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Introduction: Sequence-Specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications

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Synthesis and Biological Evaluation of Pyrrole–Imidazole Polyamide Probes for Visualization of Telomeres

Part of the book series: Springer Theses ((Springer Theses))

Abstract

Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds that bind to the minor groove of double-stranded DNA in a sequence-specific manner without causing denaturation of the DNA. These compounds can be used to control gene expression and to stain specific sequences in cells. Here, we review the history, structural variations, and functional investigations of Py–Im polyamides.

This chapter is reprinted and modified with permission from “Sequence-specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications” Kawamoto, Y.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem. 2018, 26, 1393–1411. Copyright 2018 Elsevier.

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    Yusuke Kawamoto

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Kawamoto, Y. (2019). Introduction: Sequence-Specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications. In: Synthesis and Biological Evaluation of Pyrrole–Imidazole Polyamide Probes for Visualization of Telomeres. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-13-6912-4_1

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