye protection against oxidative stress. Cornea 34:693–697

    Article  PubMed  Google Scholar 

  • Patel S, Perez-Santonja JJ, Alio JL, Murphy PJ (2001) Corneal sensitivity and some properties of the tear film after laser in situ keratomileusis. J Refract Surg 17:17–24

    CAS  PubMed  Google Scholar 

  • Peponis V, Papathanasiou M, Kapranou A, Magkou C et al (2002) Protective role of oral antioxidant supplementation in ocular surface of diabetic patients. Br J Ophthalmol 86:1369–1373

    CAS  PubMed  PubMed Central  Google Scholar 

  • Phan CM, Walther H, Gao H, Rossy J et al (2016) Development of an In vitro ocular platform to test contact lenses. J Vis Exp 110:e53907

    Google Scholar 

  • Pinazo-Duran MD, Galbis-Estrada C, Pons-Vazquez S, Cantu-Dibildox J et al (2013) Effects of a nutraceutical formulation based on the combination of antioxidants and omega-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders. Clin Interv Aging 8:139–148

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Postnikoff CK, Nichols KK (2017) Neutrophil and T-cell homeostasis in the closed eye. Invest Ophthalmol Vis Sci 58:6212–6220

    CAS  PubMed  PubMed Central  Google Scholar 

  • Postnikoff CK, Huisingh C, McGwin G, Nichols KK (2018) Leukocyte distribution in the open eye tears of normal and dry eye subjects. Curr Eye Res 43(10):1253–1259

    CAS  PubMed  PubMed Central  Google Scholar 

  • Provine RR (2012) Curious behavior. Belknap Press of Harvard University Press, Cambridge, MA

    Book  Google Scholar 

  • Pucker AD, Ng SM, Nichols JJ (2016) Over the counter (OTC) artificial tear drops for dry eye syndrome. Cochrane Database Syst Rev 2:CD009729

    PubMed  Google Scholar 

  • Puinhas A, Sampaio P, Castanheira EM, Real Oliveira ME, Lira M (2013) Comparison of IgA, TNF-alpha and surface tension of the tear film in two different times of the day. Cont Lens Anterior Eye 36:140–145

    PubMed  Google Scholar 

  • Raines DA, Yusuf A, Jabak MH, Ahmed WS et al (1998) Simultaneous high-performance liquid chromatography analysis of azithromycin and two of its metabolites in human tears and plasma. Ther Drug Monit 20:680–684

    CAS  PubMed  Google Scholar 

  • Rathi S, Jalali S, Patnaik S, Shahulhameed S et al (2017) Abnormal complement activation and inflammation in the pathogenesis of retinopathy of prematurity. Front Immunol 8:1868

    Article  PubMed  PubMed Central  Google Scholar 

  • Ravazzoni L, Ghini C, Macri A, Rolando M (1998) Forecasting of hydrophilic contact lens tolerance by means of tear ferning test. Graefes Arch Clin Exp Ophthalmol 236:354–358

    Article  CAS  PubMed  Google Scholar 

  • Rees LW, Munn AD, Maddock J, Robinson PR (2000) The rapid determination of tobramycin in microlitre quantities of human tear fluid using LC-MS-MS. Chromatographia 52:S98–S100

    CAS  Google Scholar 

  • Renom G, Bouquety JC, Lanckriet C, Georges AJ et al (1990) HIV-specific IgA antibodies in tears of children with AIDS or at risk of AIDS. Res Virol 141:355–363

    Article  CAS  PubMed  Google Scholar 

  • Resan M, Stanojevic I, Petkovic A, Pajic B, Vojvodic D (2015) Levels of interleukin-6 in tears before and after excimer laser treatment. Vojnosanit Pregl 72:350–355

    PubMed  Google Scholar 

  • Riem MME, van IMH, De Carli P, Vingerhoets A, Bakermans-Kranenburg MJ (2017) As tears go by: baby tears trigger more brain activity than adult tears in nulliparous women. Soc Neurosci 12:633–636

    CAS  PubMed  Google Scholar 

  • Riemens A, Stoyanova E, Rothova A, Kuiper J (2012) Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation. Mol Vis 18:797–802

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rocha EM, Alves M, Rios JD, Dartt DA (2008) The aging lacrimal gland: changes in structure and function. Ocul Surf 6:162–174

    PubMed  PubMed Central  Google Scholar 

  • Rohit A, Willcox M, Stapleton F (2013a) Tear lipid layer and contact lens comfort: a review. Eye Contact Lens 39:247–253

    PubMed  Google Scholar 

  • Rohit A, Brown S, Willcox M, Stapleton F (2013b) The effect of tear lipid biochemistry on tear evaporation rate during contact lens wear. Invest Ophth Vis Sci 54:4358–4358

    Article  Google Scholar 

  • Rohit A, Willcox MD, Brown SH, Mitchell TW, Stapleton F (2014b) Clinical and biochemical tear lipid parameters in contact lens wearers. Optom Vis Sci 91:1384–1390

    PubMed  Google Scholar 

  • Rummenie VT, Matsumoto Y, Dogru M, Wang Y et al (2008) Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure. Cytokine 43:200–208

    CAS  PubMed  Google Scholar 

  • Runstrom G, Mann A, Tighe B (2013) The fall and rise of tear albumin levels: a multifactorial phenomenon. Ocul Surf 11:165–180

    PubMed  Google Scholar 

  • Rusciano D, Pezzino S, Olivieri M, Cristaldi M et al (2018) Age-related dry eye lactoferrin and lactobionic acid. Ophthalmic Res 60:1–6

    Google Scholar 

  • Saari KM, Aine E, Posz A, Klockars M (1983) Lysozyme content of tears in normal subjects and in patients with external eye infections. Graefes Arch Clin Exp Ophthalmol 221:86–88

    CAS  PubMed  Google Scholar 

  • Saari KM, Aho V, Paavilainen V, Nevalainen TJ (2001) Group II PLA(2) content of tears in normal subjects. Invest Ophthalmol Vis Sci 42:318–320

    CAS  PubMed  Google Scholar 

  • Sack RA, Tan KO, Tan A (1992) Diurnal tear cycle: evidence for a nocturnal inflammatory constitutive tear fluid. Invest Ophthalmol Vis Sci 33:626–640

    CAS  PubMed  Google Scholar 

  • Safarzadeh M, Azizzadeh P, Akbarshahi P (2017) Comparison of the clinical efficacy of preserved and preservative-free hydroxypropyl methylcellulose-dextran-containing eyedrops. J Optom 10:258–264

    Article  PubMed  Google Scholar 

  • Saijyothi AV, Fowjana J, Madhumathi S, Rajeshwari M et al (2012) Tear fluid small molecular antioxidants profiling shows lowered glutathione in keratoconus. Exp Eye Res 103:41–46

    CAS  PubMed  Google Scholar 

  • Sand BB, Jensen OL, Eriksen JS, Vinding T (1986) Lysozyme in tears during post-operative inflammation of the eye. Acta Ophthalmol (Copenh) 64:504–508

    CAS  Google Scholar 

  • Sano K, Kawashima M, Ikeura K, Arita R, Tsubota K (2015) Abdominal breathing increases tear secretion in healthy women. Ocul Surf 13:82–87

    PubMed  Google Scholar 

  • Sariri R, Arasteh A, Mahmoodian J (2006) Heavy smoking and tears protein pattern. Asian J Chem 18:8–14

    CAS  Google Scholar 

  • Sariri R, Varasteh A, Sajedi RH (2010) Effect of Ramadan fasting on tear proteins. Acta Medica (Hradec Kralove) 53:147–151

    Article  CAS  Google Scholar 

  • Satici A, Bitiren M, Ozardali I, Vural H et al (2003) The effects of chronic smoking on the ocular surface and tear characteristics: a clinical, histological and biochemical study. Acta Ophthalmol Scand 81:583–587

    PubMed  Google Scholar 

  • Sayin N, Kara N, Pekel G, Altinkaynak H (2014) Effects of chronic smoking on central corneal thickness, endothelial cell, and dry eye parameters. Cutan Ocul Toxicol 33:201–205

    CAS  PubMed  Google Scholar 

  • Schultz CL, Kunert KS (2000) Interleukin-6 levels in tears of contact lens wearers. J Interferon Cytokine Res 20:309–310

    Article  CAS  PubMed  Google Scholar 

  • Scuderi G, Contestabile MT, Gagliano C, Iacovello D et al (2012) Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial. Can J Ophthalmol 47:489–492

    PubMed  Google Scholar 

  • Semeraro F, Costagliola C, Cancarini A, Gilberti E et al (2012) Defining reference values of trace elements in the tear film: diagnostic methods and possible applications. Ecotoxicol Environ Saf 80:190–194

    Article  CAS  PubMed  Google Scholar 

  • Service RF (2018) Science

    Google Scholar 

  • Sharanjeet-Kaur, Ho CY, Mutalib HA, Ghazali AR (2016) The relationship between tear ferning patterns and non-invasive tear break-up time in normal Asian population. J Optom 9:175–181

    Article  CAS  PubMed  Google Scholar 

  • Shetty R, Ghosh A, Lim RR, Subramani M et al (2015) Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci 56:738–750

    CAS  PubMed  Google Scholar 

  • Shigeyasu C, Yamada M, Akune Y (2016) Influence of ophthalmic solutions on tear components. Cornea 35(Suppl 1):S71–S77

    PubMed  Google Scholar 

  • Shimazaki J, Shimmura S, Fujishima H, Tsubota K (2000) Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome. Ophthalmology 107:1518–1523

    CAS  PubMed  Google Scholar 

  • Shiuey Y, Ambati BK, Adamis AP (2000) A randomized, double-masked trial of topical ketorolac versus artificial tears for treatment of viral conjunctivitis. Ophthalmology 107:1512–1517

    Article  CAS  PubMed  Google Scholar 

  • Shoji J, Aso H, Inada N (2017) Clinical Usefulness of Simultaneous Measurement of the Tear Levels of CCL17, CCL24, and IL-16 for the Biomarkers of Allergic Conjunctival Disorders. Curr Eye Res 42:677–684

    CAS  PubMed  Google Scholar 

  • Shrestha GS, Sujakhu D, Shrestha JB, Shrestha JK (2012) Tear film evaluation in contact lens wearers and non wearers. J Inst Med 34:14–20

    Google Scholar 

  • Shuaibu AO, Agoreyo F (2016) Tear production in premenopausal women during menstrual cycle. Zimbabwe J Sci Technol 11:126–131

    Google Scholar 

  • Siddireddy JS, Vijay AK, Tan J, Willcox M (2018) The eyelids and tear film in contact lens discomfort. Cont Lens Anterior Eye 41:144–153

    Article  PubMed  Google Scholar 

  • Siganos DS, Popescu CN, Siganos CS, Pistola G (2000) Tear secretion following spherical and astigmatic excimer laser photorefractive keratectomy. J Cataract Refract Surg 26:1585–1589

    CAS  PubMed  Google Scholar 

  • Singh AK, Nagpal S, Tyagi R (2018) A study of tear ferning patterns in elderly individuals with dry eye disorder. J Clin Diagn Res 12:NC01–NC04

    Google Scholar 

  • Srinivasan S, Joyce E, Jones LW (2007) Tear osmolality and ferning patterns in postmenopausal women. Optom Vis Sci 84:588–592

    Article  PubMed  Google Scholar 

  • Su SB, Lu CW, Sheen JW, Kuo SC, Guo HR (2006) Tear secretion dysfunction among women workers engaged in light-on tests in the TFT-LCD industry. BMC Public Health 6:303

    PubMed  PubMed Central  Google Scholar 

  • Symeonidis C, Papakonstantinou E, Galli A, Tsinopoulos I et al (2013) Matrix metalloproteinase (MMP-2, -9) and tissue inhibitor (TIMP-1, -2) activity in tear samples of pediatric type 1 diabetic patients. Graefe’s Arch Clin Exp Ophthalmol 251:741–749

    Article  CAS  Google Scholar 

  • Tabbara KF (2001) Tear tryptase in vernal keratoconjunctivitis. Arch Ophthalmol 119:338–342

    CAS  PubMed  Google Scholar 

  • Tan KO, Sack RA, Holden BA, Swarbrick HA (1993) Temporal sequence of changes in tear film composition during sleep. Curr Eye Res 12:1001–1007

    CAS  PubMed  Google Scholar 

  • Tatlipinar S, Gedik S, Irkec M, Orhan M, Erdener U (2001) Ocular ferning during the menstrual cycle in healthy women. Eur J Ophthalmol 11:15–18

    Article  CAS  PubMed  Google Scholar 

  • Tauste A, Ronda E, Baste V, Bratveit M et al (2018) Ocular surface and tear film status among contact lens wearers and non-wearers who use VDT at work: comparing three different lens types. Int Arch Occup Environ Health 91:327–335

    CAS  PubMed  Google Scholar 

  • Teson M, Gonzalez-Garcia MJ, Lopez-Miguel A, Enriquez-de-Salamanca A et al (2013) Influence of a controlled environment simulating an in-flight airplane cabin on dry eye disease. Invest Ophthalmol Vis Sci 54:2093–2099

    PubMed  Google Scholar 

  • Thakur A, Willcox MD, Stapleton F (1998) The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: homeostatic mechanisms. J Clin Immunol 18:61–70

    CAS  PubMed  Google Scholar 

  • Thomas J, Jacob GP, Abraham L, Noushad B (2012) The effect of smoking on the ocular surface and the precorneal tear film. Australas Med J 5:221–226

    PubMed  PubMed Central  Google Scholar 

  • Tieppo A, Pate KM, Byrne ME (2012) In vitro controlled release of an anti-inflammatory from daily disposable therapeutic contact lenses under physiological ocular tear flow. Eur J Pharm Biopharm 81:170–177

    Article  CAS  PubMed  Google Scholar 

  • Toker E, Yenice O, Ogut MS, Akman I, Ozek E (2002) Tear production during the neonatal period. Am J Ophthalmol 133:746–749

    Article  PubMed  Google Scholar 

  • Tomlinson A, Cedarstaff TH (1992) Diurnal variation in human tear evaporation. J Br Contact Lens Assoc 15:77–79

    Google Scholar 

  • Tomlinson A, Giesbrecht C (1994) Effect of age on human tear film evaporation in normals. Adv Exp Med Biol 350:271–274

    CAS  PubMed  Google Scholar 

  • Tomlinson A, Pearce EI, Simmons PA, Blades K (2001) Effect of oral contraceptives on tear physiology. Ophthalmic Physiol Opt 21:9–16

    CAS  PubMed  Google Scholar 

  • Tong L, Htoon HM, Hou A, Acharya RU et al (2018) Acupuncture and herbal formulation compared with artificial tears alone: evaluation of dry eye symptoms and associated tests in randomised clinical trial. BMJ Open Ophthalmol 3:e000150

    PubMed  PubMed Central  Google Scholar 

  • Tsalic M, Gilboa M, Visel B, Miller B, Haim N (2006) Epiphora (excessive tearing) and other ocular manifestations related to weekly docetaxel: underestimated dose-limiting toxicity. Med Oncol 23:57–61

    CAS  PubMed  Google Scholar 

  • Uchino E, Sonoda S, Kinukawa N, Sakamoto T (2006) Alteration pattern of tear cytokines during the course of a day: diurnal rhythm analyzed by multicytokine assay. Cytokine 33:36–40

    CAS  PubMed  Google Scholar 

  • Uchino Y, Uchino M, Yokoi N, Dogru M et al (2014) Alteration of tear mucin 5AC in office workers using visual display terminals: the Osaka Study. JAMA Ophthalmol 132:985–992

    Article  PubMed  Google Scholar 

  • Uchino Y, Uchino M, Yokoi N, Dogru M et al (2016) Impact of cigarette smoking on tear function and correlation between conjunctival goblet cells and tear MUC5AC concentration in office workers. Sci Rep 6:27699

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ullah A, Badshah M, Jamil U (2015) An unusual case of bloody tears. Ann Indian Acad Neurol 18:351–352

    Article  PubMed  PubMed Central  Google Scholar 

  • Valentic JP, Leopold IH, Dea FJ (1980) Excretion of salicylic acid into tears following oral administration of aspirin. Ophthalmology 87:815–820

    CAS  PubMed  Google Scholar 

  • Van Haeringen NJ (1997) Aging and the lacrimal system. Br J Ophthalmol 81:824–826

    PubMed  Google Scholar 

  • Vardhan P, Dhiman KS (2014) Clinical study to assess the efficacy of Keshanjana and Netra Parisheka in the management of Shushkakshipaka (dry eye syndrome). Ayu 35:277–282

    PubMed  PubMed Central  Google Scholar 

  • Venkata SJ, Narayanasamy A, Srinivasan V, Iyer GK et al (2009) Tear ascorbic acid levels and the total antioxidant status in contact lens wearers: a pilot study. Indian J Ophthalmol 57:289–292

    PubMed  PubMed Central  Google Scholar 

  • Versura P, Fresina M, Campos EC (2007) Ocular surface changes over the menstrual cycle in women with and without dry eye. Gynecol Endocrinol 23:385–390

    Article  PubMed  Google Scholar 

  • Versura P, Bavelloni A, Grillini M, Fresina M, Campos EC (2013a) Diagnostic performance of a tear protein panel in early dry eye. Mol Vis 19:1247–1257

    PubMed  PubMed Central  Google Scholar 

  • Versura P, Piazzi M, Giannaccare G, Fresina M et al (2016) 8th international conference on the tear film & ocular surface: basic science and clinical relevance, Montpellier, France, p 119

    Google Scholar 

  • Virtanen T, Ylatupa S, Mertaniemi P, Partanen P et al (1995) Tear fluid cellular fibronectin levels after photorefractive keratectomy. J Refract Surg 11:106–112

    CAS  PubMed  Google Scholar 

  • Wang TJ, Wang IJ, Ho JD, Chou HC et al (2010) Comparison of the clinical effects of carbomer-based lipid-containing gel and hydroxypropyl-guar gel artificial tear formulations in patients with dry eye syndrome: a 4-week, prospective, open-label, randomized, parallel-group, noninferiority study. Clin Ther 32:44–52

    Article  PubMed  Google Scholar 

  • Ward SK, Dogru M, Wakamatsu T, Ibrahim O et al (2010) Passive cigarette smoke exposure and soft contact lens wear. Optom Vis Sci 87:367–372

    PubMed  Google Scholar 

  • Watson RR, McMurray DN, Martin P, Reyes MA (1985) Effect of age, malnutrition and renutrition on free secretory component and IgA in secretions. Am J Clin Nutr 42:281–288

    CAS  PubMed  Google Scholar 

  • Weaver J (2011) Women’s tears contain chemical cues. Nat News. https://doi.org/10.1038/news.2011.2

  • Wei Y, Gadaria-Rathod N, Epstein S, Asbell P (2013) Tear cytokine profile as a noninvasive biomarker of inflammation for ocular surface diseases: standard operating procedures. Invest Ophthalmol Vis Sci 54:8327–8336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Willcox MD (2017) Is there a role for inflammation in contact lens discomfort? Eye Contact Lens 43:5–16

    Article  PubMed  Google Scholar 

  • Willcox MD, Morris CA, Thakur A, Sack RA et al (1997) Complement and complement regulatory proteins in human tears. Invest Ophthalmol Vis Sci 38:1–8

    CAS  PubMed  Google Scholar 

  • Willcox MD, Zhao Z, Naduvilath T, de la Jara Lazon P (2015) Cytokine changes in tears and relationship to contact lens discomfort. Mol Vis 21:293–305

    CAS  PubMed  PubMed Central  Google Scholar 

  • Willson SA, Middleton PA (2008) Breast cancer in young identical twins. Breast Cancer Res 10:P43

    Article  PubMed Central  Google Scholar 

  • Wong TT, Zhou L, Li J, Tong L et al (2011) Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication. Invest Ophthalmol Vis Sci 52:7385–7391

    CAS  PubMed  Google Scholar 

  • Yamada M, Mochizuki H, Kawashima M, Hata S (2006) Phospholipids and their degrading enzyme in the tears of soft contact lens wearers. Cornea 25:S68–S72

    PubMed  Google Scholar 

  • Yang L, Yang Z, Yu H, Song H (2015) Acupuncture therapy is more effective than artificial tears for dry eye syndrome: evidence based on a meta-analysis. Evid Based Complement Alternat Med 2015:143858

    PubMed  PubMed Central  Google Scholar 

  • Yasueda S, Yamakawa K, Nakanishi Y, Kinoshita M, Kakehi K (2005) Decreased mucin concentrations in tear fluids of contact lens wearers. J Pharm Biomed Anal 39:187–195

    CAS  PubMed  Google Scholar 

  • Yildirim P, Garip Y, Karci AA, Guler T (2016) Dry eye in vitamin D deficiency: more than an incidental association. Int J Rheum Dis 19:49–54

    CAS  PubMed  Google Scholar 

  • You YS, Qu NB, Yu XN (2016b) Alcohol consumption and dry eye syndrome: a meta-analysis. Int J Ophthalmol 9:1487–1492

    PubMed  PubMed Central  Google Scholar 

  • Young WH, Hill RM (1973) Tear cholesterol levels and contact lens adaptation. Am J Optom Arch Am Acad Optom 50:12–16

    Article  CAS  PubMed  Google Scholar 

  • Zhang J, Hodge W, Hutnick C, Wang X (2011a) Noninvasive diagnostic devices for diabetes through measuring tear glucose. J Diabetes Sci Technol 5:166–172

    PubMed  PubMed Central  Google Scholar 

  • Zhao Z, Liu J, Shi B, He S et al (2010) Advanced glycation end product (AGE) modified proteins in tears of diabetic patients. Mol Vis 16:1576–1584

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou L, Huang LQ, Beuerman RW, Grigg ME et al (2004) Proteomic analysis of human tears: defensin expression after ocular surface surgery. J Proteome Res 3:410–416

    CAS  PubMed  Google Scholar 

  • Zwerling CS (2016) Forensic analysis of a contact lens in a murder case. J Forensic Sci 61:534–539

    Article  PubMed  Google Scholar 

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  1. Mumbai, India

    Anjali Prashar

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  1. Anjali Prashar
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Prashar, A. (2019). Hue and Cry. In: Shed Tears for Diagnostics. Springer, Singapore. https://doi.org/10.1007/978-981-13-7169-1_6

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