Abstract
Fabrication of soft actuators that may perform multiple tasks simultaneously, as observed for the complex natural systems, is one of the goals in biomimetics. Biomolecular motor systems are the smallest natural machine that can perform mechanical work with a high efficiency. Because of their wide range of scalability and adaptability, the biomolecular motor systems are promising candidates for developing biomimetic soft actuators. The biological power units are able to convert chemical energy obtained from hydrolysis of adenosine triphosphate (ATP) into mechanical work. By virtue of their highly efficient mechanism of power generation, they are able to form highly ordered structures in living organism, which facilitates their emergent functions. To exploit the advantages of the biomolecular motor systems, nowadays they are used as building blocks of biomimetic soft actuators or devices. In this chapter we discuss the latest applications of a classical biomolecular motor system microtubule/kinesin in designing biomimetic soft actuators and micro devices. Nowadays the microtubule/kinesin system can be reconstructed and self-assembled or integrated to complex hierarchical structures which offer emergent functions. Utilization of biomolecular motor systems can greatly advance the development of highly efficient biomimetic soft actuators which in turn would benefit soft robotics in near future.
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References
Miriyev A, Stack K, Lipson H (2017) Soft material for soft actuators. Nat Commun 8:596
Rus D, Tolley MT (2015) Design, fabrication and control of soft robots. Nature 521:467–475
Trimmer B (2013) Soft robots. Curr Biol 23:R639–R641
Kim S, Laschi C, Trimmer B (2013) Soft robotics: a bioinspired evolution in robotics. Trends Biotechnol 31:287–294
Osada Y, Okuzaki H, Hori H (1992) A polymer gel with electrically driven motility. Nature 355:242–244
Osada Y, Gong JP (1998) Soft and wet materials: polymer gels. Adv Mater 10:827–837
Bar-Cohen Y (ed) (2001) Electroactive polymer (EAP) actuators as artificial muscles, reality, potential and challenges. SPIE, Bellingham
Spinks GM, Mottaghitalab V, Bahrami-Samani M, Whitten PG, Wallace GG (2006) Carbon-nanotube-reinforced polyaniline fibers for high-strength artificial muscles. Adv Mater 18:637–640
Howard J (2001) Mechanics of motor proteins and the cytoskeleton. Sinauer, Sunderland
Harold FM (2001) The way of the cell. Oxford University Press, Oxford
Bachand GD, Bouxsein NF, VanDelinder V, Bachand M (2014) Biomolecular motors in nanoscale materials, devices, and systems. WIREs Nanomed Nanobiotechnol 6:163–177
Kakugo A, Sugimoto S, Gong JP, Osada Y (2002) Gel machines constructed from chemically cross-linked actin and myosins. Adv Mater 14:1124–1126
Hess H, Bachand GD (2005) Biomolecular motors. Mater Today 8:22–29
Rubenstein M, Cornejo A, Nagpal R (2014) Programmable self-assembly in a thousand robot swarm. Science 345:795–799
Schaller V, Weber C, Semmrich C, Frey E, Bausch AR (2010) Polar patterns of driven filaments. Nature 467:73–77
Sumino Y, Nagai KH, Shitaka Y, Tanaka D, Yoshikawa K, Chaté H, Oiwa K (2012) Large-scale vortex lattice emerging from collectively moving microtubules. Nature 483:448–452
Hess H, Ross JL (2017) Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots. Chem Soc Rev 46:5570–5587
Nogales E, Wolf SG, Downing KH (1998) Structure of the alpha beta tubulin dimer by electron crystallography. Nature 391:199–203
Drabik P, Gusarov S, Kovalenko A (2007) Microtubule stability studied by three-dimensional molecular theory of solvation. Biophys J 92:394–403
Chrétien D, Metoz F, Verde F, Karsenti E, Wade RH (1992) Lattice defects in microtubules: protofilament numbers vary within individual microtubules. J Cell Biol 117:1031–1040
Hirokawa N, Takemura R (2004) Kinesin superfamily proteins and their various functions and dynamics. Exp Cell Res 301:50–59
Sharp DJ, Rogers GC, Scholey JM (2000) Microtubule motors in mitosis. Nature 407:41–47
Howard J, Hudspeth AJ, Vale RD (1989) Movement of microtubules by single kinesin molecules. Nature 342:154–158
Hunt AJ, Gittes F, Howard J (1994) The force exerted by a single kinesin molecule against a viscous load. Biophys J 67:766–781
Visscher K, Schnitzer MJ, Block SM (1999) Single kinesin molecules studied with a molecular force clamp. Nature 400:184–189
Schnapp BJ, Vale RD, Sheetz MP, Reese TS (1985) Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell 40:455–462
Grzybowski BA, Wiles JA, Whitesides GM (2003) Dynamic self-assembly of rings of charged metallic spheres. Phys Rev Lett 90:083903
Hess H, Clemmens J, Brunner C, Doot R, Luna S, Karl-Heinz E, Vogel V (2005) Molecular self-assembly of “nanowires and nanospools” using active transport. Nano Lett 5:629–633
Tamura Y, Kawamura R, Shikinaka K, Kakugo A, Osada Y, Gong JP, Mayama H (2011) Dynamic self-organization and polymorphism of microtubule assembly through active interactions with kinesin. Soft Matter 7:5654–5659
Idan O, Lam A, Kamcev J, Gonzales J, Agarwal A, Hess H (2012) Nanoscale transport enables active self-assembly of millimeter-scale wires. Nano Lett 12:240–245
Hess H (2006) Self-assembly driven by molecular motors. Soft Matter 2:669–677
Wada S, Kabir AMR, Ito M, Inoue D, Sada K, Kakugo A (2015) Effect of length and rigidity of microtubules on the size of ring-shaped assemblies obtained through active self-organization. Soft Matter 11:1151–1157
Jeune-Smith Y, Hess H (2010) Engineering the length distribution of microtubules polymerized in vitro. Soft Matter 6:1778–1784
Inoue D, Kabir AMR, Mayama H, Gong JP, Sada K, Kakugo A (2013) Growth of ring-shaped microtubule assemblies through stepwise active self-organization. Soft Matter 9:7061–7068
Ray S, Meyhöfer E, Milligan RA, Howard J (1993) Kinesin follows the microtubule’s protofilament axis. J Cell Biol 121:1083–1093
Kawamura R, Kakugo A, Shikinaka K, Osada Y, Gong JP (2008) Ring-shaped assembly of microtubules shows preferential counterclockwise motion. Biomacromolecules 9:2277–2282
Kakugo A, Kabir AMR, Hosoda N, Shikinaka K, Gong JP (2011) Controlled clockwise-counterclockwise motion of the ring-shaped microtubules assembly. Biomacromolecules 12:3394–3399
Wada S, Kabir AMR, Kawamura R, Ito M, Inoue D, Sada K, Kakugo A (2015) Controlling the bias of rotational motion of ring-shaped microtubule assembly. Biomacromolecules 16:374–378
Vicsek T, Zafeiris A (2012) Collective motion. Phys Rep 517:71–140
Inoue D, Mahmot B, Kabir AMR, Farhana TI, Tokuraku K, Sada K, Konagaya A, Kakugo A (2015) Depletion force induced collective motion of microtubules driven by kinesin. Nanoscale 7:18054–18061
Köhler S, Lieleg O, Bausch AR (2008) Rheological characterization of the bundling transition in F-actin solutions induced by methylcellulose. PLoS One 3:e2736
Saito A, Farhana TI, Kabir AMR, Inoue D, Konagaya A, Sada K, Kakugo A (2017) Understanding the emergence of collective motion of microtubules driven by kinesins: role of concentration of microtubules and depletion force. RSC Adv 7:13191–13197
Yashin VV, Balazs AC (2006) Pattern formation and shape changes in self-oscillating polymer gels. Science 314:798–801
Kabir AMR, Wada S, Inoue D, Tamura Y, Kajihara T, Mayama H, Sada K, Kakugo A, Gong JP (2012) Formation of ring-shaped assembly of microtubules with a narrow size distribution at an air-buffer interface. Soft Matter 8:10863–10867
Ito M, Kabir AMR, Islam MS, Inoue D, Wada S, Sada K, Konagaya A, Kakugo A (2016) Mechanical oscillation of dynamic microtubule rings. RSC Adv 6:69149–69155
Hess H (2011) Engineering applications of biomolecular motors. Annu Rev Biomed Eng 13:429–450
Sanchez T, Welch D, Nicastro D, Dogic Z (2011) Cilia-like beating of active microtubule bundles. Science 333:456–459
Sasaki R, Kabir AMR, Inoue D, Anan S, Kimura AP, Konagaya A, Sada K, Kakugo A (2018) Construction of artificial cilia from microtubules and kinesins through a well-designed bottom-up approach. Nanoscale 10:6323–6332
Cadart C, Zlotek-Zlotkiewicz E, Berre ML, Piel M, Matthews HK (2014) Exploring the function of cell shape and size during mitosis. Dev Cell 29:159–169
Islam MS, Kuribayashi-Shigetomi K, Kabir AMR, Inoue D, Sada K, Kakugo A (2017) Role of confinement in the active self-organization of kinesin-driven microtubules. Sensors Actuators B Chem 247:53–60
Sato Y, Hiratsuka Y, Kawamata I, Murata S, Nomura SM (2017) Micrometer-sized molecular robot changes its shape in response to signal molecules. Sci Robotics 2:eaal3735
Tsuji M, Kabir AMR, Ito M, Inoue D, Kokado K, Sada K, Kakugo A (2017) Motility of microtubules on the inner surface of water-in-oil emulsion droplets. Langmuir 33:12108–12113
Goel A, Vogel V (2008) Harnessing biological motors to engineer systems for nanoscale transport and assembly. Nat Nanotechnol 3:465–475
Hagiya M, Konagaya A, Kobayashi S, Saito H, Murata S (2014) Molecular robots with sensors and intelligence. Acc Chem Res 47:1681–1690
Hess H, Clemmens J, Howard J, Vogel V (2002) Surface imaging by self-propelled nanoscale probes. Nano Lett 2:113–116
Hess H, Howard J, Vogel V (2002) A piconewton forcemeter assembled from microtubules and kinesins. Nano Lett 2:1113–1115
Inoue D, Nitta T, Kabir AMR, Sada K, Gong JP, Konagaya A, Kakugo A (2016) Sensing surface mechanical deformation using active probes driven by motor proteins. Nat Commun 7:12557
Kabir AMR, Inoue D, Kakugo A, Kamei A, Gong JP (2011) Prolongation of the active lifetime of a biomolecular motor for in vitro motility assay by using an inert atmosphere. Langmuir 27:13659–13668
Bonabeau E, Dorigo M, Theraulaz G (1999) Swarm intelligence: from natural to artificial systems. Oxford University Press, Oxford/New York
Keya JJ, Suzuki R, Kabir AMR, Inoue D, Asanuma H, Sada K, Hess H, Kuzuya A, Kakugo A (2018) DNA-assisted swarm control in a biomolecular motor system. Nat Commun 9:453
Qian L, Winfree E (2011) Scaling up digital circuit computation with DNA strand displacement cascade. Science 332:1196–1201
Wollman AJM, Sanchez-Cano C, Carstairs HMJ, Cross RA, Turberfield AJ (2014) Transport and self-organization across different length scales powered by motor proteins and programmed by DNA. Nat Nanotechnol 9:44–47
Hiyama S, Moritani Y, Gojo R, Takeuchi S, Sutoh K (2010) Biomolecular-motor-based autonomous delivery of lipid vesicles as nano- or microscale reactors on a chip. Lab Chip 10:2741–2748
Früh SM, Steuerwald D, Simon U, Vogel V (2012) Covalent cargo loading to molecular shuttles via copper-free “click chemistry”. Biomacromolecules 13:3908–3911
Keya JJ, Kabir AMR, Inoue D, Sada K, Hess H, Kuzuya A, Kakugo A (2018) Control of swarming of molecular robots. Sci Rep 8:11756
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Keya, J.J., Kayano, K., Kabir, A.M.R., Kakugo, A. (2019). Integration of Soft Actuators Based on a Biomolecular Motor System to Develop Artificial Machines. In: Asaka, K., Okuzaki, H. (eds) Soft Actuators. Springer, Singapore. https://doi.org/10.1007/978-981-13-6850-9_39
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DOI: https://doi.org/10.1007/978-981-13-6850-9_39
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