Abstract
Infectious etiology may play a role in cataract formation during embryogenesis [1, 2]. Toxoplasma, Rubella, Cytomegalovirus (CMV), Herpes Simplex virus (HSV), and others including syphilis commonly referred to as TORCH infections have been associated with congenital cataract formation especially in developing countries [3–5]. In addition to childhood cataract, ocular manifestations of TORCH infections include chorioretinitis, microphthalmos, keratitis, iridocyclitis, iris atrophy, glaucoma, optic neuritis, and retinitis [6].
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Matoba A. Ocular viral infections. Pediatr Infect Dis. 1984;3:358–68.
Cotlier E. Congenital varicella cataract. Am J Ophthalmol. 1978;86:627–9.
Mahalakshmi B, Therese KL, Devipriya U, Pushpalatha V, Margarita S, Madhavan HN. Infectious aetiology of congenital cataract based on TORCHES screening in a tertiary eye hospital in Chennai, Tamil Nadu, India. Indian J Med Res. 2010;131:559–64.
Raghu H, Subhan S, Jose RJ, Gangopadhyay N, Bhende J, Sharma S. Herpes simplex virus-1-associated congenital cataract. Am J Ophthalmol. 2004;138:313–4.
Madhavan HN. Laboratory investigations on viral and chlamydia trachomatis infections of the eye: Sankara Nethralaya experiences. Indian J Ophthalmol. 1999;47:241–6.
Mets MB. Eye manifestations of intrauterine infections. Ophthalmol Clin N Am. 2001;14:521–31.
Mahalakshmi B, Therese KL, Shyamala G, Devipriya U, Madhavan HN. Toxoplasma gondii detection by nested polymerase chain reaction in lens aspirate and peripheral blood leukocyte in congenital cataract patients - the first report from a tertiary eye hospital in India. Curr Rye Res. 2007;32:653–7.
Shyamala G, Sowmya P, Madhavan HN, Malathi J. Relative efficiency of polymerase chain reaction and enzyme-linked immunosorbant assay in determination of viral etiology in congenital cataract in infants. J Postgrad Med. 2008;54:17–20.
Lu B, Yang Y. Detection of TORCH pathogens in children with congenital cataracts. Exp Ther Med. 2016;12(2):1159–64.
Vutova K, Peicheva Z, Popova A, Markova V, Mincheva N, Todorov T. Congenital toxoplasmosis: eye manifestations in infants and children. Ann Trop Paediatr. 2002;22:213–8.
Datta S, Banerjee DP. Chorioretinitis in congenital toxoplasmosis. Indian Pediatr. 2003;40:790–1.
Mittal V, Bhatia R, Singh VK, Sengal S. Low incidence of congenital toxoplasmosis in Indian children. J Trop Pediatr. 1995;41:62–3.
O’Neill JF. The ocular manifestations of congenital infection: a study of the early effect and long-term outcome of maternally transmitted rubella and toxoplasmosis. Trans Am Ophthalmol Soc. 1998;96:813–79.
Boniuk I. The cytomegalovirus and the eye. Int Ophthalmol Clin. 1972;12:169–90.
Tarkkanen A, Merenmies L, Holmstrom T. Ocular involvement in congenital cytomegalic inclusion disease. J Pediatr Ophthalmol. 1972;9:82–6.
Hittner HM, Desmond MM, Montgomery JR. Optic nerve manifestations of human congenital cytomegalovirus infection. Am J Ophthalmol. 1976;81:661–5.
Gregg NM. Congenital cataract following German measles in the mother. Trans Ophthalmol Soc Aust. 1941;3:35–46.
Papania MJ, Wallace GS, Rota PA, Icenogle JP, Fiebelkorn AP, Armstrong GL, Reef SE, Redd SB, Abernathy ES, Barskey AE, Hao L, McLean HQ, Rota JS, Bellini WJ, Seward JF. Elimination of endemic measles, rubella, and congenital rubella syndrome from the Western hemisphere; the US experience. JAMA Pediatr. 2014;168:148–55.
Sheridan E, Aitken C, Jeffries D, Hird M, Thayalasekaran P. Congenital rubella syndrome: a risk in immigrant populations. Lancet. 2002;359:674–5.
World Health Organization. Surveillance guidelines for measles, rubella and congenital rubella syndrome in the WHO European Region. http://www.euro.who.int/__data/assets/pdf_file/0018/79020/e93035-2013.pdf?ua=1.
Cooper LZ, Ziring PR, Ockerse AB, Fedun BA, Kiely B, Krugman S. Rubella clinical manifestations and management. Am J Dis Child. 1969;118:18–9.
Vijayalakshmi P, Kakkar G, Samprathi A, et al. Ocular manifestations of congenital rubella syndrome in a developing country. Indian J Ophthalmol. 2002;50:307–11.
Vijayalakshmi P, Rajasundari TA, Prasad NM, et al. Prevalence of eye signs in congenital rubella syndrome in South India: a role for population screening. Br J Ophthalmol. 2007;91:1467–70.
Boger WP III, Petersen RA, Robb RM. Spontaneous absorption of the lens in the congenital rubella syndrome. Arch Ophthalmol. 1981;99:433–4.
Williams LL, Lew HM, Davidorf FH, et al. Altered membrane fatty acids of cultured human retinal pigment epithelium persistently infected with rubella virus may affect secondary cellular function. Arch Virol. 1994;134:379–92.
Vijayalakshmi P, Srivastava KK, Poornima B, et al. Visual outcome of cataract surgery in children with congenital rubella syndrome. J AAPOS. 2003;7:91–5.
Shah SK, Praveen MR, Vasavada AR, Vasavada VA, Carelli R, Trivedi RH, Rasoebala V. Long-term longitudinal assessment of postoperative outcomes after congenital cataract surgery in children with congenital rubella syndrome. J Cataract Refract Surg. 2014;40:2091–8.
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Dhull, C., Khokhar, S.K. (2019). Cataract with Infective Etiology. In: Khokhar, S., Dhull, C. (eds) Atlas of Pediatric Cataract. Springer, Singapore. https://doi.org/10.1007/978-981-13-6939-1_10
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DOI: https://doi.org/10.1007/978-981-13-6939-1_10
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