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Food Processing to Eliminate Food Allergens and Development of Hypoallergenic Foods

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Food Allergy

Abstract

Food allergy is an adverse systemic immune response against food. With the continuous progress of social progress and globalization, the incidence of allergic diseases has been escalating. About 30–40% of people in the world suffer from various allergic diseases, and morbidity and mortality show rising trend year by year. Unfortunately, there are no effective methods to prevent and eradicate food allergy nowadays. So the only safe and effective way available nowadays is to avoid eating or contacting with allergens. Therefore, eliminating food allergens by food processing methods is an effective way. Although most allergens and antigenic determinants can tolerate various forms of food processing methods to a certain extent, many researches have shown that particular food processing can still affect the allergenicity. In the field of food processing, physical, chemical, enzymatic, and fermentation methods can modify the activity of allergens. Protein is one of the main components of food, and it is also an important nutrient as well as the predominant allergen category in people’s diet. Food processing methods can cause the change of spatial structure and physicochemical properties of protein macromolecules and therefore destroy the allergenic epitopes of protein. This chapter will introduce the common and advanced application of physical, chemical, and biological approaches in the elimination of allergens in food.

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References

  • Ambrosi V, Polenta G, Gonzalez C, Ferrari G, Maresca P (2016) High hydrostatic pressure assisted enzymatic hydrolysis of whey proteins. Innov Food Sci Emerg Technol 38:294–301

    Article  CAS  Google Scholar 

  • Azarkan M, Moussaoui AE, Wuytswinkel DV, Dehon G, Looze Y (2003) Fractionation and purification of the enzymes stored in the latex of Carica papaya. J Chromatogr B 790:229–238

    Article  CAS  Google Scholar 

  • Bavaro SL et al (2018) Effect of thermal/pressure processing and simulated human digestion on the immunoreactivity of extractable peanut allergens. Food Res Int 109:126–137

    Article  CAS  Google Scholar 

  • Beezhold DH, Hickey VL, Sussman GL (2001) Effects of cooking methods on peanut allergenicity. Retour Au Numéro

    Google Scholar 

  • Bohle B et al (2006) Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol 118:242

    Article  CAS  Google Scholar 

  • Brenna O, Pompei C, Ortolani C, Pravettoni V, Pastorello EA, Farioli L (2000) Technological processes to decrease the allergenicity of peach juice and nectar. J Agric Food Chem 48:493–497

    Article  CAS  Google Scholar 

  • Cabanillas B et al (2012) Influence of enzymatic hydrolysis on the allergenicity of roasted peanut protein extract. Int Arch Allergy Immunol 157:41–50

    Article  CAS  Google Scholar 

  • Chen B (2004) Study on papain decomposition of rice allergens. Food Feed Ind 9–11

    Google Scholar 

  • Cheng W, Gao J, Li X, Liu F, Chen H (2012) Preliminary study on the antigenicity of beta phenol casein crosslinked by polyphenol oxidase. Food Ind Sci Technol 219–221

    Google Scholar 

  • Chung SY, Kato Y, Champagne ET (2005) Polyphenol oxidase/caffeic acid may reduce the allergenic properties of peanut allergens. J Sci Food Agric 85:2631–2637

    Article  CAS  Google Scholar 

  • Clare DA, Gharst G, Maleki SJ, Sanders TH (2008) Effects of transglutaminase catalysis on the functional and immunoglobulin binding properties of peanut flour dispersions containing casein. J Agric Food Chem 56:10913

    Article  CAS  Google Scholar 

  • Davide G, Hong PK, Maurice N, Mirko B (2014) Conjugation of gluten hydrolysates with glucosamine at mild temperatures enhances antioxidant and antimicrobial properties. LWT Food Sci Technol 57:181–187

    Article  Google Scholar 

  • Dian M, Hangjian H, Yaqing D, Siyi P (2011) Irradiation effects on functional properties of soy protein isolate. Food Sci Technol Res 32:52–55

    Google Scholar 

  • Dong X, Gao MX, Pan J, Zhang C, Wang Z, Li S (2010) Effects of different treatments on molecular weight and antigenicity of allergic proteins of shrimp. J Nucl Agric 24:548–554

    CAS  Google Scholar 

  • Dube M, Zunker K, Neidhart S, Carle R, Steinhart H, Paschke A (2004) Effect of technological processing on the allergenicity of mangoes (Mangifera indica L.). J Agric Food Chem 52:3938

    Article  CAS  Google Scholar 

  • Farrell H Jr et al (2004) Nomenclature of the proteins of cows’ milk – sixth revision. J Dairy Sci 87:1641–1674

    Article  CAS  Google Scholar 

  • Funatsuki WM et al (2007) A specific combination of HMW and LMW glutenin subunits results in extra-strong dough properties

    Google Scholar 

  • Geng SR et al (2015) Effect of ~(60)Coγ rays irradiation dose on bovine serum albumin structure. Hubei Agric Sci

    Google Scholar 

  • Gomaa A, Boye JI (2013) Impact of thermal processing time and cookie size on the detection of casein, egg, gluten and soy allergens in food. Food Res Int 52:483–489

    Article  CAS  Google Scholar 

  • Gomaa A, Boye J (2015) Impact of irradiation and thermal processing on the immunochemical detection of milk and egg allergens in foods. Food Res Int 74:275–283

    Article  CAS  Google Scholar 

  • Han Y (2013) Effect of polyphenol oxidase cross linking on allergens of peanut allergen Ara H 2. Nanchang University, Nanchang

    Google Scholar 

  • Han J, Chen Y, Wu Y, Huang W, Ge Y (2017) The effect of ultrahigh pressure on the antigenicity and structure of the myosin of prawns by the combination of temperature and pressure. Spectrosc Spectr Anal 37:522–526

    CAS  Google Scholar 

  • Hefle SL (1999) Impact of processing on food allergens. Impact Process Food Saf 107–119

    Google Scholar 

  • Hong PK, Gottardi D, Ndagijimana M, Betti M (2014) Glycation and transglutaminase mediated glycosylation of fish gelatin peptides with glucosamine enhance bioactivity. Food Chem 142:285

    Article  CAS  Google Scholar 

  • Huang M, Zhao X, Shen J, He A (2005) Clinical application progress of chymotrypsin. Shanghai Med:462–464

    Google Scholar 

  • Jeong KY, Hong CS, Yong TS (2006) Allergenic tropomyosins and their cross-reactivities. Protein Pept Lett 13:835–845

    Article  CAS  Google Scholar 

  • Jia W et al (2014) Phase behavior of ovalbumin and carboxymethylcellulose composite system. Carbohydr Polym 109:64–70

    Article  CAS  Google Scholar 

  • Jiang S-J, Zhao XH (2010) Transglutaminase-induced cross-linking and glucosamine conjugation in soybean protein isolates and its impacts on some functional properties of the products. Eur Food Res Technol 231:679–689

    Article  CAS  Google Scholar 

  • Kasera R, Singh AB, Kumar R, Lavasa S, Prasad KN, Arora N (2012) Effect of thermal processing and γ-irradiation on allergenicity of legume proteins. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc 50:3456–3461

    Article  CAS  Google Scholar 

  • Kinsella JE (1973) Principles of enzymology for the food sciences. J Dairy Sci 56:1110–1110

    Article  Google Scholar 

  • Kinsella JE, Melachouris N (1976) Functional properties of proteins in foods: a survey. C R C Crit Rev Food Technol 7:219–280

    Article  CAS  Google Scholar 

  • Kleber N, Maier S, Hinrichs J (2007) Antigenic response of bovine β-lactoglobulin influenced by ultra-high pressure treatment and temperature. Innov Food Sci Emerg Technol 8:39–45

    Article  CAS  Google Scholar 

  • Kuan YH, Bhat R, Patras A, Karim AA (2013) Radiation processing of food proteins – a review on the recent developments. Trends Food Sci Technol 30:105–120

    Article  CAS  Google Scholar 

  • Kuang H (2013) Effect of heat treatment on food allergens and its cytological evaluation in vitro. J Food Biotechnol 907–913

    Google Scholar 

  • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685

    Article  CAS  Google Scholar 

  • Lee KA, Kim SH (2005) SSGE and DEE, new peptides isolated from a soy protein hydrolysate that inhibit platelet aggregation. Food Chem 90:389–393

    Article  CAS  Google Scholar 

  • Lee JW, Seo JH, Kim JH, Lee SY, Byun MW (2007) Comparison of the changes of the antigenicities of a hen’s egg albumin by a gamma and an electron beam irradiation. Radiat Phys Chem 76:879–885

    Article  CAS  Google Scholar 

  • Leurs R, Church MK, Taglialatela M (2002) H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 32:489–498

    Article  CAS  Google Scholar 

  • Li Z (2006) (Penaeus Vannamei) of shrimp allergen immune activity. Ocean University of China

    Google Scholar 

  • Li Z, Cao L, Lin H, Jamil K (2006) Reduction of allergenic properties of shrimp (Penaeus Vannamei) allergens by high intensity ultrasound. Eur Food Res Technol 223:639

    Article  CAS  Google Scholar 

  • Liu G (2011) Effects of processing methods on the digestive stability and anaphylaxis of crab myosin. J Chin Inst Food Sci Technol 11:14–22

    CAS  Google Scholar 

  • Liu Y, Lin H, Wu L, Chen Y, Wang G, Li Z (2011) The effect of processing methods on the immunologic of the major allergens of Penes prawns. Aquac J 35:948–953

    CAS  Google Scholar 

  • Long F, Yang X, Wang R, Hu X, Chen F (2015) Effects of combined high pressure and thermal treatments on the allergenic potential of shrimp (Litopenaeus vannamei) tropomyosin in a mouse model of allergy. Innov Food Sci Emerg Technol 29:119–124

    Article  CAS  Google Scholar 

  • Luo C, Hu C, Gao J, Li X, Wu Z, Yang A, Chen H (2013) A potential practical approach to reduce Ara h 6 allergenicity by gamma irradiation. Food Chem 136:1141–1147

    Article  CAS  Google Scholar 

  • Martos G, Lopez-Exposito I, Bencharitiwong R, Berin MC, Nowak-Węgrzyn A (2011) Mechanisms underlying differential food allergy response to heated egg. J Allergy Clin Immunol 127:990–997

    Article  CAS  Google Scholar 

  • Matsuzaki T, Farnworth ER (2008) Health properties of milk fermented with Lactobacillus casei strain Shirota (LcS)

    Google Scholar 

  • Meinlschmidt P, Ueberham E, Lehmann J, Reineke K, Schlüter O, Schweiggert-Weisz U, Eisner P (2016) The effects of pulsed ultraviolet light, cold atmospheric pressure plasma, and gamma-irradiation on the immunoreactivity of soy protein isolate. Innov Food Sci Emerg Technol 38:374–383

    Article  CAS  Google Scholar 

  • Mills EN, Marigheto NA, Wellner N, Fairhurst SA, Jenkins JA, Mann R, Belton PS (2003) Thermally induced structural changes in glycinin, the 11S globulin of soya bean (Glycine max) – an in situ spectroscopic study. Biochim Biophys Acta 1648:105–114

    Article  CAS  Google Scholar 

  • Mills EN, Sancho AI, Rigby NM, Jenkins JA, Mackie AR (2009) Impact of food processing on the structural and allergenic properties of food allergens. Mol Nutr Food Res 53:963–969

    Article  CAS  Google Scholar 

  • Molins RA (2001) Food irradiation: principles and applications. Food Irradiat Princ Appl 18:219

    Google Scholar 

  • Naqpal S, Rajappa L, Metcalfe DD, Rao PV (1989) Isolation and characterization of heat-stable allergens from shrimp (Penaeus indicus). J Allergy Clin Immunol 83:26–36

    Article  CAS  Google Scholar 

  • Nooji JK (2011) Reduction of wheat allergen potency by pulsed ultraviolet light, high hydrostatic pressure, and non-thermal plasma

    Google Scholar 

  • Norgaard A, Skov PS, Bindslev-Jensen C (1992) Egg and milk allergy in adults: comparison between fresh foods and commercial allergen extracts in skin prick test and histamine release from basophils. Clin Exp Allergy 22:940–947

    Article  CAS  Google Scholar 

  • North MJ, Mottram JC, Coombs GH (1990) Cysteine proteinases of parasitic protozoa. Parasitol Today 6:270–275

    Article  CAS  Google Scholar 

  • Radosavljevic J et al (2014) Sensitizing potential of enzymatically cross-linked peanut proteins in a mouse model of peanut allergy. Mol Nutr Food Res 58:635–646

    Article  CAS  Google Scholar 

  • Ren Z, Zhou C (2014) Effects of transglutaminase crosslinking on the functional characteristics of enzymatic hydrolysis protein from Tilapia waste [J]. Food Sci Technol 6:252–256

    Google Scholar 

  • Ruan W (2012) Effects of modification on the properties of allergen of Scylla acerba. JiMei University

    Google Scholar 

  • Sampson SSH (2014) Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 133:291–307

    Article  Google Scholar 

  • Sancho AI et al (2005) The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. Allergy 60:1262–1268

    Article  CAS  Google Scholar 

  • Shen X, Zheng H, Luo Y, Qiao C (2006) The effect of enzymatic hydrolysis on whey protein antigenicity. China Dairy Ind 12–15

    Google Scholar 

  • Shi Y, Li RY, Tu ZC, Ma D, Wang H, Huang XQ, He N (2015) Effect of γ-irradiation on the physicochemical properties and structure of fish myofibrillar proteins. Radiat Phys Chem 109:70–72

    Article  CAS  Google Scholar 

  • Skanderby M (1994) Protein hydrolysates: their functionality and applications. Food Technol Eur 10:141–148

    Google Scholar 

  • Vaz AFM, Costa RMPB, Coelho LCBB, Oliva MLV, Santana LA, Melo AMMA, Correia MTS (2011) Gamma irradiation as an alternative treatment to abolish allergenicity of lectins in food. Food Chem 124:1289–1295

    Article  CAS  Google Scholar 

  • Vissers YM et al (2011) Effect of heating and glycation on the allergenicity of 2S albumins (Ara h 2/6) from peanut. PLoS One 6:e23998

    Article  CAS  Google Scholar 

  • Wang Y, Zhang L (2008) Research progress in pepsin purification technology. Chin Food Addit 110–113

    Google Scholar 

  • Wang S, Zhang C, Li S (2009) Radiation treatment on peanut allergen protein. Acta Groundnut 38:1–5

    Google Scholar 

  • Wang J, Zhou Y, Lin D (2014) Fermentation effects on sensitizing factors in peanut protein. J Henan Univ Technol (Nat Sci) 35

    Google Scholar 

  • Wihodo M, Moraru CI (2013) Physical and chemical methods used to enhance the structure and mechanical properties of protein films: a review. J Food Eng 114:292–302

    Article  CAS  Google Scholar 

  • Xia Y (2012) Basic research on ultra high pressure food processing technology. Dalian University of Technology

    Google Scholar 

  • Xin L, Hongbing C (2005) Changes of allergen in food processing. Food Ind 50–52

    Google Scholar 

  • Xu X, Gao X, Xu D, Liao C (2006) Potency determination of chymotrypsin. J Chengdu Med Coll 123–124

    Google Scholar 

  • Yan SB, Wold F (1984) Neoglycoproteins: in vitro introduction of glycosyl units at glutamines in beta-casein using transglutaminase. Biochemistry 23:3759–3765

    Article  CAS  Google Scholar 

  • Yuan F, Lv L, Li Z, Mi N, Chen H, Lin H (2016) Effect of transglutaminase-catalyzed glycosylation on the allergenicity and conformational structure of shrimp (Metapenaeus ensis) tropomyosin. Food Chem 219:215

    Article  Google Scholar 

  • Zayas JF (1997) Solubility of proteins. Funct Proteins Food 6–75

    Google Scholar 

  • Zhang L (2013) Effects of electron beam irradiation on the activity and texture of fish allergens. Ocean University of China

    Google Scholar 

  • Zhang C (2015) Effect of enzymatic hydrolysis on allergenic protein of shrimp shrimps. China Jiliang University

    Google Scholar 

  • Zhang L, Yuan Y, Xu M (2009) Preparation of immobilized trypsin research. Food Ferment Technol 45:18–21

    Google Scholar 

  • Zhang J, Meng Y, Yang J, Zhang Z (2011) Study on the technological process of hydrolyzed whey protein. Dairy Sci Technol 34:55–57

    Google Scholar 

  • Zhao YJ, Cai QF, Jin TC, Zhang LJ, Fei DX, Liu GM, Cao MJ (2017) Effect of Maillard reaction on the structural and immunological properties of recombinant silver carp parvalbumin. LWT Food Sci Technol 75:25–33

    Article  CAS  Google Scholar 

  • Zheng H, Shen X, Hao B, Luo Y (2007) Optimization of alkaline protease hydrolysis of whey protein allergen conditions. China Dairy Ind 35:4–9

    Google Scholar 

  • Zhong J, Liu C, Liu W, Cai X, Tu Z, Wan J (2011) Effect of dynamic high-pressure microfluidization at different temperatures on the antigenic response of bovine β-lactoglobulin. Eur Food Res Technol 233:95–102

    Article  CAS  Google Scholar 

  • Zhou L, Liu X, Liu Y, Zheng X (2014) TGase catalyzed glycosylation of zein. Food Sci Technol Res 15–19

    Google Scholar 

  • Zhu XW, Huang H, Zhao Q, Qiu T, Pan S (2012) Research progress in modification of soy protein at subunit level. Food Sci Technol Res 388–392

    Google Scholar 

  • Zong-Cai TU, Xie H, Niu PP, Wang H, Da MA (2016) Effect of ~(60)Co radiation on structure and antioxidant activity of ovalbumin. Sci Technol Food Ind

    Google Scholar 

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Authors and Affiliations

  1. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hanghzou, China

    Linglin Fu & Yanbo Wang

  2. Mucosal Immunology and Biology Research, Harvard Medical School, Charlestown, MA, USA

    Bobby J. Cherayil & Haining Shi

  3. Bioprocess Engineering Group, Agrotechnology and Food Sciences, Wageningen University and Research, Wageningen, The Netherlands

    Yang Zhu

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  1. Linglin Fu
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  2. Bobby J. Cherayil
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  3. Haining Shi
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  4. Yanbo Wang
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  5. Yang Zhu
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Fu, L., Cherayil, B.J., Shi, H., Wang, Y., Zhu, Y. (2019). Food Processing to Eliminate Food Allergens and Development of Hypoallergenic Foods. In: Food Allergy. Springer, Singapore. https://doi.org/10.1007/978-981-13-6928-5_6

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